Chiral conazole fungicides - (Enantioselective) terrestrial
bioaccumulation and aquatic toxicity

J 2020

Chiral conazole fungicides - (Enantioselective) terrestrial bioaccumulation and aquatic toxicity

ŠKULCOVÁ, Lucia, Naveen NJATTUVETTY CHANDRAN and Lucie BIELSKÁ

Basic information

Original name

Chiral conazole fungicides - (Enantioselective) terrestrial bioaccumulation and aquatic toxicity

Authors

ŠKULCOVÁ, Lucia (703 Slovakia, belonging to the institution), Naveen NJATTUVETTY CHANDRAN (356 India, belonging to the institution) and Lucie BIELSKÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Science of the Total Environment, Amsterdam, Elsevier Science, 2020, 0048-9697

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10511 Environmental sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 7.963

RIV identification code

RIV/00216224:14310/20:00117361

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1016/j.scitotenv.2020.140821

UT WoS

000573543300017

Keywords in English

Conazole fungicides; Nematodes; Chironomids; Earthworms; bioaccumualation; Multigeneration exposure

Abstract

V originále

Five conazole fungicides (CFs) (epoxiconazole, tebuconazole, myclobutanil, uniconazole (P), rac-uniconazole, and diniconazole) were tested in order to provide additional information on i) the effects of CFs on the nematode Caenorhabditis elegans and on the aquatic insect Chironomus riparius under acute exposure scenarios and in multi-generation exposure studies, taking advantage of the short life cycle of nematodes and ii) on the bioaccumulation (earthworm Elsenia andrei) profiles of CFs including also the enantiomer-specific assessment of degradation in soils and uptake/elimination by earthworms. Acute toxicity was considered low following the exposure of up to 2.5 mg of CFs per liter of the test medium. In a multigeneration study on nematodes, all five generations exposed to epoxiconazole were significantly negatively affected in terms of reproductive efficiency, and the severity of effects increased from F0 to F1 generation and was sustained thereafter. Adverse effects were also observed in the case of uniconazole (P) and diniconazole, and similarly to epoxiconazole, the effects occurred within the active life of the pesticides and were assumed to be based on their half-lives in soil (e.g., 53.3 to 691 days for uniconazole and diniconazole in our study) and in sediment/water. Bioaccumulation of diniconazole and uniconazole by earthworms varied between soils (Lufa 2.1 >= Lufa 2.4 > sandy soil > Lufa 2.2) and compounds (diniconazole > uniconazole) and was enantioselective. Earthworms preferentially accumulated R-uniconazole as a result of faster elimination of the S-form, which was evidenced from the enantiomer-specific uptake/elimination rate constants derived from the bioaccumulation profiles. Our results suggest that multigeneration exposure studies can advantageously be used for assessing the long-term and trans-general effects of pesticides. Also, the enantioselectivity in bioaccumulation observed for both uniconazole and diniconazole suggests that enantioselectivity in the fate and effects should be considered when exploring ways for safer and sustainable use of chiral pesticides.

Links

EF17_043/0009632, research and development project

Name: CETOCOEN Excellence

GJ18-14926Y, research and development project

Name: Enanatioselectivita současných chirálních conazolových fungicidů

LM2018121, research and development project

Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

Citovat

ŠKULCOVÁ, Lucia, Naveen NJATTUVETTY CHANDRAN and Lucie BIELSKÁ. Chiral conazole fungicides - (Enantioselective) terrestrial bioaccumulation and aquatic toxicity. Science of the Total Environment. Amsterdam: Elsevier Science, 2020, vol. 743, November 2020, p. 1-12. ISSN 0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2020.140821.

@article{1709822,
   author = {Škulcová, Lucia and Njattuvetty Chandran, Naveen and Bielská, Lucie},
   article_location = {Amsterdam},
   article_number = {November 2020},
   doi = {http://dx.doi.org/10.1016/j.scitotenv.2020.140821},
   keywords = {Conazole fungicides; Nematodes; Chironomids; Earthworms; bioaccumualation; Multigeneration exposure},
   language = {eng},
   issn = {0048-9697},
   journal = {Science of the Total Environment},
   note = {CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.},
   title = {Chiral conazole fungicides - (Enantioselective) terrestrial bioaccumulation and aquatic toxicity},
   url = {https://www.sciencedirect.com/science/article/pii/S004896972034345X?via%3Dihub},
   volume = {743},
   year = {2020}
}

TY  - JOUR
ID  - 1709822
AU  - Škulcová, Lucia - Njattuvetty Chandran, Naveen - Bielská, Lucie
PY  - 2020
TI  - Chiral conazole fungicides - (Enantioselective) terrestrial bioaccumulation and aquatic toxicity
JF  - Science of the Total Environment
VL  - 743
IS  - November 2020
SP  - 1-12
EP  - 1-12
PB  - Elsevier Science
SN  - 00489697
N1  - CZ.02.1.01/0.0/0.0/18_046/0015975 neuplatňovat.
KW  - Conazole fungicides
KW  - Nematodes
KW  - Chironomids
KW  - Earthworms
KW  - bioaccumualation
KW  - Multigeneration exposure
UR  - https://www.sciencedirect.com/science/article/pii/S004896972034345X?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/pii/S004896972034345X?via%3Dihub
N2  - Five conazole fungicides (CFs) (epoxiconazole, tebuconazole, myclobutanil, uniconazole (P), rac-uniconazole, and diniconazole) were tested in order to provide additional information on i) the effects of CFs on the nematode Caenorhabditis elegans and on the aquatic insect Chironomus riparius under acute exposure scenarios and in multi-generation exposure studies, taking advantage of the short life cycle of nematodes and ii) on the bioaccumulation (earthworm Elsenia andrei) profiles of CFs including also the enantiomer-specific assessment of degradation in soils and uptake/elimination by earthworms. Acute toxicity was considered low following the exposure of up to 2.5 mg of CFs per liter of the test medium. In a multigeneration study on nematodes, all five generations exposed to epoxiconazole were significantly negatively affected in terms of reproductive efficiency, and the severity of effects increased from F0 to F1 generation and was sustained thereafter. Adverse effects were also observed in the case of uniconazole (P) and diniconazole, and similarly to epoxiconazole, the effects occurred within the active life of the pesticides and were assumed to be based on their half-lives in soil (e.g., 53.3 to 691 days for uniconazole and diniconazole in our study) and in sediment/water. Bioaccumulation of diniconazole and uniconazole by earthworms varied between soils (Lufa 2.1 >= Lufa 2.4 > sandy soil > Lufa 2.2) and compounds (diniconazole > uniconazole) and was enantioselective. Earthworms preferentially accumulated R-uniconazole as a result of faster elimination of the S-form, which was evidenced from the enantiomer-specific uptake/elimination rate constants derived from the bioaccumulation profiles. Our results suggest that multigeneration exposure studies can advantageously be used for assessing the long-term and trans-general effects of pesticides. Also, the enantioselectivity in bioaccumulation observed for both uniconazole and diniconazole suggests that enantioselectivity in the fate and effects should be considered when exploring ways for safer and sustainable use of chiral pesticides.
ER  -

ŠKULCOVÁ, Lucia, Naveen NJATTUVETTY CHANDRAN and Lucie BIELSKÁ. Chiral conazole fungicides - (Enantioselective) terrestrial bioaccumulation and aquatic toxicity. \textit{Science of the Total Environment}. Amsterdam: Elsevier Science, 2020, vol.~743, November 2020, p.~1-12. ISSN~0048-9697. Available from: https://dx.doi.org/10.1016/j.scitotenv.2020.140821.

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