MR Diffusion Properties of Cervical Spinal Cord as a Predictor
of Progression to Multiple Sclerosis in Patients with
Clinically Isolated Syndrome

J 2021

MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome

DOSTÁL, Marek, Miloš KEŘKOVSKÝ, Jakub STULÍK, Josef BEDNAŘÍK, Petra PRAKSOVÁ et. al.

Basic information

Original name

MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome

Authors

DOSTÁL, Marek (203 Czech Republic, belonging to the institution), Miloš KEŘKOVSKÝ (203 Czech Republic, guarantor, belonging to the institution), Jakub STULÍK (203 Czech Republic, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution), Petra PRAKSOVÁ (203 Czech Republic, belonging to the institution), Monika HULOVÁ (203 Czech Republic, belonging to the institution), Yvonne BENEŠOVÁ (203 Czech Republic, belonging to the institution), Eva KORIŤÁKOVÁ (203 Czech Republic, belonging to the institution), Andrea ŠPRLÁKOVÁ-PUKOVÁ (203 Czech Republic, belonging to the institution) and Marek MECHL (203 Czech Republic, belonging to the institution)

Edition

Journal of Neuroimaging, Hoboken, Wiley-Blackwell, 2021, 1051-2284

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30224 Radiology, nuclear medicine and medical imaging

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.324

RIV identification code

RIV/00216224:14110/21:00120081

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1111/jon.12808

UT WoS

000594060100001

Keywords in English

clinically isolated syndrome; diffusion tensor imaging; multiple sclerosis; spine

Abstract

V originále

BACKGROUND AND PURPOSE This study's aim was to investigate diffusion properties of the cervical spinal cord in patients with clinically isolated syndrome (CIS) through analysis of diffusion tensor imaging (DTI) data and thereby to assess the capacity of this technique for predicting the progression of CIS to clinically definite multiple sclerosis (CDMS). METHODS The study groups were comprised of 47 patients with CIS (15 of them with progression to CDMS within 2 years of follow-up) and 57 asymptomatic controls. All patients and controls had undergone magnetic resonance imaging (MRI) of the cervical spine including DTI and brain MRI. Methodological approaches included histogram analysis of the cervical cord's diffusion parameters and evaluation of T2 hyperintense lesions of the spinal cord and brain. All parameters were compared between the study groups. Sensitivity and specificity calculations were then performed with a view to predicting conversion to CDMS. RESULTS The patient subgroups defined by progression to CDMS differed significantly in values of fractional anisotropy (FA) kurtosis measured within white matter (WM) and normal-appearing WM (NAWM). The same parameters also differed significantly when patients with progression to CDMS were compared to healthy controls. Receiver operating characteristic (ROC) analysis revealed sensitivity and specificity of FA kurtosis of WM and NAWM of 93% and 72%, respectively, in terms of predicting CIS to CDMS progression. CONCLUSION This study presents evidence that histogram analysis of diffusion parameters of the cervical spinal cord in patients with CIS may be helpful in predicting conversion to CDMS.

Links

MUNI/A/1488/2019, interní kód MU

Name: Význam radiologických intervencí a pokročilých zobrazovacích metod v diagnostice a léčbě onkologických pacientů

Investor: Masaryk University, Category A

NV15-32133A, research and development project

Name: Predikce konverze klinicky izolovaného syndromu do roztroušené sklerózy pomocí pokročilých technik zobrazení magnetickou rezonancí

Citovat

DOSTÁL, Marek, Miloš KEŘKOVSKÝ, Jakub STULÍK, Josef BEDNAŘÍK, Petra PRAKSOVÁ, Monika HULOVÁ, Yvonne BENEŠOVÁ, Eva KORIŤÁKOVÁ, Andrea ŠPRLÁKOVÁ-PUKOVÁ and Marek MECHL. MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome. Journal of Neuroimaging. Hoboken: Wiley-Blackwell, 2021, vol. 31, No 1, p. 108-114. ISSN 1051-2284. Available from: https://dx.doi.org/10.1111/jon.12808.

@article{1713456,
   author = {Dostál, Marek and Keřkovský, Miloš and Stulík, Jakub and Bednařík, Josef and Praksová, Petra and Hulová, Monika and Benešová, Yvonne and Koriťáková, Eva and ŠprlákováandPuková, Andrea and Mechl, Marek},
   article_location = {Hoboken},
   article_number = {1},
   doi = {http://dx.doi.org/10.1111/jon.12808},
   keywords = {clinically isolated syndrome; diffusion tensor imaging; multiple sclerosis; spine},
   language = {eng},
   issn = {1051-2284},
   journal = {Journal of Neuroimaging},
   title = {MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/jon.12808},
   volume = {31},
   year = {2021}
}

TY  - JOUR
ID  - 1713456
AU  - Dostál, Marek - Keřkovský, Miloš - Stulík, Jakub - Bednařík, Josef - Praksová, Petra - Hulová, Monika - Benešová, Yvonne - Koriťáková, Eva - Šprláková-Puková, Andrea - Mechl, Marek
PY  - 2021
TI  - MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome
JF  - Journal of Neuroimaging
VL  - 31
IS  - 1
SP  - 108-114
EP  - 108-114
PB  - Wiley-Blackwell
SN  - 10512284
KW  - clinically isolated syndrome
KW  - diffusion tensor imaging
KW  - multiple sclerosis
KW  - spine
UR  - https://onlinelibrary.wiley.com/doi/10.1111/jon.12808
L2  - https://onlinelibrary.wiley.com/doi/10.1111/jon.12808
N2  - BACKGROUND AND PURPOSE This study's aim was to investigate diffusion properties of the cervical spinal cord in patients with clinically isolated syndrome (CIS) through analysis of diffusion tensor imaging (DTI) data and thereby to assess the capacity of this technique for predicting the progression of CIS to clinically definite multiple sclerosis (CDMS). METHODS The study groups were comprised of 47 patients with CIS (15 of them with progression to CDMS within 2 years of follow-up) and 57 asymptomatic controls. All patients and controls had undergone magnetic resonance imaging (MRI) of the cervical spine including DTI and brain MRI. Methodological approaches included histogram analysis of the cervical cord's diffusion parameters and evaluation of T2 hyperintense lesions of the spinal cord and brain. All parameters were compared between the study groups. Sensitivity and specificity calculations were then performed with a view to predicting conversion to CDMS. RESULTS The patient subgroups defined by progression to CDMS differed significantly in values of fractional anisotropy (FA) kurtosis measured within white matter (WM) and normal-appearing WM (NAWM). The same parameters also differed significantly when patients with progression to CDMS were compared to healthy controls. Receiver operating characteristic (ROC) analysis revealed sensitivity and specificity of FA kurtosis of WM and NAWM of 93% and 72%, respectively, in terms of predicting CIS to CDMS progression. CONCLUSION This study presents evidence that histogram analysis of diffusion parameters of the cervical spinal cord in patients with CIS may be helpful in predicting conversion to CDMS.
ER  -

DOSTÁL, Marek, Miloš KEŘKOVSKÝ, Jakub STULÍK, Josef BEDNAŘÍK, Petra PRAKSOVÁ, Monika HULOVÁ, Yvonne BENEŠOVÁ, Eva KORIŤÁKOVÁ, Andrea ŠPRLÁKOVÁ-PUKOVÁ and Marek MECHL. MR Diffusion Properties of Cervical Spinal Cord as a Predictor of Progression to Multiple Sclerosis in Patients with Clinically Isolated Syndrome. \textit{Journal of Neuroimaging}. Hoboken: Wiley-Blackwell, 2021, vol.~31, No~1, p.~108-114. ISSN~1051-2284. Available from: https://dx.doi.org/10.1111/jon.12808.

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