OPTIMIZATION OF EXPRESSSION AND PURIFICATION OF FRAGMENT FROM TAU PROTEIN

PLEŠINGROVÁ, Klára, Norbert GAŠPARIK and Jozef HRITZ. OPTIMIZATION OF EXPRESSSION AND PURIFICATION OF FRAGMENT FROM TAU PROTEIN. In XX. Workshop of Biophysical Chemists and Electrochemists. 2020. ISBN 978-80-210-9655-4.

Basic information

Original name

OPTIMIZATION OF EXPRESSSION AND PURIFICATION OF FRAGMENT FROM TAU PROTEIN

Authors

PLEŠINGROVÁ, Klára, Norbert GAŠPARIK and Jozef HRITZ

Edition

XX. Workshop of Biophysical Chemists and Electrochemists, 2020

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Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Organization unit

Central European Institute of Technology

ISBN

978-80-210-9655-4

Keywords in English

Tau protein

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Abstract

V originále

Tau protein is abundant in the central nervous system, where it stabilizes microtubules by binding to the interface between tubulin sub-units [1,2]. Hyperphosphorylation of Tau leads to aggregation of protein and disruption of normal function of the neurons. These disorders can cause neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disease [3,4]. This work is focused on a short fragment from Tau protein, which has a key role in microtubule binding [2].

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Links

LM2018127, research and development project

Name: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB) Investor: Ministry of Education, Youth and Sports of the CR