Gas aggregated Ag NPs as a matrix for small molecules: a study
on natural amino acids

PRYSIAZHNYI, Vadym, Filip DYČKA, Jiri KRATOCHVIL and Vitezslav STRANAK. Gas aggregated Ag NPs as a matrix for small molecules: a study on natural amino acids. Journal of Nanoparticle Research. Dordrecht: Springer, 2020, vol. 22, No 11, p. 1-13. ISSN 1388-0764. Available from: https://dx.doi.org/10.1007/s11051-020-05082-4.

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TY  - JOUR
ID  - 1706076
AU  - Prysiazhnyi, Vadym - Dyčka, Filip - Kratochvil, Jiri - Stranak, Vitezslav
PY  - 2020
TI  - Gas aggregated Ag NPs as a matrix for small molecules: a study on natural amino acids
JF  - Journal of Nanoparticle Research
VL  - 22
IS  - 11
SP  - 1-13
EP  - 1-13
PB  - Springer
SN  - 13880764
KW  - Amino acids
KW  - Ag NPs
KW  - Gas aggregation source
KW  - Nano-PALDI MS
KW  - Nanomaterials
UR  - https://doi.org/10.1007/s11051-020-05082-4
L2  - https://doi.org/10.1007/s11051-020-05082-4
N2  - The use of nanomaterials as a matrix for soft ionization mass spectrometry has been investigated and reported various times. Under certain conditions, measurements of samples containing small molecules enhanced by nanomaterials have better sensitivity compared with other methods. Nanoscaled Ag prepared by various methods was reported as a substrate for surface-assisted LDI MS. Higher desorption and (in some cases) charge transfer through adduct formation with silver ion was reported. But primary ionization mechanism was through attachment of proton or alkali ion. Our approach is to overcoat the sample by Ag nanoparticles (the so-called nanoparticle-assisted LDI MS or nanoPALDI MS). As nanoparticles having adsorption maxima close to the laser wavelength, we expect an improvement in desorption enhancement, release of silver ions and (as a result of latter) increased adduct formation of [analyte+Ag](+) ions. The nanoparticles are produced by gas aggregation under low-pressure, making the process homogeneous over relatively large areas, free from impurities, and absence of capping agent often presented in colloidal nanoparticles. This work reports the detection of natural amino acids with Ag nanoparticles as a matrix. We successfully detected all amino acids (as [analyte+Ag](+) ion), including in the mixtures of few amino acids. Moreover, a formation of other adducts, particularly [analyte+Ag-3](+) and [analyte(2)+Ag](+) is reported. The differences in ion intensity ratios depending on amino acid types are discussed. The obtained results showed that laser ablation is more efficient for amino acids with hydrophobic, unique, and neutral side chains.
ER  -

Basic information
Original name	Gas aggregated Ag NPs as a matrix for small molecules: a study on natural amino acids
Authors	PRYSIAZHNYI, Vadym (804 Ukraine, guarantor, belonging to the institution), Filip DYČKA (203 Czech Republic), Jiri KRATOCHVIL and Vitezslav STRANAK.
Edition	Journal of Nanoparticle Research, Dordrecht, Springer, 2020, 1388-0764.

Other information
Original language	English
Type of outcome	Article in a journal
Field of Study	10406 Analytical chemistry
Country of publisher	Netherlands
Confidentiality degree	is not subject to a state or trade secret
WWW	URL
Impact factor	Impact factor: 2.253
RIV identification code	RIV/00216224:14310/20:00114556
Organization unit	Faculty of Science
Doi	http://dx.doi.org/10.1007/s11051-020-05082-4
UT WoS	000590492200001
Keywords in English	Amino acids; Ag NPs; Gas aggregation source; Nano-PALDI MS; Nanomaterials
Tags	rivok
Tags	International impact, Reviewed
Changed by	Changed by: Mgr. Vadym Prysiazhnyi, Ph.D., učo 344791. Changed: 17/12/2020 13:29.

Abstract

The use of nanomaterials as a matrix for soft ionization mass spectrometry has been investigated and reported various times. Under certain conditions, measurements of samples containing small molecules enhanced by nanomaterials have better sensitivity compared with other methods. Nanoscaled Ag prepared by various methods was reported as a substrate for surface-assisted LDI MS. Higher desorption and (in some cases) charge transfer through adduct formation with silver ion was reported. But primary ionization mechanism was through attachment of proton or alkali ion. Our approach is to overcoat the sample by Ag nanoparticles (the so-called nanoparticle-assisted LDI MS or nanoPALDI MS). As nanoparticles having adsorption maxima close to the laser wavelength, we expect an improvement in desorption enhancement, release of silver ions and (as a result of latter) increased adduct formation of [analyte+Ag](+) ions. The nanoparticles are produced by gas aggregation under low-pressure, making the process homogeneous over relatively large areas, free from impurities, and absence of capping agent often presented in colloidal nanoparticles. This work reports the detection of natural amino acids with Ag nanoparticles as a matrix. We successfully detected all amino acids (as [analyte+Ag](+) ion), including in the mixtures of few amino acids. Moreover, a formation of other adducts, particularly [analyte+Ag-3](+) and [analyte(2)+Ag](+) is reported. The differences in ion intensity ratios depending on amino acid types are discussed. The obtained results showed that laser ablation is more efficient for amino acids with hydrophobic, unique, and neutral side chains.

Links
GJ19-20927Y, research and development project	Name: MALDI MS zobrazování izomerů lipidů lišících se pozicí dvojné vazby uhlík-uhlík
GJ19-20927Y, research and development project	Investor: Czech Science Foundation

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Gas aggregated Ag NPs as a matrix for small molecules: a study on natural amino acids

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