Uveal melanoma - testing of abnormalities of chromosome 3 and 8
in the Czech Republic

J 2020

Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic

MATUŠKOVÁ, Veronika; Pavla HORŇÁČKOVÁ; Radoslava UHMANNOVÁ; Lenka ZLÁMALÍKOVÁ; Květoslava LIŠKOVÁ et. al.

Základní údaje

Originální název

Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic

Autoři

MATUŠKOVÁ, Veronika (203 Česká republika, garant, domácí); Pavla HORŇÁČKOVÁ (203 Česká republika, domácí); Radoslava UHMANNOVÁ (203 Česká republika); Lenka ZLÁMALÍKOVÁ (203 Česká republika, domácí); Květoslava LIŠKOVÁ (203 Česká republika, domácí); Michal UHER (203 Česká republika, domácí) a Eva VLKOVÁ (203 Česká republika, domácí)

Vydání

Biomedical Papers, Olomouc, Univerzita Palackého v Olomouci, 2020, 1213-8118

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30207 Ophthalmology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.245

Kód RIV

RIV/00216224:14110/20:00117059

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.5507/bp.2019.037

UT WoS

000604951200008

EID Scopus

2-s2.0-85097777757

Klíčová slova anglicky

uveal melanoma; chromosome 3; chromosome 8; CISH; FISH; progression-free survival

Štítky

14110219, 14110230, 14119612, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 1. 2021 09:55, Mgr. Tereza Miškechová

Anotace

V originále

Aim: The aim of this cytogenetic study is to confirm the significance of chromosome 3 loss (monosomy 3) and of the gain of chromosome 8 as prognostic markers in histopathological samples of enucleated eyes with uveal melanoma in the Czech population. Methods: This is a retrospective study of 52 enucleated eyes. Chromosome 3 and 8 status were tested by CISH, and in a few samples FISH was used. The correlation between monosomy 3 and gain of chromosome 8 and clinical features (histopathological type, size of the tumour) were evaluated. A follow up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was calculated. Results: There were 52 patients, 27 men (51.9%) and 25 women (48.1%) enrolled in our study group. The mean age was 63 ± 14 years. Loss of the one copy of chromosome 3 (monosomy 3) was detected in 26 (50.0%) patients, monosomy 8 was present in 34.6% of patients with monosomy 3. After 5 years there were no metastases in 82% of patients without monosomy 3 as opposed to 40% of patients with monosomy 3. We confirmed a statistically significant association between progression free survival (PFS) and the presence of monosomy 3 (P=0.017). The association between PFS and gain of chromosome 8 was significant as well (0.010). Conclusions: Our data showed the association of progression-free survival with the presence of monosomy 3 in uveal melanomas. We provided a good prognostic value of monosomy 3 in uveal melanoma.

Citovat

MATUŠKOVÁ, Veronika; Pavla HORŇÁČKOVÁ; Radoslava UHMANNOVÁ; Lenka ZLÁMALÍKOVÁ; Květoslava LIŠKOVÁ; Michal UHER a Eva VLKOVÁ. Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic. Biomedical Papers. Olomouc: Univerzita Palackého v Olomouci, 2020, roč. 164, č. 4, s. 401-409. ISSN 1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.037.

@article{1698697,
   author = {Matušková, Veronika and Horňáčková, Pavla and Uhmannová, Radoslava and Zlámalíková, Lenka and Lišková, Květoslava and Uher, Michal and Vlková, Eva},
   article_location = {Olomouc},
   article_number = {4},
   doi = {http://dx.doi.org/10.5507/bp.2019.037},
   keywords = {uveal melanoma; chromosome 3; chromosome 8; CISH; FISH; progression-free survival},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers},
   title = {Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166},
   volume = {164},
   year = {2020}
}

TY  - JOUR
ID  - 1698697
AU  - Matušková, Veronika - Horňáčková, Pavla - Uhmannová, Radoslava - Zlámalíková, Lenka - Lišková, Květoslava - Uher, Michal - Vlková, Eva
PY  - 2020
TI  - Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic
JF  - Biomedical Papers
VL  - 164
IS  - 4
SP  - 401-409
EP  - 401-409
PB  - Univerzita Palackého v Olomouci
SN  - 12138118
KW  - uveal melanoma
KW  - chromosome 3
KW  - chromosome 8
KW  - CISH
KW  - FISH
KW  - progression-free survival
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166
L2  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166
N2  - Aim: The aim of this cytogenetic study is to confirm the significance of chromosome 3 loss (monosomy 3) and of the gain of chromosome 8 as prognostic markers in histopathological samples of enucleated eyes with uveal melanoma in the Czech population. Methods: This is a retrospective study of 52 enucleated eyes. Chromosome 3 and 8 status were tested by CISH, and in a few samples FISH was used. The correlation between monosomy 3 and gain of chromosome 8 and clinical features (histopathological type, size of the tumour) were evaluated. A follow up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was calculated. Results: There were 52 patients, 27 men (51.9%) and 25 women (48.1%) enrolled in our study group. The mean age was 63 ± 14 years. Loss of the one copy of chromosome 3 (monosomy 3) was detected in 26 (50.0%) patients, monosomy 8 was present in 34.6% of patients with monosomy 3. After 5 years there were no metastases in 82% of patients without monosomy 3 as opposed to 40% of patients with monosomy 3. We confirmed a statistically significant association between progression free survival (PFS) and the presence of monosomy 3 (P=0.017). The association between PFS and gain of chromosome 8 was significant as well (0.010). Conclusions: Our data showed the association of progression-free survival with the presence of monosomy 3 in uveal melanomas. We provided a good prognostic value of monosomy 3 in uveal melanoma.
ER  -

MATUŠKOVÁ, Veronika; Pavla HORŇÁČKOVÁ; Radoslava UHMANNOVÁ; Lenka ZLÁMALÍKOVÁ; Květoslava LIŠKOVÁ; Michal UHER a Eva VLKOVÁ. Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2020, roč.~164, č.~4, s.~401-409. ISSN~1213-8118. Dostupné z: https://dx.doi.org/10.5507/bp.2019.037.

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