J 2020

AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

CALUORI, Guido, Eva ODEHNALOVÁ, Tomasz JADCZYK, Martin PEŠL, Iveta PAVLOVÁ et. al.

Basic information

Original name

AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

Authors

CALUORI, Guido (250 France), Eva ODEHNALOVÁ (203 Czech Republic), Tomasz JADCZYK (616 Poland), Martin PEŠL (203 Czech Republic, belonging to the institution), Iveta PAVLOVÁ (203 Czech Republic), Lucia VALÍKOVÁ (703 Slovakia), Steffen HOLZINGER (276 Germany), Veronika NOVOTNÁ (203 Czech Republic), Vladimír ROTREKL (203 Czech Republic, belonging to the institution), Aleš HAMPL (203 Czech Republic, belonging to the institution), Michal CRHA (203 Czech Republic), Dalibor ČERVINKA (203 Czech Republic) and Zdeněk STÁREK (203 Czech Republic, belonging to the institution)

Edition

Frontiers in bioengineering and biotechnology, Laussane, Frontiers Media S.A. 2020, 2296-4185

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10606 Microbiology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.890

RIV identification code

RIV/00216224:14110/20:00117252

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3389/fbioe.2020.552357

UT WoS

000599322800001

Keywords in English

pulsed field ablation; irreversible electroporation (IRE); radiofrequency ablation; atrial fibrillation; ventricular arrhythmia (VA); preclinical cardiology

Tags

14110115, 14110513, 14110517, CF CELLIM, rivok

Tags

International impact, Reviewed
Změněno: 10/10/2021 11:20, Mgr. Tereza Miškechová

Abstract

V originále

Pulsed field ablation (PFA) exploits the delivery of short high-voltage shocks to induce cells death via irreversible electroporation. The therapy offers a potential paradigm shift for catheter ablation of cardiac arrhythmia. We designed an AC-burst generator and therapeutic strategy, based on the existing knowledge between efficacy and safety among different pulses. We performed a proof-of-concept chronic animal trial to test the feasibility and safety of our method and technology.

Links

LM2015062, research and development project
Name: Národní infrastruktura pro biologické a medicínské zobrazování
Investor: Ministry of Education, Youth and Sports of the CR
Displayed: 11/11/2024 07:04