Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue

KUČERA, Jan, Kateřina HORSKÁ, Pavel HRUŠKA, Daniela KURUCZOVÁ, Vincenzo MICALE, Jana RUDÁ and Julie DOBROVOLNÁ. Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue. Progress in Neuro-Psychopharmacology & Biological Psychiatry. Oxford: PERGAMON-ELSEVIER SCIENCE LTD, 2021, vol. 2021, No 108, p. 1-15. ISSN 0278-5846. Available from: https://dx.doi.org/10.1016/j.pnpbp.2020.110165.

Basic information

• Original name: Interacting effects of the MAM model of schizophrenia and antipsychotic treatment: Untargeted proteomics approach in adipose tissue
• Name in Czech: Interakce vlivu MAM modelu schizofrenie a podání antipsychotik: netargetovaná proteomická analýza
• Authors: KUČERA, Jan (203 Czech Republic, belonging to the institution), Kateřina HORSKÁ (203 Czech Republic, belonging to the institution), Pavel HRUŠKA (203 Czech Republic, belonging to the institution), Daniela KURUCZOVÁ (703 Slovakia, belonging to the institution), Vincenzo MICALE (380 Italy), Jana RUDÁ (203 Czech Republic, guarantor, belonging to the institution) and Julie DOBROVOLNÁ (203 Czech Republic, belonging to the institution).
• Edition: Progress in Neuro-Psychopharmacology & Biological Psychiatry, Oxford, PERGAMON-ELSEVIER SCIENCE LTD, 2021, 0278-5846.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 5.201
• RIV identification code: RIV/00216224:14160/21:00120788
• Organization unit: Faculty of Pharmacy
• Doi: http://dx.doi.org/10.1016/j.pnpbp.2020.110165
• UT WoS: 000643709100011
• Keywords in English: Antipsychotics; Adipose tissue; Schizophrenia; Animal model; Proteomics; Methylazoxymethanol
• Tags: 14110516, 14110518, podil, rivok, ÚFTo
• Tags: International impact, Reviewed

Abstract

Highlights Proteomics show deregulated mTOR in adipose tissue of schizophrenia-like rat model. Antipsychotics alter adipose proteome in schizophrenia-like rats but not in controls. Different antipsychotics have a distinct impact on the adipose tissue proteome. Antipsychotics modify metabolic and energetic pathways in adipose tissue.

Links

• MUNI/A/1292/2019, interní kód MU: Name: Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masaryk University, Category A

• MUNI/A/1698/2020, interní kód MU: Name: Od molekulární, buněčné a tkáňové k systémové patofyziologii vybraných komplexních nemocí (Acronym: ComplexPF)

Investor: Masaryk University