DI BARTOLOMEO, Martina, Tibor ŠTARK, Maurel ORIANA MARIA, Fabio Arturo IANNOTTI, Martin KUCHAR, Jana RUDÁ, Fabiana PISCITELLI, Samuele LAUDANI, Vladimír PEKAŘÍK, Salvatore SALOMONE, Beatrice AROSIO, Raphael MECHOULAM, Mauro MACCARRONE, Filippo DRAGO, Carsten WOTJAK, Vincenzo DI MARZO, Matteo VISMARA, Bernardo DELL'OSSO, Claudio D'ADDARIO and Vincenzo MICALE. Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease. PHARMACOLOGICAL RESEARCH. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, vol. 164, FEB 2021, p. 105357-105366. ISSN 1043-6618. Available from: https://dx.doi.org/10.1016/j.phrs.2020.105357.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease
Name in Czech Vztah mezi regulací trankripce D2 a CB1 receptorů v perimatálním delta9-tetrahydrocannabinolovém modelu a u pacientů se schizofrenií
Authors DI BARTOLOMEO, Martina (380 Italy), Tibor ŠTARK (703 Slovakia, belonging to the institution), Maurel ORIANA MARIA (380 Italy), Fabio Arturo IANNOTTI (380 Italy), Martin KUCHAR (203 Czech Republic), Jana RUDÁ (203 Czech Republic, belonging to the institution), Fabiana PISCITELLI (380 Italy), Samuele LAUDANI (380 Italy), Vladimír PEKAŘÍK (203 Czech Republic, belonging to the institution), Salvatore SALOMONE (124 Canada), Beatrice AROSIO (380 Italy), Raphael MECHOULAM, Mauro MACCARRONE (380 Italy), Filippo DRAGO (380 Italy), Carsten WOTJAK (276 Germany), Vincenzo DI MARZO (380 Italy), Matteo VISMARA (380 Italy), Bernardo DELL'OSSO (380 Italy), Claudio D'ADDARIO (380 Italy) and Vincenzo MICALE (380 Italy, guarantor).
Edition PHARMACOLOGICAL RESEARCH, London, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, 1043-6618.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 10.334
RIV identification code RIV/00216224:14110/21:00120866
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.phrs.2020.105357
UT WoS 000615153300017
Keywords in English Schizophrenia; THC; Cannabinoid CB1 receptor; Dopamine D2 Receptor; Cannabidiol; DNA methylation; Epigenetics
Tags 14110515, 14110516, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 15/6/2021 08:01.
Abstract
Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.
Links
MUNI/A/1292/2019, interní kód MUName: Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii
Investor: Masaryk University, Category A
PrintDisplayed: 15/7/2024 21:32