Revision and Update of the Consensus Definitions of Invasive
Fungal Disease From the European Organization for Research and
Treatment of Cancer and the Mycoses Study Group Education and
Research Consortium

J 2020

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium

DONNELLY, J. P., S. C. CHEN, C. A. KAUFFMAN, W. J. STEINBACH, J. W. BADDLEY et. al.

Basic information

Original name

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium

Authors

DONNELLY, J. P. (guarantor), S. C. CHEN, C. A. KAUFFMAN, W. J. STEINBACH, J. W. BADDLEY, P. E. VERWEIJ, C. J. CLANCY, J. R. WINGARD, S. R. LOCKHART, A. H. GROLL, T. C.. SORRELL, M. BASSETTI, H. AKAN, B. D. ALEXANDER, D. ANDES, E. AZOULAY, R. BIALEK, R. W. BRADSHER, S. BRETAGNE, T. CALANDRA, A. M. CALIENDO, E. CASTAGNOLA, M. CRUCIANI, M. CUENCA-ESTRELLA, C. F. DECKER, S. R. DESAI, B. FISHER, T. HARRISON, C. P. HEUSSEL, H. E. JENSEN, C. C. KIBBLER, D. P. KONTOYIANNIS, B. J. KULLBERG, K. LAGROU, F. LAMOTH, T. LEHRNBECHER, J. LOEFFLER, O. LORTHOLARY, J. MAERTENS, O.. MARCHETTI, K. A. MARR, H. MASUR, J. F. MEIS, C. O. MORRISEY, M. NUCCI, L. OSTROSKY-ZEICHNER, L. PAGANO, T. F. PATTERSON, J. R. PERFECT, Zdeněk RÁČIL (203 Czech Republic, belonging to the institution), E. ROILIDES, M. RUHNKE, C. S. PROKOP, S. SHOHAM, M. A. SLAVIN, D. A. STEVENS, G. R. THOMPSON, J. A. VAZQUEZ, C. VISCOLI, T. J. WALSH, A. WARRIS, L. J. WHEAT, P. L. WHITE, T. E. ZAOUTIS and P. G. PAPPAS

Edition

Clinical Infectious Diseases, Chicago, USA, The University of Chicago Press, 2020, 1058-4838

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 9.079

RIV identification code

RIV/00216224:14110/20:00117062

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1093/cid/ciz1008

UT WoS

000582709700003

Keywords in English

consensus; definitions; invasive fungal diseases; diagnosis; research

Abstract

V originále

Background Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, and undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients of stem cell or solid organ transplants. With newer diagnostic techniques available, it was clear that an update of these definitions was essential. Methods To achieve this, 10 working groups looked closely at imaging, laboratory diagnosis, and special populations at risk of IFD. A final version of the manuscript was agreed upon after the groups' findings were presented at a scientific symposium and after a 3-month period for public comment. There were several rounds of discussion before a final version of the manuscript was approved. Results There is no change in the classifications of "proven," "probable," and "possible" IFD, although the definition of "probable" has been expanded and the scope of the category "possible" has been diminished. The category of proven IFD can apply to any patient, regardless of whether the patient is immunocompromised. The probable and possible categories are proposed for immunocompromised patients only, except for endemic mycoses. Conclusions These updated definitions of IFDs should prove applicable in clinical, diagnostic, and epidemiologic research of a broader range of patients at high-risk. European Organization for Research and Treatment of Cancer and the Mycoses Study Group definitions for probable invasive fungal disease now include solid organ transplant, hematologic malignancy, graft-versus-host disease, the reverse halo sign, revised thresholds for galactomannan, Aspergillus polymerase chain reaction, and definitions for candidiasis, cryptococcosis, non-human immunodeficiency viirus-associated pneumocystosis, and endemic mycoses.

Citovat

DONNELLY, J. P., S. C. CHEN, C. A. KAUFFMAN, W. J. STEINBACH, J. W. BADDLEY, P. E. VERWEIJ, C. J. CLANCY, J. R. WINGARD, S. R. LOCKHART, A. H. GROLL, T. C.. SORRELL, M. BASSETTI, H. AKAN, B. D. ALEXANDER, D. ANDES, E. AZOULAY, R. BIALEK, R. W. BRADSHER, S. BRETAGNE, T. CALANDRA, A. M. CALIENDO, E. CASTAGNOLA, M. CRUCIANI, M. CUENCA-ESTRELLA, C. F. DECKER, S. R. DESAI, B. FISHER, T. HARRISON, C. P. HEUSSEL, H. E. JENSEN, C. C. KIBBLER, D. P. KONTOYIANNIS, B. J. KULLBERG, K. LAGROU, F. LAMOTH, T. LEHRNBECHER, J. LOEFFLER, O. LORTHOLARY, J. MAERTENS, O.. MARCHETTI, K. A. MARR, H. MASUR, J. F. MEIS, C. O. MORRISEY, M. NUCCI, L. OSTROSKY-ZEICHNER, L. PAGANO, T. F. PATTERSON, J. R. PERFECT, Zdeněk RÁČIL, E. ROILIDES, M. RUHNKE, C. S. PROKOP, S. SHOHAM, M. A. SLAVIN, D. A. STEVENS, G. R. THOMPSON, J. A. VAZQUEZ, C. VISCOLI, T. J. WALSH, A. WARRIS, L. J. WHEAT, P. L. WHITE, T. E. ZAOUTIS and P. G. PAPPAS. Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clinical Infectious Diseases. Chicago, USA: The University of Chicago Press, 2020, vol. 71, No 6, p. 1367-1376. ISSN 1058-4838. Available from: https://dx.doi.org/10.1093/cid/ciz1008.

@article{1698798,
   author = {Donnelly, J. P. and Chen, S. C. and Kauffman, C. A. and Steinbach, W. J. and Baddley, J. W. and Verweij, P. E. and Clancy, C. J. and Wingard, J. R. and Lockhart, S. R. and Groll, A. H. and Sorrell, T. C.. and Bassetti, M. and Akan, H. and Alexander, B. D. and Andes, D. and Azoulay, E. and Bialek, R. and Bradsher, R. W. and Bretagne, S. and Calandra, T. and Caliendo, A. M. and Castagnola, E. and Cruciani, M. and CuencaandEstrella, M. and Decker, C. F. and Desai, S. R. and Fisher, B. and Harrison, T. and Heussel, C. P. and Jensen, H. E. and Kibbler, C. C. and Kontoyiannis, D. P. and Kullberg, B. J. and Lagrou, K. and Lamoth, F. and Lehrnbecher, T. and Loeffler, J. and Lortholary, O. and Maertens, J. and Marchetti, O.. and Marr, K. A. and Masur, H. and Meis, J. F. and Morrisey, C. O. and Nucci, M. and OstroskyandZeichner, L. and Pagano, L. and Patterson, T. F. and Perfect, J. R. and Ráčil, Zdeněk and Roilides, E. and Ruhnke, M. and Prokop, C. S. and Shoham, S. and Slavin, M. A. and Stevens, D. A. and Thompson, G. R. and Vazquez, J. A. and Viscoli, C. and Walsh, T. J. and Warris, A. and Wheat, L. J. and White, P. L. and Zaoutis, T. E. and Pappas, P. G.},
   article_location = {Chicago, USA},
   article_number = {6},
   doi = {http://dx.doi.org/10.1093/cid/ciz1008},
   keywords = {consensus; definitions; invasive fungal diseases; diagnosis; research},
   language = {eng},
   issn = {1058-4838},
   journal = {Clinical Infectious Diseases},
   title = {Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium},
   url = {https://watermark.silverchair.com/ciz1008.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArAwggKsBgkqhkiG9w0BBwagggKdMIICmQIBADCCApIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM_tCdNIwNkMPbaqGKAgEQgIICY-MRWU8BzxG9L5hO1OjazR8yFcnzSS0UPCfJTfBpu_2wgG},
   volume = {71},
   year = {2020}
}

TY  - JOUR
ID  - 1698798
AU  - Donnelly, J. P. - Chen, S. C. - Kauffman, C. A. - Steinbach, W. J. - Baddley, J. W. - Verweij, P. E. - Clancy, C. J. - Wingard, J. R. - Lockhart, S. R. - Groll, A. H. - Sorrell, T. C.. - Bassetti, M. - Akan, H. - Alexander, B. D. - Andes, D. - Azoulay, E. - Bialek, R. - Bradsher, R. W. - Bretagne, S. - Calandra, T. - Caliendo, A. M. - Castagnola, E. - Cruciani, M. - Cuenca-Estrella, M. - Decker, C. F. - Desai, S. R. - Fisher, B. - Harrison, T. - Heussel, C. P. - Jensen, H. E. - Kibbler, C. C. - Kontoyiannis, D. P. - Kullberg, B. J. - Lagrou, K. - Lamoth, F. - Lehrnbecher, T. - Loeffler, J. - Lortholary, O. - Maertens, J. - Marchetti, O.. - Marr, K. A. - Masur, H. - Meis, J. F. - Morrisey, C. O. - Nucci, M. - Ostrosky-Zeichner, L. - Pagano, L. - Patterson, T. F. - Perfect, J. R. - Ráčil, Zdeněk - Roilides, E. - Ruhnke, M. - Prokop, C. S. - Shoham, S. - Slavin, M. A. - Stevens, D. A. - Thompson, G. R. - Vazquez, J. A. - Viscoli, C. - Walsh, T. J. - Warris, A. - Wheat, L. J. - White, P. L. - Zaoutis, T. E. - Pappas, P. G.
PY  - 2020
TI  - Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium
JF  - Clinical Infectious Diseases
VL  - 71
IS  - 6
SP  - 1367-1376
EP  - 1367-1376
PB  - The University of Chicago Press
SN  - 10584838
KW  - consensus
KW  - definitions
KW  - invasive fungal diseases
KW  - diagnosis
KW  - research
UR  - https://watermark.silverchair.com/ciz1008.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArAwggKsBgkqhkiG9w0BBwagggKdMIICmQIBADCCApIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM_tCdNIwNkMPbaqGKAgEQgIICY-MRWU8BzxG9L5hO1OjazR8yFcnzSS0UPCfJTfBpu_2wgG
L2  - https://watermark.silverchair.com/ciz1008.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArAwggKsBgkqhkiG9w0BBwagggKdMIICmQIBADCCApIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM_tCdNIwNkMPbaqGKAgEQgIICY-MRWU8BzxG9L5hO1OjazR8yFcnzSS0UPCfJTfBpu_2wgG
N2  - Background Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, and undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients of stem cell or solid organ transplants. With newer diagnostic techniques available, it was clear that an update of these definitions was essential. Methods To achieve this, 10 working groups looked closely at imaging, laboratory diagnosis, and special populations at risk of IFD. A final version of the manuscript was agreed upon after the groups' findings were presented at a scientific symposium and after a 3-month period for public comment. There were several rounds of discussion before a final version of the manuscript was approved. Results There is no change in the classifications of "proven," "probable," and "possible" IFD, although the definition of "probable" has been expanded and the scope of the category "possible" has been diminished. The category of proven IFD can apply to any patient, regardless of whether the patient is immunocompromised. The probable and possible categories are proposed for immunocompromised patients only, except for endemic mycoses. Conclusions These updated definitions of IFDs should prove applicable in clinical, diagnostic, and epidemiologic research of a broader range of patients at high-risk. European Organization for Research and Treatment of Cancer and the Mycoses Study Group definitions for probable invasive fungal disease now include solid organ transplant, hematologic malignancy, graft-versus-host disease, the reverse halo sign, revised thresholds for galactomannan, Aspergillus polymerase chain reaction, and definitions for candidiasis, cryptococcosis, non-human immunodeficiency viirus-associated pneumocystosis, and endemic mycoses.
ER  -

DONNELLY, J. P., S. C. CHEN, C. A. KAUFFMAN, W. J. STEINBACH, J. W. BADDLEY, P. E. VERWEIJ, C. J. CLANCY, J. R. WINGARD, S. R. LOCKHART, A. H. GROLL, T. C.. SORRELL, M. BASSETTI, H. AKAN, B. D. ALEXANDER, D. ANDES, E. AZOULAY, R. BIALEK, R. W. BRADSHER, S. BRETAGNE, T. CALANDRA, A. M. CALIENDO, E. CASTAGNOLA, M. CRUCIANI, M. CUENCA-ESTRELLA, C. F. DECKER, S. R. DESAI, B. FISHER, T. HARRISON, C. P. HEUSSEL, H. E. JENSEN, C. C. KIBBLER, D. P. KONTOYIANNIS, B. J. KULLBERG, K. LAGROU, F. LAMOTH, T. LEHRNBECHER, J. LOEFFLER, O. LORTHOLARY, J. MAERTENS, O.. MARCHETTI, K. A. MARR, H. MASUR, J. F. MEIS, C. O. MORRISEY, M. NUCCI, L. OSTROSKY-ZEICHNER, L. PAGANO, T. F. PATTERSON, J. R. PERFECT, Zdeněk RÁČIL, E. ROILIDES, M. RUHNKE, C. S. PROKOP, S. SHOHAM, M. A. SLAVIN, D. A. STEVENS, G. R. THOMPSON, J. A. VAZQUEZ, C. VISCOLI, T. J. WALSH, A. WARRIS, L. J. WHEAT, P. L. WHITE, T. E. ZAOUTIS and P. G. PAPPAS. Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. \textit{Clinical Infectious Diseases}. Chicago, USA: The University of Chicago Press, 2020, vol.~71, No~6, p.~1367-1376. ISSN~1058-4838. Available from: https://dx.doi.org/10.1093/cid/ciz1008.

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