Interacting effects of the MAM model of schizophrenia and
antipsychotic treatment: Untargeted proteomics approach in
adipose tissue

J 2021

Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue

KUČERA, Jan, Kateřina HORSKÁ, Pavel HRUŠKA, Daniela KURUCZOVÁ, Vincenzo MICALE et. al.

Basic information

Original name

Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue

Name in Czech

Interakce vlivu MAM modelu schizofrenie a podání antipsychotik: netargetovaná proteomická analýza

Authors

KUČERA, Jan (203 Czech Republic, belonging to the institution), Kateřina HORSKÁ (203 Czech Republic, belonging to the institution), Pavel HRUŠKA (203 Czech Republic, belonging to the institution), Daniela KURUCZOVÁ (703 Slovakia, belonging to the institution), Vincenzo MICALE (380 Italy), Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution) and Julie DOBROVOLNÁ (203 Czech Republic, belonging to the institution)

Edition

Progress in Neuro-Psychopharmacology & Biological Psychiatry, Oxford, PERGAMON-ELSEVIER SCIENCE LTD, 2021, 0278-5846

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.201

RIV identification code

RIV/00216224:14160/21:00120788

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1016/j.pnpbp.2020.110165

UT WoS

000643709100011

Keywords in English

Antipsychotics; Adipose tissue; Schizophrenia; Animal model; Proteomics; Methylazoxymethanol

Abstract

V originále

Highlights Proteomics show deregulated mTOR in adipose tissue of schizophrenia-like rat model. Antipsychotics alter adipose proteome in schizophrenia-like rats but not in controls. Different antipsychotics have a distinct impact on the adipose tissue proteome. Antipsychotics modify metabolic and energetic pathways in adipose tissue.

Links

MUNI/A/1292/2019, interní kód MU

Name: Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masaryk University, Category A

MUNI/A/1698/2020, interní kód MU

Name: Od molekulární, buněčné a tkáňové k systémové patofyziologii vybraných komplexních nemocí (Acronym: ComplexPF)

Investor: Masaryk University

Citovat

KUČERA, Jan, Kateřina HORSKÁ, Pavel HRUŠKA, Daniela KURUCZOVÁ, Vincenzo MICALE, Jana RUDÁ and Julie DOBROVOLNÁ. Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue. Progress in Neuro-Psychopharmacology & Biological Psychiatry. Oxford: PERGAMON-ELSEVIER SCIENCE LTD, 2021, vol. 2021, No 108, p. 1-15. ISSN 0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2020.110165.

@article{1691016,
   author = {Kučera, Jan and Horská, Kateřina and Hruška, Pavel and Kuruczová, Daniela and Micale, Vincenzo and Rudá, Jana and Dobrovolná, Julie},
   article_location = {Oxford},
   article_number = {108},
   doi = {http://dx.doi.org/10.1016/j.pnpbp.2020.110165},
   keywords = {Antipsychotics; Adipose tissue; Schizophrenia; Animal model; Proteomics; Methylazoxymethanol},
   language = {eng},
   issn = {0278-5846},
   journal = {Progress in Neuro-Psychopharmacology & Biological Psychiatry},
   title = {Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue},
   url = {https://www.sciencedirect.com/science/article/pii/S0278584620304814?via%3Dihub},
   volume = {2021},
   year = {2021}
}

TY  - JOUR
ID  - 1691016
AU  - Kučera, Jan - Horská, Kateřina - Hruška, Pavel - Kuruczová, Daniela - Micale, Vincenzo - Rudá, Jana - Dobrovolná, Julie
PY  - 2021
TI  - Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue
JF  - Progress in Neuro-Psychopharmacology & Biological Psychiatry
VL  - 2021
IS  - 108
SP  - 1-15
EP  - 1-15
PB  - PERGAMON-ELSEVIER SCIENCE LTD
SN  - 02785846
KW  - Antipsychotics
KW  - Adipose tissue
KW  - Schizophrenia
KW  - Animal model
KW  - Proteomics
KW  - Methylazoxymethanol
UR  - https://www.sciencedirect.com/science/article/pii/S0278584620304814?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S0278584620304814?via%3Dihub
N2  - Highlights Proteomics show deregulated mTOR in adipose tissue of schizophrenia-like rat model. Antipsychotics alter adipose proteome in schizophrenia-like rats but not in controls. Different antipsychotics have a distinct impact on the adipose tissue proteome. Antipsychotics modify metabolic and energetic pathways in adipose tissue.
ER  -

KUČERA, Jan, Kateřina HORSKÁ, Pavel HRUŠKA, Daniela KURUCZOVÁ, Vincenzo MICALE, Jana RUDÁ and Julie DOBROVOLNÁ. Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue. \textit{Progress in Neuro-Psychopharmacology \&{} Biological Psychiatry}. Oxford: PERGAMON-ELSEVIER SCIENCE LTD, 2021, vol.~2021, No~108, p.~1-15. ISSN~0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2020.110165.

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