Detailed Information on Publication Record
2021
LncRNAs in adaptive immunity: role in physiological and pathological conditions
ZENI, Pedro and Marek MRÁZBasic information
Original name
LncRNAs in adaptive immunity: role in physiological and pathological conditions
Authors
ZENI, Pedro (76 Brazil, belonging to the institution) and Marek MRÁZ (203 Czech Republic, guarantor, belonging to the institution)
Edition
RNA Biology, Philadelphia, Taylor & Francis Inc, 2021, 1547-6286
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10601 Cell biology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.766
RIV identification code
RIV/00216224:14740/21:00120867
Organization unit
Central European Institute of Technology
UT WoS
000587536300001
Keywords in English
LncRNAs; Adaptive immunity; T cell; B cell; Lymphocyte development; B; T cell activation; T cell polarization; Autoimmune diseases; Leukaemia; Lymphoma
Tags
International impact, Reviewed
Změněno: 5/4/2022 14:09, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
The adaptive immune system is responsible for generating immunological response and immunological memory. Regulation of adaptive immunity including B cell and T cell biology was mainly understood from the protein and microRNA perspective. However, long non-coding RNAs (lncRNAs) are an emerging class of non-coding RNAs (ncRNAs) that influence key factors in lymphocyte biology such as NOTCH, PAX5, MYC and EZH2. LncRNAs were described to modulate lymphocyte activation by regulating pathways such as NFAT, NF kappa B, MYC, interferon and TCR/BCR signalling (NRON, NKILA, BCALM, GAS5, PVT1), and cell effector functions (IFNG-AS1, TH2-LCR). Here we review lncRNA involvement in adaptive immunity and the implications for autoimmune diseases (multiple sclerosis, inflammatory bowel disease, rheumatoid arthritis) and T/B cell leukaemias and lymphomas (CLL, MCL, DLBCL, T-ALL). It is becoming clear that lncRNAs are important in adaptive immune response and provide new insights into its orchestration.