Failure properties of abdominal aortic aneurysm tissue are
orientation dependent

J 2021

Failure properties of abdominal aortic aneurysm tissue are orientation dependent

POLZER, Stanislav, Vojtěch MAN, Robert VLACHOVSKÝ, Luboš KUBÍČEK, Jan KRACÍK et. al.

Basic information

Original name

Failure properties of abdominal aortic aneurysm tissue are orientation dependent

Authors

POLZER, Stanislav (203 Czech Republic, guarantor), Vojtěch MAN (203 Czech Republic), Robert VLACHOVSKÝ (203 Czech Republic, belonging to the institution), Luboš KUBÍČEK (203 Czech Republic, belonging to the institution), Jan KRACÍK (203 Czech Republic), Robert STAFFA (203 Czech Republic, belonging to the institution), Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Jiří BURŠA (203 Czech Republic) and M.L. RAGHAVAN (840 United States of America)

Edition

Journal of the Mechanical Behavior of Biomedical Materials, Elsevier, Amsterdam, 2021, 1751-6161

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

20901 Industrial biotechnology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.042

RIV identification code

RIV/00216224:14110/21:00120077

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jmbbm.2020.104181

UT WoS

000608182400007

Keywords in English

Abdominal aortic aneurysm; Failure properties; Mechanical testing; Sample orientation

Abstract

V originále

Introduction: Biomechanical rupture risk assessment of abdominal aortic aneurysm (AAA) requires information about failure properties of aneurysmal tissue. There are large differences between reported values. Among others, studies vary in using either axially or circumferentially oriented samples. This study investigates the effect of sample orientation on failure properties. Methods: Aneurysmal tissues from 45 patients (11 females) were harvested during open AAA repair, cut into uniaxial samples (90) and tested mechanically within 3 h. If possible, the samples were cut in both axial (49 samples) and circumferential (41 samples) directions. Wall thickness, First Piola-Kirchhoff strength P-ult and ultimate tension T-ult were recorded. Influence of sample orientation and other clinical parameters were investigated using non parametric tests. Results: Medians of Pull (values 1100 kPa for circumferential vs. 715 kPa for axial direction, p < 10(-4)) and T-ult (17.4 N/cm in circumferential vs. 11.2 N/cm in axial direction, p < 10(-4)) were significantly higher in circumferential direction. For paired data, the median of difference was 411 kPa (p < 10(-3)) in P-ult, and 7.4 N/cm < 10(-4)) in T-ult in favor of circumferential direction. Conclusions: In this first study of anisotropy in AAA wall failure properties using paired comparisons, the strength in circumferential orientation was found to be higher than in axial orientation.

Links

NV17-29701A, research and development project

Name: Ischémií modifikovaný albumin a cirkulující mikroRNA jako nové technologie k monitorování tkáňové ischémie po cévních rekonstrukcích na břišní aortě

Citovat

POLZER, Stanislav, Vojtěch MAN, Robert VLACHOVSKÝ, Luboš KUBÍČEK, Jan KRACÍK, Robert STAFFA, Tomáš NOVOTNÝ, Jiří BURŠA and M.L. RAGHAVAN. Failure properties of abdominal aortic aneurysm tissue are orientation dependent. Journal of the Mechanical Behavior of Biomedical Materials. Elsevier: Amsterdam, 2021, vol. 114, FEB 2021, p. 1-7. ISSN 1751-6161. Available from: https://dx.doi.org/10.1016/j.jmbbm.2020.104181.

@article{1698685,
   author = {Polzer, Stanislav and Man, Vojtěch and Vlachovský, Robert and Kubíček, Luboš and Kracík, Jan and Staffa, Robert and Novotný, Tomáš and Burša, Jiří and Raghavan, M.L.},
   article_location = {Elsevier},
   article_number = {FEB 2021},
   doi = {http://dx.doi.org/10.1016/j.jmbbm.2020.104181},
   keywords = {Abdominal aortic aneurysm; Failure properties; Mechanical testing; Sample orientation},
   language = {eng},
   issn = {1751-6161},
   journal = {Journal of the Mechanical Behavior of Biomedical Materials},
   title = {Failure properties of abdominal aortic aneurysm tissue are orientation dependent},
   url = {https://www.sciencedirect.com/science/article/pii/S1751616120307232?via%3Dihub},
   volume = {114},
   year = {2021}
}

TY  - JOUR
ID  - 1698685
AU  - Polzer, Stanislav - Man, Vojtěch - Vlachovský, Robert - Kubíček, Luboš - Kracík, Jan - Staffa, Robert - Novotný, Tomáš - Burša, Jiří - Raghavan, M.L.
PY  - 2021
TI  - Failure properties of abdominal aortic aneurysm tissue are orientation dependent
JF  - Journal of the Mechanical Behavior of Biomedical Materials
VL  - 114
IS  - FEB 2021
SP  - 1-7
EP  - 1-7
PB  - Amsterdam
SN  - 17516161
KW  - Abdominal aortic aneurysm
KW  - Failure properties
KW  - Mechanical testing
KW  - Sample orientation
UR  - https://www.sciencedirect.com/science/article/pii/S1751616120307232?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S1751616120307232?via%3Dihub
N2  - Introduction: Biomechanical rupture risk assessment of abdominal aortic aneurysm (AAA) requires information about failure properties of aneurysmal tissue. There are large differences between reported values. Among others, studies vary in using either axially or circumferentially oriented samples. This study investigates the effect of sample orientation on failure properties. Methods: Aneurysmal tissues from 45 patients (11 females) were harvested during open AAA repair, cut into uniaxial samples (90) and tested mechanically within 3 h. If possible, the samples were cut in both axial (49 samples) and circumferential (41 samples) directions. Wall thickness, First Piola-Kirchhoff strength P-ult and ultimate tension T-ult were recorded. Influence of sample orientation and other clinical parameters were investigated using non parametric tests. Results: Medians of Pull (values 1100 kPa for circumferential vs. 715 kPa for axial direction, p < 10(-4)) and T-ult (17.4 N/cm in circumferential vs. 11.2 N/cm in axial direction, p < 10(-4)) were significantly higher in circumferential direction. For paired data, the median of difference was 411 kPa (p < 10(-3)) in P-ult, and 7.4 N/cm < 10(-4)) in T-ult in favor of circumferential direction. Conclusions: In this first study of anisotropy in AAA wall failure properties using paired comparisons, the strength in circumferential orientation was found to be higher than in axial orientation.
ER  -

POLZER, Stanislav, Vojtěch MAN, Robert VLACHOVSKÝ, Luboš KUBÍČEK, Jan KRACÍK, Robert STAFFA, Tomáš NOVOTNÝ, Jiří BURŠA and M.L. RAGHAVAN. Failure properties of abdominal aortic aneurysm tissue are orientation dependent. \textit{Journal of the Mechanical Behavior of Biomedical Materials}. Elsevier: Amsterdam, 2021, vol.~114, FEB 2021, p.~1-7. ISSN~1751-6161. Available from: https://dx.doi.org/10.1016/j.jmbbm.2020.104181.

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