Crosstalk between the transcriptional regulation of dopamine D2
and cannabinoid CB1 receptors in perinatal
delta9-tetrahydrocannabinol occurs in schizophrenia: analyses
in patients and in animal model of the disease

J 2021

Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease

DI BARTOLOMEO, Martina, Tibor ŠTARK, Maurel ORIANA MARIA, Fabio Arturo IANNOTTI, Martin KUCHAR et. al.

Basic information

Original name

Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease

Name in Czech

Vztah mezi regulací trankripce D2 a CB1 receptorů v perimatálním delta9-tetrahydrocannabinolovém modelu a u pacientů se schizofrenií

Authors

DI BARTOLOMEO, Martina (380 Italy), Tibor ŠTARK (703 Slovakia, belonging to the institution), Maurel ORIANA MARIA (380 Italy), Fabio Arturo IANNOTTI (380 Italy), Martin KUCHAR (203 Czech Republic), Jana RUDÁ (203 Czech Republic, belonging to the institution), Fabiana PISCITELLI (380 Italy), Samuele LAUDANI (380 Italy), Vladimír PEKAŘÍK (203 Czech Republic, belonging to the institution), Salvatore SALOMONE (124 Canada), Beatrice AROSIO (380 Italy), Raphael MECHOULAM, Mauro MACCARRONE (380 Italy), Filippo DRAGO (380 Italy), Carsten WOTJAK (276 Germany), Vincenzo DI MARZO (380 Italy), Matteo VISMARA (380 Italy), Bernardo DELL'OSSO (380 Italy), Claudio D'ADDARIO (380 Italy) and Vincenzo MICALE (380 Italy, guarantor)

Edition

PHARMACOLOGICAL RESEARCH, London, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, 1043-6618

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 10.334

RIV identification code

RIV/00216224:14110/21:00120866

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.phrs.2020.105357

UT WoS

000615153300017

Keywords in English

Schizophrenia; THC; Cannabinoid CB1 receptor; Dopamine D2 Receptor; Cannabidiol; DNA methylation; Epigenetics

Abstract

V originále

Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.

Links

MUNI/A/1292/2019, interní kód MU

Name: Preklinický a klinický výzkum studentů v oblasti farmakokinetiky, neuropsychofarmakologie a personalizované farmakoterapie v onkologii

Investor: Masaryk University, Category A

Citovat

DI BARTOLOMEO, Martina, Tibor ŠTARK, Maurel ORIANA MARIA, Fabio Arturo IANNOTTI, Martin KUCHAR, Jana RUDÁ, Fabiana PISCITELLI, Samuele LAUDANI, Vladimír PEKAŘÍK, Salvatore SALOMONE, Beatrice AROSIO, Raphael MECHOULAM, Mauro MACCARRONE, Filippo DRAGO, Carsten WOTJAK, Vincenzo DI MARZO, Matteo VISMARA, Bernardo DELL'OSSO, Claudio D'ADDARIO and Vincenzo MICALE. Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease. PHARMACOLOGICAL RESEARCH. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, vol. 164, FEB 2021, p. 105357-105366. ISSN 1043-6618. Available from: https://dx.doi.org/10.1016/j.phrs.2020.105357.

@article{1709396,
   author = {Di Bartolomeo, Martina and Štark, Tibor and Oriana Maria, Maurel and Iannotti, Fabio Arturo and Kuchar, Martin and Rudá, Jana and Piscitelli, Fabiana and Laudani, Samuele and Pekařík, Vladimír and Salomone, Salvatore and Arosio, Beatrice and Mechoulam, Raphael and Maccarrone, Mauro and Drago, Filippo and Wotjak, Carsten and Di Marzo, Vincenzo and Vismara, Matteo and Dell'Osso, Bernardo and D'Addario, Claudio and Micale, Vincenzo},
   article_location = {London},
   article_number = {FEB 2021},
   doi = {http://dx.doi.org/10.1016/j.phrs.2020.105357},
   keywords = {Schizophrenia; THC; Cannabinoid CB1 receptor; Dopamine D2 Receptor; Cannabidiol; DNA methylation; Epigenetics},
   language = {eng},
   issn = {1043-6618},
   journal = {PHARMACOLOGICAL RESEARCH},
   title = {Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease},
   url = {https://www.sciencedirect.com/science/article/pii/S1043661820316650?via%3Dihub},
   volume = {164},
   year = {2021}
}

TY  - JOUR
ID  - 1709396
AU  - Di Bartolomeo, Martina - Štark, Tibor - Oriana Maria, Maurel - Iannotti, Fabio Arturo - Kuchar, Martin - Rudá, Jana - Piscitelli, Fabiana - Laudani, Samuele - Pekařík, Vladimír - Salomone, Salvatore - Arosio, Beatrice - Mechoulam, Raphael - Maccarrone, Mauro - Drago, Filippo - Wotjak, Carsten - Di Marzo, Vincenzo - Vismara, Matteo - Dell'Osso, Bernardo - D'Addario, Claudio - Micale, Vincenzo
PY  - 2021
TI  - Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease
JF  - PHARMACOLOGICAL RESEARCH
VL  - 164
IS  - FEB 2021
SP  - 105357
EP  - 105357
PB  - ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
SN  - 10436618
KW  - Schizophrenia
KW  - THC
KW  - Cannabinoid CB1 receptor
KW  - Dopamine D2 Receptor
KW  - Cannabidiol
KW  - DNA methylation
KW  - Epigenetics
UR  - https://www.sciencedirect.com/science/article/pii/S1043661820316650?via%3Dihub
N2  - Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.
ER  -

DI BARTOLOMEO, Martina, Tibor ŠTARK, Maurel ORIANA MARIA, Fabio Arturo IANNOTTI, Martin KUCHAR, Jana RUDÁ, Fabiana PISCITELLI, Samuele LAUDANI, Vladimír PEKAŘÍK, Salvatore SALOMONE, Beatrice AROSIO, Raphael MECHOULAM, Mauro MACCARRONE, Filippo DRAGO, Carsten WOTJAK, Vincenzo DI MARZO, Matteo VISMARA, Bernardo DELL'OSSO, Claudio D'ADDARIO and Vincenzo MICALE. Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease. \textit{PHARMACOLOGICAL RESEARCH}. London: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2021, vol.~164, FEB 2021, p.~105357-105366. ISSN~1043-6618. Available from: https://dx.doi.org/10.1016/j.phrs.2020.105357.

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