J 2021

Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease

DI BARTOLOMEO, Martina, Tibor ŠTARK, Maurel ORIANA MARIA, Fabio Arturo IANNOTTI, Martin KUCHAR et. al.

Basic information

Original name

Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease

Name in Czech

Vztah mezi regulací trankripce D2 a CB1 receptorů v perimatálním delta9-tetrahydrocannabinolovém modelu a u pacientů se schizofrenií

Authors

DI BARTOLOMEO, Martina (380 Italy), Tibor ŠTARK (703 Slovakia, belonging to the institution), Maurel ORIANA MARIA (380 Italy), Fabio Arturo IANNOTTI (380 Italy), Martin KUCHAR (203 Czech Republic), Jana RUDÁ (203 Czech Republic, belonging to the institution), Fabiana PISCITELLI (380 Italy), Samuele LAUDANI (380 Italy), Vladimír PEKAŘÍK (203 Czech Republic, belonging to the institution), Salvatore SALOMONE (124 Canada), Beatrice AROSIO (380 Italy), Raphael MECHOULAM, Mauro MACCARRONE (380 Italy), Filippo DRAGO (380 Italy), Carsten WOTJAK (276 Germany), Vincenzo DI MARZO (380 Italy), Matteo VISMARA (380 Italy), Bernardo DELL'OSSO (380 Italy), Claudio D'ADDARIO (380 Italy) and Vincenzo MICALE (380 Italy, guarantor)

Edition

PHARMACOLOGICAL RESEARCH, London, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, 1043-6618

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 10.334

RIV identification code

RIV/00216224:14110/21:00120866

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.phrs.2020.105357

UT WoS

000615153300017

Keywords in English

Schizophrenia; THC; Cannabinoid CB1 receptor; Dopamine D2 Receptor; Cannabidiol; DNA methylation; Epigenetics

Tags

14110515, 14110516, rivok

Tags

International impact, Reviewed
Změněno: 15/6/2021 08:01, Mgr. Tereza Miškechová

Abstract

V originále

Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.

Links

MUNI/A/1292/2019, interní kód MU
Name: Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii
Investor: Masaryk University, Category A
Displayed: 3/11/2024 12:17