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@article{1699499,
author = {Hampl, Marek and Dumková, Jana and Kavková, Michaela and Dosedělová, Hana and Bryjová, Anna and Zahradníček, Oldřich and Pyszko, Martin and Macholan, Miloš and Zikmund, Tomáš and Kaiser, Jozef and Buchtová, marcela},
article_location = {Lausanne},
article_number = {July 2020},
doi = {http://dx.doi.org/10.3389/fcell.2020.00572},
keywords = {secondary palate; SHH; primary cilia; skeletogenesis; chameleon; reptile Frontiers},
language = {eng},
issn = {2296-634X},
journal = {Frontiers in Cell and Developmental Biology},
title = {Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon},
url = {https://www.frontiersin.org/articles/10.3389/fcell.2020.00572/full},
volume = {8},
year = {2020}
}
TY - JOUR
ID - 1699499
AU - Hampl, Marek - Dumková, Jana - Kavková, Michaela - Dosedělová, Hana - Bryjová, Anna - Zahradníček, Oldřich - Pyszko, Martin - Macholan, Miloš - Zikmund, Tomáš - Kaiser, Jozef - Buchtová, marcela
PY - 2020
TI - Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon
JF - Frontiers in Cell and Developmental Biology
VL - 8
IS - July 2020
SP - 1-29
EP - 1-29
PB - Frontiers Media S.A.
SN - 2296634X
KW - secondary palate
KW - SHH
KW - primary cilia
KW - skeletogenesis
KW - chameleon
KW - reptile Frontiers
UR - https://www.frontiersin.org/articles/10.3389/fcell.2020.00572/full
L2 - https://www.frontiersin.org/articles/10.3389/fcell.2020.00572/full
N2 - Secondary palate development is characterized by the formation of two palatal shelves on the maxillary prominences, which fuse in the midline in mammalian embryos. However, in reptilian species, such as turtles, crocodilians, and lizards, the palatal shelves of the secondary palate develop to a variable extent and morphology. While in most Squamates, the palate is widely open, crocodilians develop a fully closed secondary palate. Here, we analyzed developmental processes that underlie secondary palate formation in chameleons, where large palatal shelves extend horizontally toward the midline. The growth of the palatal shelves continued during post-hatching stages and closure of the secondary palate can be observed in several adult animals. The massive proliferation of a multilayered oral epithelium and mesenchymal cells in the dorsal part of the palatal shelves underlined the initiation of their horizontal outgrowth, and was decreased later in development. The polarized cellular localization of primary cilia and Sonic hedgehog protein was associated with horizontal growth of the palatal shelves. Moreover, the development of large palatal shelves, supported by the pterygoid and palatine bones, was coupled with the shift in Meox2, Msx1, and Pax9 gene expression along the rostro-caudal axis. In conclusion, our results revealed distinctive developmental processes that contribute to the expansion and closure of the secondary palate in chameleons and highlighted divergences in palate formation across amniote species.
ER -
HAMPL, Marek, Jana DUMKOVÁ, Michaela KAVKOVÁ, Hana DOSEDĚLOVÁ, Anna BRYJOVÁ, Oldřich ZAHRADNÍČEK, Martin PYSZKO, Miloš MACHOLAN, Tomáš ZIKMUND, Jozef KAISER and marcela BUCHTOVÁ. Polarized Sonic Hedgehog Protein Localization and a Shift in the Expression of Region-Specific Molecules Is Associated With the Secondary Palate Development in the Veiled Chameleon. \textit{Frontiers in Cell and Developmental Biology}. Lausanne: Frontiers Media S.A., 2020, vol.~8, July 2020, p.~1-29. ISSN~2296-634X. Available from: https://dx.doi.org/10.3389/fcell.2020.00572.
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