Therapeutic Use of Bioengineered Materials for Myocardial
Infarction

C 2019

Therapeutic Use of Bioengineered Materials for Myocardial Infarction

SEDLÁKOVÁ, Veronika, Marc RUEL and Erik SUURONEN

Basic information

Original name

Therapeutic Use of Bioengineered Materials for Myocardial Infarction

Authors

SEDLÁKOVÁ, Veronika, Marc RUEL and Erik SUURONEN

Edition

Cham, Nanoengineering Materials for Biomedical Uses, p. 161-193, 33 pp. 1. 2019

Publisher

Springer

Other information

Language

English

Type of outcome

Kapitola resp. kapitoly v odborné knize

Field of Study

30400 3.4 Medical biotechnology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Publication form

printed version "print"

References:

URL

Organization unit

Faculty of Medicine

ISBN

978-3-030-31260-2

DOI

http://dx.doi.org/10.1007/978-3-030-31261-9_9

Keywords in English

Regenerative Medicine Tissue Engineering Biomimetic Composites Nanomaterials for Biomedicine Biocompatible Nanomaterials Engineering of Materials for Biocompatibility Nanostructures for Repair Heart Tissue Regeneration

Abstract

V originále

Cardiovascular disease is a leading cause of worldwide mortality. Despite the success of current therapies for acute myocardial infarction (MI), many patients still suffer irreversible damage, and the prevalence of heart failure is growing. After MI, the extracellular matrix (ECM) of the damaged myocardium is modified to produce scar tissue. This remodeling reduces the efficacy of therapies and also hinders endogenous repair mechanisms. Therefore, a strategy to prevent adverse remodeling and provide a suitable ECM environment that supports cells, tissue repair and functional restoration may lead to a superior therapeutic outcome in MI patients. Bioengineered materials are an attractive approach for achieving this. Herein, we review current research on materials that can act as a biomimetic matrix for supporting cellular repair in the post-MI heart. We also examine how nanomaterials are being used to treat the damaged heart. Finally, we provide an overview of the breakthroughs and limitations of biomaterial therapies for cardiac repair.

Citovat

SEDLÁKOVÁ, Veronika, Marc RUEL and Erik SUURONEN. Therapeutic Use of Bioengineered Materials for Myocardial Infarction. In Alarcon E., Ahumada M. (eds.). Nanoengineering Materials for Biomedical Uses. Cham: Springer, 2019, p. 161-193. 1. ISBN 978-3-030-31260-2. Available from: https://dx.doi.org/10.1007/978-3-030-31261-9_9.

@inbook{1703818,
   author = {Sedláková, Veronika and Ruel, Marc and Suuronen, Erik},
   address = {Cham},
   booktitle = {Nanoengineering Materials for Biomedical Uses},
   doi = {http://dx.doi.org/10.1007/978-3-030-31261-9_9},
   editor = {Alarcon E., Ahumada M. (eds.)},
   keywords = {Regenerative Medicine Tissue Engineering Biomimetic Composites Nanomaterials for Biomedicine Biocompatible Nanomaterials Engineering of Materials for Biocompatibility Nanostructures for Repair Heart Tissue Regeneration},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Cham},
   isbn = {978-3-030-31260-2},
   pages = {161-193},
   publisher = {Springer},
   title = {Therapeutic Use of Bioengineered Materials for Myocardial Infarction},
   url = {https://link.springer.com/chapter/10.1007/978-3-030-31261-9_9},
   year = {2019}
}

TY  - CHAP
ID  - 1703818
AU  - Sedláková, Veronika - Ruel, Marc - Suuronen, Erik
PY  - 2019
TI  - Therapeutic Use of Bioengineered Materials for Myocardial Infarction
VL  - 1.
PB  - Springer
CY  - Cham
SN  - 9783030312602
KW  - Regenerative Medicine Tissue Engineering Biomimetic Composites Nanomaterials for Biomedicine Biocompatible Nanomaterials Engineering of Materials for Biocompatibility Nanostructures for Repair Heart Tissue Regeneration
UR  - https://link.springer.com/chapter/10.1007/978-3-030-31261-9_9
N2  - Cardiovascular disease is a leading cause of worldwide mortality. Despite the success of current therapies for acute myocardial infarction (MI), many patients still suffer irreversible damage, and the prevalence of heart failure is growing. After MI, the extracellular matrix (ECM) of the damaged myocardium is modified to produce scar tissue. This remodeling reduces the efficacy of therapies and also hinders endogenous repair mechanisms. Therefore, a strategy to prevent adverse remodeling and provide a suitable ECM environment that supports cells, tissue repair and functional restoration may lead to a superior therapeutic outcome in MI patients. Bioengineered materials are an attractive approach for achieving this. Herein, we review current research on materials that can act as a biomimetic matrix for supporting cellular repair in the post-MI heart. We also examine how nanomaterials are being used to treat the damaged heart. Finally, we provide an overview of the breakthroughs and limitations of biomaterial therapies for cardiac repair.
ER  -

SEDLÁKOVÁ, Veronika, Marc RUEL and Erik SUURONEN. Therapeutic Use of Bioengineered Materials for Myocardial Infarction. In Alarcon E., Ahumada M. (eds.). \textit{Nanoengineering Materials for Biomedical Uses}. Cham: Springer, 2019, p.~161-193. 1. ISBN~978-3-030-31260-2. Available from: https://dx.doi.org/10.1007/978-3-030-31261-9\_{}9.

Detailed Information on Publication Record