| MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Radoslava UHMANNOVÁ, Lenka ZLÁMALÍKOVÁ, Květoslava LIŠKOVÁ, Michal UHER and Eva VLKOVÁ. Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic. Biomedical Papers. Olomouc: Univerzita Palackého v Olomouci, 2020, vol. 164, No 4, p. 401-409. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2019.037. |
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@article{1698697,
author = {Matušková, Veronika and Horňáčková, Pavla and Uhmannová, Radoslava and Zlámalíková, Lenka and Lišková, Květoslava and Uher, Michal and Vlková, Eva},
article_location = {Olomouc},
article_number = {4},
doi = {http://dx.doi.org/10.5507/bp.2019.037},
keywords = {uveal melanoma; chromosome 3; chromosome 8; CISH; FISH; progression-free survival},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers},
title = {Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic},
url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166},
volume = {164},
year = {2020}
}
TY - JOUR
ID - 1698697
AU - Matušková, Veronika - Horňáčková, Pavla - Uhmannová, Radoslava - Zlámalíková, Lenka - Lišková, Květoslava - Uher, Michal - Vlková, Eva
PY - 2020
TI - Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic
JF - Biomedical Papers
VL - 164
IS - 4
SP - 401-409
EP - 401-409
PB - Univerzita Palackého v Olomouci
SN - 12138118
KW - uveal melanoma
KW - chromosome 3
KW - chromosome 8
KW - CISH
KW - FISH
KW - progression-free survival
UR - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166
L2 - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166
N2 - Aim: The aim of this cytogenetic study is to confirm the significance of chromosome 3 loss (monosomy 3) and of the gain of chromosome 8 as prognostic markers in histopathological samples of enucleated eyes with uveal melanoma in the Czech population. Methods: This is a retrospective study of 52 enucleated eyes. Chromosome 3 and 8 status were tested by CISH, and in a few samples FISH was used. The correlation between monosomy 3 and gain of chromosome 8 and clinical features (histopathological type, size of the tumour) were evaluated. A follow up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was calculated. Results: There were 52 patients, 27 men (51.9%) and 25 women (48.1%) enrolled in our study group. The mean age was 63 ± 14 years. Loss of the one copy of chromosome 3 (monosomy 3) was detected in 26 (50.0%) patients, monosomy 8 was present in 34.6% of patients with monosomy 3. After 5 years there were no metastases in 82% of patients without monosomy 3 as opposed to 40% of patients with monosomy 3. We confirmed a statistically significant association between progression free survival (PFS) and the presence of monosomy 3 (P=0.017). The association between PFS and gain of chromosome 8 was significant as well (0.010). Conclusions: Our data showed the association of progression-free survival with the presence of monosomy 3 in uveal melanomas. We provided a good prognostic value of monosomy 3 in uveal melanoma.
ER -
MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Radoslava UHMANNOVÁ, Lenka ZLÁMALÍKOVÁ, Květoslava LIŠKOVÁ, Michal UHER and Eva VLKOVÁ. Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2020, vol.~164, No~4, p.~401-409. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2019.037.
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