J 2020

Role of Sodium/Calcium Exchangers in Tumors

CHOVANCOVA, Barbora, Veronika LISKOVA, Petr BABULA and Olga KRIŽANOVÁ

Basic information

Original name

Role of Sodium/Calcium Exchangers in Tumors

Authors

CHOVANCOVA, Barbora (703 Slovakia), Veronika LISKOVA (703 Slovakia), Petr BABULA (203 Czech Republic, belonging to the institution) and Olga KRIŽANOVÁ (703 Slovakia, guarantor, belonging to the institution)

Edition

Biomolecules, BASEL, MDPI, 2020, 2218-273X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.879

RIV identification code

RIV/00216224:14110/20:00116820

Organization unit

Faculty of Medicine

DOI

UT WoS

000579996000001

Keywords in English

sodium-calcium exchanger; cancer cells; calcium; apoptosis

Tags

Tags

International impact, Reviewed
Změněno: 10/11/2021 08:30, Mgr. Tereza Miškechová

Abstract

V originále

The sodium/calcium exchanger (NCX) is a unique calcium transport system, generally transporting calcium ions out of the cell in exchange for sodium ions. Nevertheless, under special conditions this transporter can also work in a reverse mode, in which direction of the ion transport is inverted-calcium ions are transported inside the cell and sodium ions are transported out of the cell. To date, three isoforms of the NCX have been identified and characterized in humans. Majority of information about the NCX function comes from isoform 1 (NCX1). Although knowledge about NCX function has evolved rapidly in recent years, little is known about these transport systems in cancer cells. This review aims to summarize current knowledge about NCX functions in individual types of cancer cells.