Needles in a haystack: Extremely rare invasive fungal
infections reported in FungiScope (R)-Global Registry for
Emerging Fungal Infections

J 2020

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections

SALMANTON-GARCIA, Jon, Philipp KOEHLER, Anupma KINDO, Iker FALCES-ROMERO, Julio GARCIA-RODRIGUEZ et. al.

Basic information

Original name

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections

Authors

SALMANTON-GARCIA, Jon, Philipp KOEHLER, Anupma KINDO, Iker FALCES-ROMERO, Julio GARCIA-RODRIGUEZ, Zdeněk RÁČIL (203 Czech Republic, belonging to the institution), Sharon C. A. CHEN, Nikolai KLIMKO, Guillaume DESOUBEAUX, George R. THOMPSON, Miguel-Angel BENITEZ-PENUELA, Jose-Yesid RODRIGUEZ, Donald C. SHEPPARD, Martin HOENIGL, Yohann LE GOVIC, Hamid BADALI, John W. BADDLEY, Jagdish CHANDER, Paul R. INGRAM, Diana L. PAKSTIS, Sibylle C. MELLINGHOFF, Serkan ATICI, Simone CESARO, Arunaloke CHAKRABARTI, Damien DUPONT, Gloria M. GONZALEZ, Lorant HATVANI, Raoul HERBRECHT, Galina KLYASOVA, Cornelia LASS-FLORL, Mihai MARES, Kathleen MULLANE, Donald C. VINH, Hilmar WISPLINGHOFF, Michaela LACKNER, Oliver A. CORNELY and Danila SEIDEL

Edition

The Journal of infection, London, Academic Press, 2020, 0163-4453

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 6.072

RIV identification code

RIV/00216224:14110/20:00117464

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jinf.2020.08.015

UT WoS

000586323400017

Keywords in English

Rare; Invasive fungal infections; Registry; Mold; Yeast

Abstract

V originále

Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScope (R) registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope (R). Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Citovat

SALMANTON-GARCIA, Jon, Philipp KOEHLER, Anupma KINDO, Iker FALCES-ROMERO, Julio GARCIA-RODRIGUEZ, Zdeněk RÁČIL, Sharon C. A. CHEN, Nikolai KLIMKO, Guillaume DESOUBEAUX, George R. THOMPSON, Miguel-Angel BENITEZ-PENUELA, Jose-Yesid RODRIGUEZ, Donald C. SHEPPARD, Martin HOENIGL, Yohann LE GOVIC, Hamid BADALI, John W. BADDLEY, Jagdish CHANDER, Paul R. INGRAM, Diana L. PAKSTIS, Sibylle C. MELLINGHOFF, Serkan ATICI, Simone CESARO, Arunaloke CHAKRABARTI, Damien DUPONT, Gloria M. GONZALEZ, Lorant HATVANI, Raoul HERBRECHT, Galina KLYASOVA, Cornelia LASS-FLORL, Mihai MARES, Kathleen MULLANE, Donald C. VINH, Hilmar WISPLINGHOFF, Michaela LACKNER, Oliver A. CORNELY and Danila SEIDEL. Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections. The Journal of infection. London: Academic Press, 2020, vol. 81, No 5, p. 802-815. ISSN 0163-4453. Available from: https://dx.doi.org/10.1016/j.jinf.2020.08.015.

@article{1713497,
   author = {SalmantonandGarcia, Jon and Koehler, Philipp and Kindo, Anupma and FalcesandRomero, Iker and GarciaandRodriguez, Julio and Ráčil, Zdeněk and Chen, Sharon C. A. and Klimko, Nikolai and Desoubeaux, Guillaume and Thompson, George R. and BenitezandPenuela, MiguelandAngel and Rodriguez, JoseandYesid and Sheppard, Donald C. and Hoenigl, Martin and Le Govic, Yohann and Badali, Hamid and Baddley, John W. and Chander, Jagdish and Ingram, Paul R. and Pakstis, Diana L. and Mellinghoff, Sibylle C. and Atici, Serkan and Cesaro, Simone and Chakrabarti, Arunaloke and Dupont, Damien and Gonzalez, Gloria M. and Hatvani, Lorant and Herbrecht, Raoul and Klyasova, Galina and LassandFlorl, Cornelia and Mares, Mihai and Mullane, Kathleen and Vinh, Donald C. and Wisplinghoff, Hilmar and Lackner, Michaela and Cornely, Oliver A. and Seidel, Danila},
   article_location = {London},
   article_number = {5},
   doi = {http://dx.doi.org/10.1016/j.jinf.2020.08.015},
   keywords = {Rare; Invasive fungal infections; Registry; Mold; Yeast},
   language = {eng},
   issn = {0163-4453},
   journal = {The Journal of infection},
   title = {Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections},
   url = {https://www.journalofinfection.com/article/S0163-4453(20)30549-1/fulltext},
   volume = {81},
   year = {2020}
}

TY  - JOUR
ID  - 1713497
AU  - Salmanton-Garcia, Jon - Koehler, Philipp - Kindo, Anupma - Falces-Romero, Iker - Garcia-Rodriguez, Julio - Ráčil, Zdeněk - Chen, Sharon C. A. - Klimko, Nikolai - Desoubeaux, Guillaume - Thompson, George R. - Benitez-Penuela, Miguel-Angel - Rodriguez, Jose-Yesid - Sheppard, Donald C. - Hoenigl, Martin - Le Govic, Yohann - Badali, Hamid - Baddley, John W. - Chander, Jagdish - Ingram, Paul R. - Pakstis, Diana L. - Mellinghoff, Sibylle C. - Atici, Serkan - Cesaro, Simone - Chakrabarti, Arunaloke - Dupont, Damien - Gonzalez, Gloria M. - Hatvani, Lorant - Herbrecht, Raoul - Klyasova, Galina - Lass-Florl, Cornelia - Mares, Mihai - Mullane, Kathleen - Vinh, Donald C. - Wisplinghoff, Hilmar - Lackner, Michaela - Cornely, Oliver A. - Seidel, Danila
PY  - 2020
TI  - Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections
JF  - The Journal of infection
VL  - 81
IS  - 5
SP  - 802-815
EP  - 802-815
PB  - Academic Press
SN  - 01634453
KW  - Rare
KW  - Invasive fungal infections
KW  - Registry
KW  - Mold
KW  - Yeast
UR  - https://www.journalofinfection.com/article/S0163-4453(20)30549-1/fulltext
L2  - https://www.journalofinfection.com/article/S0163-4453(20)30549-1/fulltext
N2  - Objectives: Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI. Methods: Extremely rare IFI collected in the FungiScope (R) registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales. Results: Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope (R). Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales. Conclusions: Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens. (C) 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
ER  -

SALMANTON-GARCIA, Jon, Philipp KOEHLER, Anupma KINDO, Iker FALCES-ROMERO, Julio GARCIA-RODRIGUEZ, Zdeněk RÁČIL, Sharon C. A. CHEN, Nikolai KLIMKO, Guillaume DESOUBEAUX, George R. THOMPSON, Miguel-Angel BENITEZ-PENUELA, Jose-Yesid RODRIGUEZ, Donald C. SHEPPARD, Martin HOENIGL, Yohann LE GOVIC, Hamid BADALI, John W. BADDLEY, Jagdish CHANDER, Paul R. INGRAM, Diana L. PAKSTIS, Sibylle C. MELLINGHOFF, Serkan ATICI, Simone CESARO, Arunaloke CHAKRABARTI, Damien DUPONT, Gloria M. GONZALEZ, Lorant HATVANI, Raoul HERBRECHT, Galina KLYASOVA, Cornelia LASS-FLORL, Mihai MARES, Kathleen MULLANE, Donald C. VINH, Hilmar WISPLINGHOFF, Michaela LACKNER, Oliver A. CORNELY and Danila SEIDEL. Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope (R)-Global Registry for Emerging Fungal Infections. \textit{The Journal of infection}. London: Academic Press, 2020, vol.~81, No~5, p.~802-815. ISSN~0163-4453. Available from: https://dx.doi.org/10.1016/j.jinf.2020.08.015.

Detailed Information on Publication Record