Temporally and sex-specific effects of maternal perinatal
stress on offspring cortical gyrification and mood in young
adulthood

J 2020

Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

MAREČKOVÁ, Klára, Amy MILES, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, Yuliya S. NIKOLOVA et. al.

Basic information

Original name

Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

Authors

MAREČKOVÁ, Klára (203 Czech Republic, guarantor, belonging to the institution), Amy MILES, Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Yuliya S. NIKOLOVA

Edition

Human Brain mapping, Hoboken, Wiley, 2020, 1065-9471

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.038

RIV identification code

RIV/00216224:14740/20:00117301

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1002/hbm.25163

UT WoS

000574703300001

Keywords in English

dysregulated mood; gyrification; magnetic resonance imaging; perinatal stress; prenatal birth cohort; sex; young adulthood

Abstract

V originále

Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f(2)= 0.19-0.38,p< .001), later perinatal stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f(2)= 0.10-0.19,p< .003). Moreover, in females, early prenatal stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r= 0.399,p= .006). These findings point out the long-term implications of perinatal stress exposure for cortical morphology and mood dysregulation.

Links

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

90062, large research infrastructures

Name: Czech-BioImaging

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

MAREČKOVÁ, Klára, Amy MILES, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Yuliya S. NIKOLOVA. Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood. Human Brain mapping. Hoboken: Wiley, 2020, vol. 41, No 17, p. 4866-4875. ISSN 1065-9471. Available from: https://dx.doi.org/10.1002/hbm.25163.

@article{1706897,
   author = {Marečková, Klára and Miles, Amy and Andrýsková, Lenka and Brázdil, Milan and Nikolova, Yuliya S.},
   article_location = {Hoboken},
   article_number = {17},
   doi = {http://dx.doi.org/10.1002/hbm.25163},
   keywords = {dysregulated mood; gyrification; magnetic resonance imaging; perinatal stress; prenatal birth cohort; sex; young adulthood},
   language = {eng},
   issn = {1065-9471},
   journal = {Human Brain mapping},
   title = {Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood},
   url = {https://doi.org/10.1002/hbm.25163},
   volume = {41},
   year = {2020}
}

TY  - JOUR
ID  - 1706897
AU  - Marečková, Klára - Miles, Amy - Andrýsková, Lenka - Brázdil, Milan - Nikolova, Yuliya S.
PY  - 2020
TI  - Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood
JF  - Human Brain mapping
VL  - 41
IS  - 17
SP  - 4866-4875
EP  - 4866-4875
PB  - Wiley
SN  - 10659471
KW  - dysregulated mood
KW  - gyrification
KW  - magnetic resonance imaging
KW  - perinatal stress
KW  - prenatal birth cohort
KW  - sex
KW  - young adulthood
UR  - https://doi.org/10.1002/hbm.25163
L2  - https://doi.org/10.1002/hbm.25163
N2  - Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f(2)= 0.19-0.38,p< .001), later perinatal stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f(2)= 0.10-0.19,p< .003). Moreover, in females, early prenatal stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r= 0.399,p= .006). These findings point out the long-term implications of perinatal stress exposure for cortical morphology and mood dysregulation.
ER  -

MAREČKOVÁ, Klára, Amy MILES, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Yuliya S. NIKOLOVA. Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood. \textit{Human Brain mapping}. Hoboken: Wiley, 2020, vol.~41, No~17, p.~4866-4875. ISSN~1065-9471. Available from: https://dx.doi.org/10.1002/hbm.25163.

Detailed Information on Publication Record