Echocardiographic signs of subclinical cardiac function
impairment in Duchenne dystrophy gene carriers

J 2020

Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers

KINCL, Vladimír, Roman PANOVSKÝ, Martin PEŠL, Jan MÁCHAL, Lenka JUŘÍKOVÁ et. al.

Basic information

Original name

Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers

Authors

KINCL, Vladimír (203 Czech Republic, guarantor, belonging to the institution), Roman PANOVSKÝ (203 Czech Republic, belonging to the institution), Martin PEŠL (203 Czech Republic, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Lenka JUŘÍKOVÁ (203 Czech Republic, belonging to the institution), Jana HABERLOVÁ (203 Czech Republic) and Lucia MASÁROVÁ (703 Slovakia, belonging to the institution)

Edition

Scientific Reports, Berlin, Nature, 2020, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.379

RIV identification code

RIV/00216224:14110/20:00117280

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-020-77882-6

UT WoS

000596311900004

Keywords in English

Duchenne dystrophy; subclinical cardiac function impairment

Abstract

V originále

To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p<0.001, 0.08 vs. 0.09 m/s, p<0.01 and 0.13 vs. 0.14 m/s, p=0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p=0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.

Links

MUNI/A/1493/2018, interní kód MU

Name: Hodnocení funkce levé komory s využitím metody feature tracking u nosiček genů pro Duchennovu muskulární dystrofii (Acronym: CMRDMD)

Investor: Masaryk University, Category A

Citovat

KINCL, Vladimír, Roman PANOVSKÝ, Martin PEŠL, Jan MÁCHAL, Lenka JUŘÍKOVÁ, Jana HABERLOVÁ and Lucia MASÁROVÁ. Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers. Scientific Reports. Berlin: Nature, 2020, vol. 10, No 1, p. 1-6. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-77882-6.

@article{1706276,
   author = {Kincl, Vladimír and Panovský, Roman and Pešl, Martin and Máchal, Jan and Juříková, Lenka and Haberlová, Jana and Masárová, Lucia},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-020-77882-6},
   keywords = {Duchenne dystrophy; subclinical cardiac function impairment},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers},
   url = {https://www.nature.com/articles/s41598-020-77882-6.pdf},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1706276
AU  - Kincl, Vladimír - Panovský, Roman - Pešl, Martin - Máchal, Jan - Juříková, Lenka - Haberlová, Jana - Masárová, Lucia
PY  - 2020
TI  - Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers
JF  - Scientific Reports
VL  - 10
IS  - 1
SP  - 1-6
EP  - 1-6
PB  - Nature
SN  - 20452322
KW  - Duchenne dystrophy
KW  - subclinical cardiac function impairment
UR  - https://www.nature.com/articles/s41598-020-77882-6.pdf
L2  - https://www.nature.com/articles/s41598-020-77882-6.pdf
N2  - To assess subclinical cardiac function impairment in Duchenne dystrophy (DMD) female carriers. Forty-four female subjects proved as DMD carriers underwent echocardiographic examination including tissue Doppler imaging (TDI) of mitral and tricuspid annulus. Seventeen age-matched healthy female subjects served as controls. A significant differences in peak systolic annular velocity (Sa) between carriers and controls were found for lateral and septal part of the mitral annulus and for tricuspid annulus (0.09 vs. 0.11 m/s, p<0.001, 0.08 vs. 0.09 m/s, p<0.01 and 0.13 vs. 0.14 m/s, p=0.02 respectively). There was also difference in early diastolic velocity (Ea) of the septal part of the mitral annulus (0.11 vs. 0.13 m/s, p=0.03). The subclinical deterioration of systolic function is presented even in asymptomatic DMD female carriers.
ER  -

KINCL, Vladimír, Roman PANOVSKÝ, Martin PEŠL, Jan MÁCHAL, Lenka JUŘÍKOVÁ, Jana HABERLOVÁ and Lucia MASÁROVÁ. Echocardiographic signs of subclinical cardiac function impairment in Duchenne dystrophy gene carriers. \textit{Scientific Reports}. Berlin: Nature, 2020, vol.~10, No~1, p.~1-6. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-77882-6.

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