Childhood cancer epidemiology in the Czech Republic (1994–2016)

J 2020

Childhood cancer epidemiology in the Czech Republic (1994–2016)

KREJČÍ, Denisa, Michaela ZAPLETALOVÁ, Ivana KATINOVÁ, Viera BAJČIOVÁ, Peter MÚDRY et. al.

Basic information

Original name

Childhood cancer epidemiology in the Czech Republic (1994–2016)

Authors

KREJČÍ, Denisa (203 Czech Republic, guarantor, belonging to the institution), Michaela ZAPLETALOVÁ (203 Czech Republic), Ivana KATINOVÁ (203 Czech Republic, belonging to the institution), Viera BAJČIOVÁ (703 Slovakia, belonging to the institution), Peter MÚDRY (203 Czech Republic, belonging to the institution), Vratislav ŠMELHAUS (203 Czech Republic), Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution), Jan STARÝ (203 Czech Republic), Riccardo CAPOCACCIA (380 Italy) and Ladislav DUŠEK (203 Czech Republic, belonging to the institution)

Edition

Cancer Epidemiology, Oxford, Elsevier, 2020, 1877-7821

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.984

RIV identification code

RIV/00216224:14110/20:00117433

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.canep.2020.101848

UT WoS

000596559500004

Keywords in English

childhood cancer; incidence; mortality; survival; czech republic

Abstract

V originále

Background: The knowledge of cancer burden in the population, its time trends and the possibility of international comparison is an important starting point for cancer control programmes. Our study aimed to evaluate trends in childhood cancer epidemiology of patients aged 0–14 years in the period 1994–2016 in the Czech Republic. Methods: Data on childhood cancers have been obtained from the Czech National Cancer Registry. These data were validated using the clinical database of childhood cancer patients and combined with data from death certificates. Incidence and mortality trends were assessed by the joinpoint regression method. The life tables method was used to calculate the overall age-standardised five-year survival. Results: The incidence trend was stable; the age-standardised (world) cancer incidence – ASR (W) – was 173.7 per 1 million children in the period 1994–2016. However, there was apparent significant decrease in mortality: ASR (W) dropped from 58.1 per 1 million children in 1994 to 21.4 per 1 million children in 2016. The overall fiveyear survival increased over time by 10 %. Statistically significant improvements in survival were observed in patients with lymphoid leukaemia, astrocytomas, neuroblastomas, osteosarcomas and rhabdomyosarcomas. Conclusion: Such a relevant increase in survival rates, and therefore also a decrease in mortality rates in the Czech Republic, is most likely due to improvements in diagnostic and treatment methods since the 1990s, which were facilitated by the concentration of childhood cancer patients in children’s cancer centres.

Links

MUNI/A/1409/2019, interní kód MU

Name: Personalizovaná léčba v dětské onkologii: na cestě k "liquid dynamic medicine" a "N-of-1 clinical trials"

Investor: Masaryk University, Category A

Citovat

KREJČÍ, Denisa, Michaela ZAPLETALOVÁ, Ivana KATINOVÁ, Viera BAJČIOVÁ, Peter MÚDRY, Vratislav ŠMELHAUS, Jaroslav ŠTĚRBA, Jan STARÝ, Riccardo CAPOCACCIA and Ladislav DUŠEK. Childhood cancer epidemiology in the Czech Republic (1994–2016). Cancer Epidemiology. Oxford: Elsevier, 2020, vol. 69, DEC 2020, p. 1-6. ISSN 1877-7821. Available from: https://dx.doi.org/10.1016/j.canep.2020.101848.

@article{1712136,
   author = {Krejčí, Denisa and Zapletalová, Michaela and Katinová, Ivana and Bajčiová, Viera and Múdry, Peter and Šmelhaus, Vratislav and Štěrba, Jaroslav and Starý, Jan and Capocaccia, Riccardo and Dušek, Ladislav},
   article_location = {Oxford},
   article_number = {DEC 2020},
   doi = {http://dx.doi.org/10.1016/j.canep.2020.101848},
   keywords = {childhood cancer; incidence; mortality; survival; czech republic},
   language = {eng},
   issn = {1877-7821},
   journal = {Cancer Epidemiology},
   title = {Childhood cancer epidemiology in the Czech Republic (1994–2016)},
   url = {https://www.sciencedirect.com/science/article/abs/pii/S187778212030182X?via%3Dihub},
   volume = {69},
   year = {2020}
}

TY  - JOUR
ID  - 1712136
AU  - Krejčí, Denisa - Zapletalová, Michaela - Katinová, Ivana - Bajčiová, Viera - Múdry, Peter - Šmelhaus, Vratislav - Štěrba, Jaroslav - Starý, Jan - Capocaccia, Riccardo - Dušek, Ladislav
PY  - 2020
TI  - Childhood cancer epidemiology in the Czech Republic (1994–2016)
JF  - Cancer Epidemiology
VL  - 69
IS  - DEC 2020
SP  - 1-6
EP  - 1-6
PB  - Elsevier
SN  - 18777821
KW  - childhood cancer
KW  - incidence
KW  - mortality
KW  - survival
KW  - czech republic
UR  - https://www.sciencedirect.com/science/article/abs/pii/S187778212030182X?via%3Dihub
L2  - https://www.sciencedirect.com/science/article/abs/pii/S187778212030182X?via%3Dihub
N2  - Background: The knowledge of cancer burden in the population, its time trends and the possibility of international comparison is an important starting point for cancer control programmes. Our study aimed to evaluate trends in childhood cancer epidemiology of patients aged 0–14 years in the period 1994–2016 in the Czech Republic. Methods: Data on childhood cancers have been obtained from the Czech National Cancer Registry. These data were validated using the clinical database of childhood cancer patients and combined with data from death certificates. Incidence and mortality trends were assessed by the joinpoint regression method. The life tables method was used to calculate the overall age-standardised five-year survival. Results: The incidence trend was stable; the age-standardised (world) cancer incidence – ASR (W) – was 173.7 per 1 million children in the period 1994–2016. However, there was apparent significant decrease in mortality: ASR (W) dropped from 58.1 per 1 million children in 1994 to 21.4 per 1 million children in 2016. The overall fiveyear survival increased over time by 10 %. Statistically significant improvements in survival were observed in patients with lymphoid leukaemia, astrocytomas, neuroblastomas, osteosarcomas and rhabdomyosarcomas. Conclusion: Such a relevant increase in survival rates, and therefore also a decrease in mortality rates in the Czech Republic, is most likely due to improvements in diagnostic and treatment methods since the 1990s, which were facilitated by the concentration of childhood cancer patients in children’s cancer centres.
ER  -

KREJČÍ, Denisa, Michaela ZAPLETALOVÁ, Ivana KATINOVÁ, Viera BAJČIOVÁ, Peter MÚDRY, Vratislav ŠMELHAUS, Jaroslav ŠTĚRBA, Jan STARÝ, Riccardo CAPOCACCIA and Ladislav DUŠEK. Childhood cancer epidemiology in the Czech Republic (1994–2016). \textit{Cancer Epidemiology}. Oxford: Elsevier, 2020, vol.~69, DEC 2020, p.~1-6. ISSN~1877-7821. Available from: https://dx.doi.org/10.1016/j.canep.2020.101848.

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