ČAJÁNEK, Lukáš. A play on cilia beating. Journal of Biological Chemistry. Bethesda, USA: Amer. Soc. Biochem. Mol. Biol., 2020, vol. 295, No 42, p. 14260-14261. ISSN 0021-9258. Available from: https://dx.doi.org/10.1074/jbc.H120.015887.
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Basic information
Original name A play on cilia beating
Authors ČAJÁNEK, Lukáš (203 Czech Republic, guarantor, belonging to the institution).
Edition Journal of Biological Chemistry, Bethesda, USA, Amer. Soc. Biochem. Mol. Biol. 2020, 0021-9258.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10608 Biochemistry and molecular biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 5.157
RIV identification code RIV/00216224:14110/20:00114499
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1074/jbc.H120.015887
UT WoS 000586428700002
Keywords in English cilia beating
Tags rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 24/11/2020 10:21.
Abstract
Motile cilia, hairlike structures present on the cell surface, have a well-appreciated role in human physiology, including sweeping mucus, dirt and debris out of the respiratory tract. However, we are only beginning to understand the mechanisms governing cilia growth, maintenance and function. In this issue, Arora et al. reveal new details about the control of cilia growth. They identify a previously unrecognized connection between adenylate cyclase 6 (AC6), a cilia signaling mediator, and the autophagy-mediated regulation of motile cilia length via kinesin Kif19a, a regulator of cilia length. These findings provide new insights into motile cilia biology and may lead to novel ciliopathy treatments.
Links
GA19-05244S, research and development projectName: Molekulární aspekty ciliogeneze: zaměření na Tau Tubulin Kinázu 2
Investor: Czech Science Foundation
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