MARTÍN MOYANO, Paula, Václav NĚMEC a Kamil PARUCH. Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential. International Journal of Molecular Sciences. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč. 21, č. 20, s. 1-31. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21207549. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1695616, author = {Martín Moyano, Paula and Němec, Václav and Paruch, Kamil}, article_location = {Basel}, article_number = {20}, doi = {http://dx.doi.org/10.3390/ijms21207549}, keywords = {CLK; cdc-like kinase; inhibitor; chemical biology; tool compound; chemical probe; T3; SGC-CLK-1; MU1210; SM08502}, language = {eng}, issn = {1422-0067}, journal = {International Journal of Molecular Sciences}, title = {Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential}, url = {https://doi.org/10.3390/ijms21207549}, volume = {21}, year = {2020} }
TY - JOUR ID - 1695616 AU - Martín Moyano, Paula - Němec, Václav - Paruch, Kamil PY - 2020 TI - Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential JF - International Journal of Molecular Sciences VL - 21 IS - 20 SP - 1-31 EP - 1-31 PB - Multidisciplinary Digital Publishing Institute SN - 14220067 KW - CLK KW - cdc-like kinase KW - inhibitor KW - chemical biology KW - tool compound KW - chemical probe KW - T3 KW - SGC-CLK-1 KW - MU1210 KW - SM08502 UR - https://doi.org/10.3390/ijms21207549 L2 - https://doi.org/10.3390/ijms21207549 N2 - Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds' potential to be utilized as quality chemical biology probes. ER -
MARTÍN MOYANO, Paula, Václav NĚMEC a Kamil PARUCH. Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential. \textit{International Journal of Molecular Sciences}. Basel: Multidisciplinary Digital Publishing Institute, 2020, roč.~21, č.~20, s.~1-31. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms21207549.
|