Detailed Information on Publication Record
2020
Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic
MATUŠKOVÁ, Veronika, Pavla HORŇÁČKOVÁ, Radoslava UHMANNOVÁ, Lenka ZLÁMALÍKOVÁ, Květoslava LIŠKOVÁ et. al.Basic information
Original name
Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic
Authors
MATUŠKOVÁ, Veronika (203 Czech Republic, guarantor, belonging to the institution), Pavla HORŇÁČKOVÁ (203 Czech Republic, belonging to the institution), Radoslava UHMANNOVÁ (203 Czech Republic), Lenka ZLÁMALÍKOVÁ (203 Czech Republic, belonging to the institution), Květoslava LIŠKOVÁ (203 Czech Republic, belonging to the institution), Michal UHER (203 Czech Republic, belonging to the institution) and Eva VLKOVÁ (203 Czech Republic, belonging to the institution)
Edition
Biomedical Papers, Olomouc, Univerzita Palackého v Olomouci, 2020, 1213-8118
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30207 Ophthalmology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.245
RIV identification code
RIV/00216224:14110/20:00117059
Organization unit
Faculty of Medicine
UT WoS
000604951200008
Keywords in English
uveal melanoma; chromosome 3; chromosome 8; CISH; FISH; progression-free survival
Tags
International impact, Reviewed
Změněno: 27/1/2021 09:55, Mgr. Tereza Miškechová
Abstract
V originále
Aim: The aim of this cytogenetic study is to confirm the significance of chromosome 3 loss (monosomy 3) and of the gain of chromosome 8 as prognostic markers in histopathological samples of enucleated eyes with uveal melanoma in the Czech population. Methods: This is a retrospective study of 52 enucleated eyes. Chromosome 3 and 8 status were tested by CISH, and in a few samples FISH was used. The correlation between monosomy 3 and gain of chromosome 8 and clinical features (histopathological type, size of the tumour) were evaluated. A follow up for the detection of metastases was conducted in all patients. The statistical significance of chromosomal abnormalities as a prognostic factor for the development of metastases was calculated. Results: There were 52 patients, 27 men (51.9%) and 25 women (48.1%) enrolled in our study group. The mean age was 63 ± 14 years. Loss of the one copy of chromosome 3 (monosomy 3) was detected in 26 (50.0%) patients, monosomy 8 was present in 34.6% of patients with monosomy 3. After 5 years there were no metastases in 82% of patients without monosomy 3 as opposed to 40% of patients with monosomy 3. We confirmed a statistically significant association between progression free survival (PFS) and the presence of monosomy 3 (P=0.017). The association between PFS and gain of chromosome 8 was significant as well (0.010). Conclusions: Our data showed the association of progression-free survival with the presence of monosomy 3 in uveal melanomas. We provided a good prognostic value of monosomy 3 in uveal melanoma.