Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers

KINCL, Vladimír, Roman PANOVSKÝ, Martin PEŠL, Jan MÁCHAL, Lenka JUŘÍKOVÁ, Jana HABERLOVÁ and Lucia MASÁROVÁ. Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers. Scientific Reports. Berlin: Nature, 2020, vol. 10, No 1, p. 1-6. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-77882-6.

Basic information

• Original name: Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers
• Authors: KINCL, Vladimír (203 Czech Republic, guarantor, belonging to the institution), Roman PANOVSKÝ (203 Czech Republic, belonging to the institution), Martin PEŠL (203 Czech Republic, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Lenka JUŘÍKOVÁ (203 Czech Republic, belonging to the institution), Jana HABERLOVÁ (203 Czech Republic) and Lucia MASÁROVÁ (703 Slovakia, belonging to the institution).
• Edition: Scientific Reports, Berlin, Nature, 2020, 2045-2322.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30201 Cardiac and Cardiovascular systems
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.379
• RIV identification code: RIV/00216224:14110/20:00117280
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1038/s41598-020-77882-6
• UT WoS: 000596311900004
• Keywords in English: Duchenne dystrophy; subclinical cardiac function impairment
• Tags: 14110115, 14110320, 14110513, 14110518, rivok
• Tags: International impact, Reviewed

Abstract

To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p<0.001, 0.08 vs. 0.09 m/s, p<0.01 and 0.13 vs. 0.14 m/s, p=0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p=0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.

Links

• MUNI/A/1493/2018, interní kód MU: Name: Hodnocení funkce levé komory s využitím metody feature tracking u nosiček genů pro Duchennovu muskulární dystrofii (Acronym: CMRDMD)

Investor: Masaryk University, Category A