ŠULCOVÁ, Marie, Oldrich ZAHRADNICEK, Jana DUMKOVÁ, Hana DOSEDELOVA, Jan KŘIVÁNEK, Marek HAMPL, Michaela KAVKOVA, Tomas ZIKMUND, Martina GREGOROVICOVA, David SEDMERA, Jozef KAISER, Abigail S. TUCKER and Marcela BUCHTOVÁ. Developmental mechanisms driving complex tooth shape in reptiles. Developmental dynamics. Hoboken: Wiley, vol. 249, No 4, p. 441-464. ISSN 1058-8388. doi:10.1002/dvdy.138. 2020.
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Basic information
Original name Developmental mechanisms driving complex tooth shape in reptiles
Authors ŠULCOVÁ, Marie (203 Czech Republic, belonging to the institution), Oldrich ZAHRADNICEK, Jana DUMKOVÁ (203 Czech Republic, belonging to the institution), Hana DOSEDELOVA, Jan KŘIVÁNEK (203 Czech Republic, belonging to the institution), Marek HAMPL (203 Czech Republic, belonging to the institution), Michaela KAVKOVA, Tomas ZIKMUND, Martina GREGOROVICOVA, David SEDMERA, Jozef KAISER, Abigail S. TUCKER and Marcela BUCHTOVÁ (203 Czech Republic, guarantor, belonging to the institution).
Edition Developmental dynamics, Hoboken, Wiley, 2020, 1058-8388.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10602 Biology , Evolutionary biology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.780
RIV identification code RIV/00216224:14310/20:00114512
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1002/dvdy.138
UT WoS 000502529500001
Keywords in English chameleon; crocodile; enamel ridge; gecko; matriptase; Na; K-ATPase; nuclei shape; SHH; tooth shape
Tags 14110517, CF CELLIM, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 17/2/2023 12:16.
Abstract
Background In mammals, odontogenesis is regulated by transient signaling centers known as enamel knots (EKs), which drive the dental epithelium shaping. However, the developmental mechanisms contributing to formation of complex tooth shape in reptiles are not fully understood. Here, we aim to elucidate whether signaling organizers similar to EKs appear during reptilian odontogenesis and how enamel ridges are formed. Results Morphological structures resembling the mammalian EK were found during reptile odontogenesis. Similar to mammalian primary EKs, they exhibit the presence of apoptotic cells and no proliferating cells. Moreover, expression of mammalian EK-specific molecules (SHH, FGF4, and ST14) and GLI2-negative cells were found in reptilian EK-like areas. 3D analysis of the nucleus shape revealed distinct rearrangement of the cells associated with enamel groove formation. This process was associated with ultrastructural changes and lipid droplet accumulation in the cells directly above the forming ridge, accompanied by alteration of membranous molecule expression (Na/K-ATPase) and cytoskeletal rearrangement (F-actin). Conclusions The final complex shape of reptilian teeth is orchestrated by a combination of changes in cell signaling, cell shape, and cell rearrangement. All these factors contribute to asymmetry in the inner enamel epithelium development, enamel deposition, ultimately leading to the formation of characteristic enamel ridges.
Links
GA17-14886S, research and development projectName: Molekulární a buněčná dynamika rozhraní zubu a kosti u modelových druhů s akrodontní, pleurodontní a tekodontní denticí
Investor: Czech Science Foundation
LM2015062, research and development projectName: Národní infrastruktura pro biologické a medicínské zobrazování
Investor: Ministry of Education, Youth and Sports of the CR
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
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