Individual differences in interoceptive accuracy and prediction
error in motor functional neurological disorders: A DTI study

J 2021

Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study

SOJKA, Petr, Ibai DIEZ, Martin BAREŠ and David L. PEREZ

Basic information

Original name

Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study

Authors

SOJKA, Petr (203 Czech Republic, guarantor, belonging to the institution), Ibai DIEZ, Martin BAREŠ (203 Czech Republic, belonging to the institution) and David L. PEREZ

Edition

Human Brain Mapping, Hoboken, Wiley, 2021, 1065-9471

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.399

RIV identification code

RIV/00216224:14110/21:00120078

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/hbm.25304

UT WoS

000596132200001

Keywords in English

conversion disorder; diffusion tensor imaging; dissociative seizures; DTI; functional movement disorder; interoception; psychogenic

Abstract

V originále

In motor functional neurological disorders (mFND), relationships between interoception (a construct of high theoretical relevance to its pathophysiology) and neuroanatomy have not been previously investigated. This study characterized white matter in mFND patients compared to healthy controls (HCs), and investigated associations between fiber bundle integrity and cardiac interoception. Voxel-based analysis and tractography quantified fractional anisotropy (FA) in 38 mFND patients compared to 38 HCs. Secondary analyses compared functional seizures (FND-seiz; n = 21) or functional movement disorders (n = 17) to HCs. Network lesion mapping identified gray matter origins of implicated fiber bundles. Within-group mFND analyses investigated relationships between FA, heartbeat tracking accuracy and interoceptive trait prediction error (discrepancies between interoceptive accuracy and self-reported bodily awareness). Results were corrected for multiple comparisons, and all findings were adjusted for depression and trait anxiety. mFND and HCs did not show any between-group interoceptive accuracy or FA differences. However, the FND-seiz subgroup compared to HCs showed decreased integrity in right-lateralized tracts: extreme capsule/inferior fronto-occipital fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, and thalamic/striatum to occipital cortex projections. These alterations originated predominantly from the right temporoparietal junction and inferior temporal gyrus. In mFND patients, individual differences in interoceptive accuracy and interoceptive trait prediction error correlated with fiber bundle integrity originating from the insula, temporoparietal junction, putamen and thalamus among other regions. In this first study investigating brain-interoception relationships in mFND, individual differences in interoceptive accuracy and trait prediction error mapped onto multimodal integration-related fiber bundles. Right-lateralized limbic and associative tract disruptions distinguished FND-seiz from HCs.

Links

NV16-31457A, research and development project

Name: Neurobiologické mechanismy funkčních neurologických poruch

Citovat

SOJKA, Petr, Ibai DIEZ, Martin BAREŠ and David L. PEREZ. Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study. Human Brain Mapping. Hoboken: Wiley, 2021, vol. 42, No 5, p. 1434-1445. ISSN 1065-9471. Available from: https://dx.doi.org/10.1002/hbm.25304.

@article{1705617,
   author = {Sojka, Petr and Diez, Ibai and Bareš, Martin and Perez, David L.},
   article_location = {Hoboken},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/hbm.25304},
   keywords = {conversion disorder; diffusion tensor imaging; dissociative seizures; DTI; functional movement disorder; interoception; psychogenic},
   language = {eng},
   issn = {1065-9471},
   journal = {Human Brain Mapping},
   title = {Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study},
   url = {https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25304},
   volume = {42},
   year = {2021}
}

TY  - JOUR
ID  - 1705617
AU  - Sojka, Petr - Diez, Ibai - Bareš, Martin - Perez, David L.
PY  - 2021
TI  - Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study
JF  - Human Brain Mapping
VL  - 42
IS  - 5
SP  - 1434-1445
EP  - 1434-1445
PB  - Wiley
SN  - 10659471
KW  - conversion disorder
KW  - diffusion tensor imaging
KW  - dissociative seizures
KW  - DTI
KW  - functional movement disorder
KW  - interoception
KW  - psychogenic
UR  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25304
L2  - https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hbm.25304
N2  - In motor functional neurological disorders (mFND), relationships between interoception (a construct of high theoretical relevance to its pathophysiology) and neuroanatomy have not been previously investigated. This study characterized white matter in mFND patients compared to healthy controls (HCs), and investigated associations between fiber bundle integrity and cardiac interoception. Voxel-based analysis and tractography quantified fractional anisotropy (FA) in 38 mFND patients compared to 38 HCs. Secondary analyses compared functional seizures (FND-seiz; n = 21) or functional movement disorders (n = 17) to HCs. Network lesion mapping identified gray matter origins of implicated fiber bundles. Within-group mFND analyses investigated relationships between FA, heartbeat tracking accuracy and interoceptive trait prediction error (discrepancies between interoceptive accuracy and self-reported bodily awareness). Results were corrected for multiple comparisons, and all findings were adjusted for depression and trait anxiety. mFND and HCs did not show any between-group interoceptive accuracy or FA differences. However, the FND-seiz subgroup compared to HCs showed decreased integrity in right-lateralized tracts: extreme capsule/inferior fronto-occipital fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, and thalamic/striatum to occipital cortex projections. These alterations originated predominantly from the right temporoparietal junction and inferior temporal gyrus. In mFND patients, individual differences in interoceptive accuracy and interoceptive trait prediction error correlated with fiber bundle integrity originating from the insula, temporoparietal junction, putamen and thalamus among other regions. In this first study investigating brain-interoception relationships in mFND, individual differences in interoceptive accuracy and trait prediction error mapped onto multimodal integration-related fiber bundles. Right-lateralized limbic and associative tract disruptions distinguished FND-seiz from HCs.
ER  -

SOJKA, Petr, Ibai DIEZ, Martin BAREŠ and David L. PEREZ. Individual differences in interoceptive accuracy and prediction error in motor functional neurological disorders: A DTI study. \textit{Human Brain Mapping}. Hoboken: Wiley, 2021, vol.~42, No~5, p.~1434-1445. ISSN~1065-9471. Available from: https://dx.doi.org/10.1002/hbm.25304.

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