Detailed Information on Publication Record
2020
High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task
PAIL, Martin, Jan CIMBALNIK, Robert ROMAN, Pavel DANIEL, Daniel Joel SHAW et. al.Basic information
Original name
High frequency oscillations in epileptic and non-epileptic human hippocampus during a cognitive task
Authors
PAIL, Martin (203 Czech Republic, guarantor, belonging to the institution), Jan CIMBALNIK (203 Czech Republic), Robert ROMAN (203 Czech Republic, belonging to the institution), Pavel DANIEL (203 Czech Republic, belonging to the institution), Daniel Joel SHAW (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution), Jan CHRASTINA (203 Czech Republic, belonging to the institution) and Milan BRÁZDIL (203 Czech Republic, belonging to the institution)
Edition
Scientific reports, LONDON, NATURE PUBLISHING GROUP, 2020, 2045-2322
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
Germany
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.379
RIV identification code
RIV/00216224:14110/20:00117112
Organization unit
Faculty of Medicine
UT WoS
000586485700005
Keywords in English
epileptic and non-epileptic human hippocampus; cognitive task
Tags
International impact, Reviewed
Změněno: 23/2/2021 12:56, Mgr. Tereza Miškechová
Abstract
V originále
Hippocampal high-frequency electrographic activity (HFOs) represents one of the major discoveries not only in epilepsy research but also in cognitive science over the past few decades. A fundamental challenge, however, has been the fact that physiological HFOs associated with normal brain function overlap in frequency with pathological HFOs. We investigated the impact of a cognitive task on HFOs with the aim of improving differentiation between epileptic and non-epileptic hippocampi in humans. Hippocampal activity was recorded with depth electrodes in 15 patients with focal epilepsy during a resting period and subsequently during a cognitive task. HFOs in ripple and fast ripple frequency ranges were evaluated in both conditions, and their rate, spectral entropy, relative amplitude and duration were compared in epileptic and non-epileptic hippocampi. The similarity of HFOs properties recorded at rest in epileptic and non-epileptic hippocampi suggests that they cannot be used alone to distinguish between hippocampi. However, both ripples and fast ripples were observed with higher rates, higher relative amplitudes and longer durations at rest as well as during a cognitive task in epileptic compared with non-epileptic hippocampi. Moreover, during a cognitive task, significant reductions of HFOs rates were found in epileptic hippocampi. These reductions were not observed in non-epileptic hippocampi. Our results indicate that although both hippocampi generate HFOs with similar features that probably reflect non-pathological phenomena, it is possible to differentiate between epileptic and non-epileptic hippocampi using a simple odd-ball task.
Links
| LQ1601, research and development project |
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