MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Radoslava UHMANNOVÁ, Lenka ZLÁMALÍKOVÁ, Květoslava LIŠKOVÁ, Michal UHER and Eva VLKOVÁ. Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic. Biomedical Papers. Olomouc: Univerzita Palackého v Olomouci, 2020, vol. 164, No 4, p. 401-409. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2019.037. |
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@article{1698697, author = {Matušková, Veronika and Horňáčková, Pavla and Uhmannová, Radoslava and Zlámalíková, Lenka and Lišková, Květoslava and Uher, Michal and Vlková, Eva}, article_location = {Olomouc}, article_number = {4}, doi = {http://dx.doi.org/10.5507/bp.2019.037}, keywords = {uveal melanoma; chromosome 3; chromosome 8; CISH; FISH; progression-free survival}, language = {eng}, issn = {1213-8118}, journal = {Biomedical Papers}, title = {Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic}, url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166}, volume = {164}, year = {2020} }
TY - JOUR ID - 1698697 AU - Matušková, Veronika - Horňáčková, Pavla - Uhmannová, Radoslava - Zlámalíková, Lenka - Lišková, Květoslava - Uher, Michal - Vlková, Eva PY - 2020 TI - Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic JF - Biomedical Papers VL - 164 IS - 4 SP - 401-409 EP - 401-409 PB - Univerzita Palackého v Olomouci SN - 12138118 KW - uveal melanoma KW - chromosome 3 KW - chromosome 8 KW - CISH KW - FISH KW - progression-free survival UR - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166 L2 - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-2166 N2 - Aim: The aim of this cytogenetic study is to confirm the significance of chromosome 3 loss (monosomy 3) and of the gain of chromosome 8 as prognostic markers in histopathological samples of enucleated eyes with uveal melanoma in the Czech population. Methods: This is a retrospective study of 52 enucleated eyes. Chromosome 3 and 8 status were tested by CISH, and in a few samples FISH was used. The correlation between monosomy 3 and gain of chromosome 8 and clinical features (histopathological type, size of the tumour) were evaluated. A follow up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was calculated. Results: There were 52 patients, 27 men (51.9%) and 25 women (48.1%) enrolled in our study group. The mean age was 63 ± 14 years. Loss of the one copy of chromosome 3 (monosomy 3) was detected in 26 (50.0%) patients, monosomy 8 was present in 34.6% of patients with monosomy 3. After 5 years there were no metastases in 82% of patients without monosomy 3 as opposed to 40% of patients with monosomy 3. We confirmed a statistically significant association between progression free survival (PFS) and the presence of monosomy 3 (P=0.017). The association between PFS and gain of chromosome 8 was significant as well (0.010). Conclusions: Our data showed the association of progression-free survival with the presence of monosomy 3 in uveal melanomas. We provided a good prognostic value of monosomy 3 in uveal melanoma. ER -
MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Radoslava UHMANNOVÁ, Lenka ZLÁMALÍKOVÁ, Květoslava LIŠKOVÁ, Michal UHER and Eva VLKOVÁ. Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic. \textit{Biomedical Papers}. Olomouc: Univerzita Palackého v Olomouci, 2020, vol.~164, No~4, p.~401-409. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2019.037.
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