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@article{1707540,
author = {Dosedělová, Věra and Itterheimová, Petra and Kubáň, Petr},
article_location = {Hoboken},
article_number = {1-2},
doi = {http://dx.doi.org/10.1002/elps.202000139},
keywords = {Bile acids; Clinical analysis; GC-MS; HPLC-MS; Microcolumn separation},
language = {eng},
issn = {0173-0835},
journal = {Electrophoresis},
title = {Analysis of bile acids in human biological samples by microcolumn separation techniques: A review},
url = {https://doi.org/10.1002/elps.202000139},
volume = {42},
year = {2021}
}
TY - JOUR
ID - 1707540
AU - Dosedělová, Věra - Itterheimová, Petra - Kubáň, Petr
PY - 2021
TI - Analysis of bile acids in human biological samples by microcolumn separation techniques: A review
JF - Electrophoresis
VL - 42
IS - 1-2
SP - 68-85
EP - 68-85
PB - Wiley
SN - 01730835
KW - Bile acids
KW - Clinical analysis
KW - GC-MS
KW - HPLC-MS
KW - Microcolumn separation
UR - https://doi.org/10.1002/elps.202000139
L2 - https://doi.org/10.1002/elps.202000139
N2 - Bile acids are a group of compounds essential for lipid digestion and absorption with a steroid skeleton and a carboxylate side chain usually conjugated to glycine or taurine. Bile acids are regulatory molecules for a number of metabolic processes and can be used as biomarkers of various disorders. Since the middle of the twentieth century, the detection of bile acids has evolved from simple qualitative analysis to accurate quantification in complicated mixtures. Advanced methods are required to characterize and quantify individual bile acids in these mixtures. This article overviews the literature from the last two decades (2000-2020) and focuses on bile acid analysis in various human biological samples. The methods for sample preparation, including the sample treatment of conventional (blood plasma, blood serum, and urine) and unconventional samples (bile, saliva, duodenal/gastric juice, feces, etc.) are shortly discussed. Eventually, the focus is on novel analytical approaches and methods for each particular biological sample, providing an overview of the microcolumn separation techniques, such as high-performance liquid chromatography, gas chromatography, and capillary electrophoresis, used in their analysis. This is followed by a discussion on selected clinical applications.
ER -
DOSEDĚLOVÁ, Věra, Petra ITTERHEIMOVÁ and Petr KUBÁŇ. Analysis of bile acids in human biological samples by microcolumn separation techniques: A review. \textit{Electrophoresis}. Hoboken: Wiley, 2021, vol.~42, 1-2, p.~68-85. ISSN~0173-0835. Available from: https://dx.doi.org/10.1002/elps.202000139.
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