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@article{1707000, author = {Kataja, Anu and Tarvasmäki, Tuukka and Lassus, Johan and Sionis, Alessandro and Mebazaa, Alexandre and Pulkki, Kari and Banaszewski, Marek and Carubelli, Valentina and Hongisto, Mari and Jankowska, Ewa and Jurkko, Raija and Jäntti, Toni and Kasztura, Monika and Parissis, John and Sabell, Tuija and SilvaandCardoso, Jose and Špinar, Jindřich and Tolppanen, Heli and Harjola, VeliandPekka}, article_location = {Clare}, article_number = {JAN 2021}, doi = {http://dx.doi.org/10.1016/j.ijcard.2020.08.069}, keywords = {Cardiogenic shock; Inflammation; Procalcitonin; Interleukin 6; C-reactive protein}, language = {eng}, issn = {0167-5273}, journal = {International Journal of Cardiology}, title = {Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study}, url = {https://www.internationaljournalofcardiology.com/article/S0167-5273(20)33652-4/abstract#%20}, volume = {322}, year = {2021} }
TY - JOUR ID - 1707000 AU - Kataja, Anu - Tarvasmäki, Tuukka - Lassus, Johan - Sionis, Alessandro - Mebazaa, Alexandre - Pulkki, Kari - Banaszewski, Marek - Carubelli, Valentina - Hongisto, Mari - Jankowska, Ewa - Jurkko, Raija - Jäntti, Toni - Kasztura, Monika - Parissis, John - Sabell, Tuija - Silva-Cardoso, Jose - Špinar, Jindřich - Tolppanen, Heli - Harjola, Veli-Pekka PY - 2021 TI - Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study JF - International Journal of Cardiology VL - 322 IS - JAN 2021 SP - 191-196 EP - 191-196 PB - Elsevier SN - 01675273 KW - Cardiogenic shock KW - Inflammation KW - Procalcitonin KW - Interleukin 6 KW - C-reactive protein UR - https://www.internationaljournalofcardiology.com/article/S0167-5273(20)33652-4/abstract#%20 L2 - https://www.internationaljournalofcardiology.com/article/S0167-5273(20)33652-4/abstract#%20 N2 - Background Inflammatory responses play an important role in the pathophysiology of cardiogenic shock (CS). The aim of this study was to investigate the kinetics of procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) in CS and to assess their relation to clinical presentation, other biochemical variables, and prognosis. Methods Levels of PCT, CRP and IL-6 were analyzed in serial plasma samples (0−120 h) from 183 patients in the CardShock study. The study population was dichotomized by PCT max ≥ and < 0.5 μg/L, and IL-6 and CRP max above/below median. Results PCT peaked already at 24 h [median PCT max 0.71 μg/L (IQR 0.24–3.4)], whereas CRP peaked later between 48 and 72 h [median CRP max 137 mg/L (59–247)]. PCT levels were significantly higher among non-survivors compared with survivors from 12 h on, as were CRP levels from 24 h on ( p < 0.001). PCT max ≥ 0.5 μg/L (60% of patients) was associated with clinical signs of systemic hypoperfusion, cardiac and renal dysfunction, acidosis, and higher levels of blood lactate, IL-6, growth-differentiation factor 15 (GDF-15), and CRP max. Similarly, IL-6 > median was associated with clinical signs and biochemical findings of systemic hypoperfusion. PCT max ≥ 0.5 μg/L and IL-6 > median were associated with increased 90-day mortality (50% vs. 30% and 57% vs. 22%, respectively; p < 0.01 for both), while CRP max showed no prognostic significance. The association of inflammatory markers with clinical infections was modest. Conclusions Inflammatory markers are highly related to signs of systemic hypoperfusion in CS. Moreover, high PCT and IL-6 levels are associated with poor prognosis. ER -
KATAJA, Anu, Tuukka TARVASMÄKI, Johan LASSUS, Alessandro SIONIS, Alexandre MEBAZAA, Kari PULKKI, Marek BANASZEWSKI, Valentina CARUBELLI, Mari HONGISTO, Ewa JANKOWSKA, Raija JURKKO, Toni JÄNTTI, Monika KASZTURA, John PARISSIS, Tuija SABELL, Jose SILVA-CARDOSO, Jindřich ŠPINAR, Heli TOLPPANEN and Veli-Pekka HARJOLA. Kinetics of procalcitonin, C-reactive protein and interleukin-6 in cardiogenic shock – Insights from the CardShock study. \textit{International Journal of Cardiology}. Clare: Elsevier, 2021, vol.~322, JAN 2021, p.~191-196. ISSN~0167-5273. Available from: https://dx.doi.org/10.1016/j.ijcard.2020.08.069.
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