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@article{1692085,
author = {Stránská, Kamila and Plevová, Karla and Skuhrová Francová, Hana and Škabrahová, Hana and von JagwitzandBiegnitz, Magdalena and Radová, Lenka and Panovská, Anna and Hrobková, Stanislava and Brychtová, Yvona and Urbanová, Renata and Smolej, Lukáš and Simkovic, Martin and Zuchnická, Jana and Mohammadova, Lekaa and Špaček, Martin and Mayer, Jiří and Pospíšilová, Šárka and Doubek, Michael},
article_location = {Olomouc},
article_number = {4},
doi = {http://dx.doi.org/10.5507/bp.2019.046},
keywords = {CLL; B-cell receptor; clonality; questionnaire; patient history; biological risk factor},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers : Univerzita Palackého v Olomouci},
title = {Profiling of biological and environmental risk factors in immunogenetic subgroups of chronic lymphocytic leukemia},
url = {https://biomed.papers.upol.cz/pdfs/bio/2020/04/11.pdf},
volume = {164},
year = {2020}
}
TY - JOUR
ID - 1692085
AU - Stránská, Kamila - Plevová, Karla - Skuhrová Francová, Hana - Škabrahová, Hana - von Jagwitz-Biegnitz, Magdalena - Radová, Lenka - Panovská, Anna - Hrobková, Stanislava - Brychtová, Yvona - Urbanová, Renata - Smolej, Lukáš - Simkovic, Martin - Zuchnická, Jana - Mohammadova, Lekaa - Špaček, Martin - Mayer, Jiří - Pospíšilová, Šárka - Doubek, Michael
PY - 2020
TI - Profiling of biological and environmental risk factors in immunogenetic subgroups of chronic lymphocytic leukemia
JF - Biomedical Papers : Univerzita Palackého v Olomouci
VL - 164
IS - 4
SP - 425-434
EP - 425-434
PB - PALACKY UNIV, MEDICAL FAC, CENTRAL LIBRARY
SN - 12138118
KW - CLL
KW - B-cell receptor
KW - clonality
KW - questionnaire
KW - patient history
KW - biological risk factor
UR - https://biomed.papers.upol.cz/pdfs/bio/2020/04/11.pdf
L2 - https://biomed.papers.upol.cz/pdfs/bio/2020/04/11.pdf
N2 - Aims. This is a nation-wide survey of chronic lymphocytic leukemia (CLL) patients at six large hematology centers in the Czech Republic. The aim was to identify specific populations, social, and health characteristics of CLL subgroups divided according to the immunogenetic features of their B cell receptors (BCRs) and clonality. Patients and Methods. Questionnaires directed to specific health, social, and environmental conditions were collected in a cohort of 573 CLL patients. For these patients, immunoglobulin heavy chain gene rearrangements were also analyzed in order to gain information about their clonality, IGHV mutational status, and the presence of stereotyped BCRs. Data extracted from the questionnaires were analyzed statistically in the context of immunogenetic features of the cohort. Results. There were no statistically significant differences in the data collected in the survey between patients with mutated and patients with unmutated IGHV. However, patients with oligoclonal CLL reported health conditions such as hypercholesterolemia, hypertension, herpes simplex, tumors, and also, separately, CLL in 1st degree relatives, more often than their monoclonal counterparts. In patients with stereotyped BCRs, we found more frequent alcohol consumption and gastric infections in subset #1 cases and frequent cholecystectomies and familial CLL in subset #2 cases. Conclusion. To the best of our knowledge, this study is the first to investigate CLL immunogenetic features and clonality in the context of epidemiological data. We reported statistically significant associations suggesting the influence of certain health and social conditions on a number of clonal populations expanding in CLL and also on characteristic BCR features, especially stereotypy.
ER -
STRÁNSKÁ, Kamila, Karla PLEVOVÁ, Hana SKUHROVÁ FRANCOVÁ, Hana ŠKABRAHOVÁ, Magdalena VON JAGWITZ-BIEGNITZ, Lenka RADOVÁ, Anna PANOVSKÁ, Stanislava HROBKOVÁ, Yvona BRYCHTOVÁ, Renata URBANOVÁ, Lukáš SMOLEJ, Martin SIMKOVIC, Jana ZUCHNICKÁ, Lekaa MOHAMMADOVA, Martin ŠPAČEK, Jiří MAYER, Šárka POSPÍŠILOVÁ and Michael DOUBEK. Profiling of biological and environmental risk factors in immunogenetic subgroups of chronic lymphocytic leukemia. \textit{Biomedical Papers : Univerzita Palackého v Olomouci}. Olomouc: PALACKY UNIV, MEDICAL FAC, CENTRAL LIBRARY, 2020, vol.~164, No~4, p.~425-434. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2019.046.
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