How immune-cell fate and function are determined by metabolic
pathway choice The bioenergetics underlying the immune response

J 2021

How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response

HORTOVÁ KOHOUTKOVÁ, Marcela, Petra LÁZNIČKOVÁ and Jan FRIČ

Basic information

Original name

How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response

Authors

HORTOVÁ KOHOUTKOVÁ, Marcela (203 Czech Republic), Petra LÁZNIČKOVÁ (203 Czech Republic, belonging to the institution) and Jan FRIČ (203 Czech Republic, guarantor)

Edition

BioEssays, Hoboken, Wiley, 2021, 0265-9247

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.653

RIV identification code

RIV/00216224:14110/21:00120840

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/bies.202000067

UT WoS

000589588300001

Keywords in English

energy demand; immune-cell polarization; immunometabolism; nutrient availability

Abstract

V originále

Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such "immunometabolism" is governed through intermediate metabolites, and has a vital role in regulating immune-cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune-cell types gain a sufficient energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune-cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored.

Links

MUNI/A/1325/2020, interní kód MU

Name: Biomedicínské vědy

Investor: Masaryk University

Citovat

HORTOVÁ KOHOUTKOVÁ, Marcela, Petra LÁZNIČKOVÁ and Jan FRIČ. How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response. BioEssays. Hoboken: Wiley, 2021, vol. 43, No 2, p. 1-15. ISSN 0265-9247. Available from: https://dx.doi.org/10.1002/bies.202000067.

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   author = {Hortová Kohoutková, Marcela and Lázničková, Petra and Frič, Jan},
   article_location = {Hoboken},
   article_number = {2},
   doi = {http://dx.doi.org/10.1002/bies.202000067},
   keywords = {energy demand; immune-cell polarization; immunometabolism; nutrient availability},
   language = {eng},
   issn = {0265-9247},
   journal = {BioEssays},
   title = {How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response},
   url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202000067},
   volume = {43},
   year = {2021}
}

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PB  - Wiley
SN  - 02659247
KW  - energy demand
KW  - immune-cell polarization
KW  - immunometabolism
KW  - nutrient availability
UR  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202000067
L2  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bies.202000067
N2  - Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such "immunometabolism" is governed through intermediate metabolites, and has a vital role in regulating immune-cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune-cell types gain a sufficient energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune-cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored.
ER  -

HORTOVÁ KOHOUTKOVÁ, Marcela, Petra LÁZNIČKOVÁ and Jan FRIČ. How immune-cell fate and function are determined by metabolic pathway choice The bioenergetics underlying the immune response. \textit{BioEssays}. Hoboken: Wiley, 2021, vol.~43, No~2, p.~1-15. ISSN~0265-9247. Available from: https://dx.doi.org/10.1002/bies.202000067.

Detailed Information on Publication Record