Coordinated labio-lingual asymmetries in dental and bone
development create a symmetrical acrodont dentition

J 2020

Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition

KAVKOVÁ, M., Marie ŠULCOVÁ, Jana DUMKOVÁ, O. ZAHRADNÍČEK, J. KAISER et. al.

Basic information

Original name

Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition

Authors

KAVKOVÁ, M., Marie ŠULCOVÁ (203 Czech Republic, belonging to the institution), Jana DUMKOVÁ (203 Czech Republic, belonging to the institution), O. ZAHRADNÍČEK, J. KAISER, A. S. TUCKER, T. ZIKMUND and Marcela BUCHTOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

Scientific Reports, Berlin, Nature Research, 2020, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30208 Dentistry, oral surgery and medicine

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.379

RIV identification code

RIV/00216224:14310/20:00114615

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1038/s41598-020-78939-2

UT WoS

000603657800006

Keywords in English

Body patterning; Bone development

Abstract

V originále

Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is held in place on the labial side only. Pleurodont teeth are characterized by significantly asymmetrical development of the labial and lingual sides of the cervical loop, which later leads to uneven deposition of hard tissue. On the other hand, acrodont teeth found in lizards of the Acrodonta clade (i.e. agamas, chameleons) are symmetrically ankylosed to the jaw bone. Here, we have focused on the formation of the symmetrical acrodont dentition of the veiled chameleon (Chamaeleo calyptratus). Intriguingly, our results revealed distinct asymmetries in morphology of the labial and lingual sides of the cervical loop during early developmental stages, both at the gross and ultrastructural level, with specific patterns of cell proliferation and stem cell marker expression. Asymmetrical expression of ST14 was also observed, with a positive domain on the lingual side of the cervical loop overlapping with the SOX2 domain. In contrast, micro-CT analysis of hard tissues revealed that deposition of dentin and enamel was largely symmetrical at the mineralization stage, highlighting the difference between cervical loop morphology during early development and differentiation of odontoblasts throughout later odontogenesis. In conclusion, the early asymmetrical development of the enamel organ seems to be a plesiomorphic character for all squamate reptiles, while symmetrical and precisely orchestrated deposition of hard tissue during tooth formation in acrodont dentitions probably represents a novelty in the Acrodonta clade.

Links

GA17-14886S, research and development project

Name: Molekulární a buněčná dynamika rozhraní zubu a kosti u modelových druhů s akrodontní, pleurodontní a tekodontní denticí

Investor: Czech Science Foundation

LM2018129, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministry of Education, Youth and Sports of the CR

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

KAVKOVÁ, M., Marie ŠULCOVÁ, Jana DUMKOVÁ, O. ZAHRADNÍČEK, J. KAISER, A. S. TUCKER, T. ZIKMUND and Marcela BUCHTOVÁ. Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition. Scientific Reports. Berlin: Nature Research, 2020, vol. 10, No 1, p. 1-16. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-78939-2.

@article{1717837,
   author = {Kavková, M. and Šulcová, Marie and Dumková, Jana and Zahradníček, O. and Kaiser, J. and Tucker, A. S. and Zikmund, T. and Buchtová, Marcela},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-020-78939-2},
   keywords = {Body patterning; Bone development},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition},
   url = {https://doi.org/10.1038/s41598-020-78939-2},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1717837
AU  - Kavková, M. - Šulcová, Marie - Dumková, Jana - Zahradníček, O. - Kaiser, J. - Tucker, A. S. - Zikmund, T. - Buchtová, Marcela
PY  - 2020
TI  - Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition
JF  - Scientific Reports
VL  - 10
IS  - 1
SP  - 1-16
EP  - 1-16
PB  - Nature Research
SN  - 20452322
KW  - Body patterning
KW  - Bone development
UR  - https://doi.org/10.1038/s41598-020-78939-2
L2  - https://doi.org/10.1038/s41598-020-78939-2
N2  - Organs throughout the body develop both asymmetrically and symmetrically. Here, we assess how symmetrical teeth in reptiles can be created from asymmetrical tooth germs. Teeth of lepidosaurian reptiles are mostly anchored to the jaw bones by pleurodont ankylosis, where the tooth is held in place on the labial side only. Pleurodont teeth are characterized by significantly asymmetrical development of the labial and lingual sides of the cervical loop, which later leads to uneven deposition of hard tissue. On the other hand, acrodont teeth found in lizards of the Acrodonta clade (i.e. agamas, chameleons) are symmetrically ankylosed to the jaw bone. Here, we have focused on the formation of the symmetrical acrodont dentition of the veiled chameleon (Chamaeleo calyptratus). Intriguingly, our results revealed distinct asymmetries in morphology of the labial and lingual sides of the cervical loop during early developmental stages, both at the gross and ultrastructural level, with specific patterns of cell proliferation and stem cell marker expression. Asymmetrical expression of ST14 was also observed, with a positive domain on the lingual side of the cervical loop overlapping with the SOX2 domain. In contrast, micro-CT analysis of hard tissues revealed that deposition of dentin and enamel was largely symmetrical at the mineralization stage, highlighting the difference between cervical loop morphology during early development and differentiation of odontoblasts throughout later odontogenesis. In conclusion, the early asymmetrical development of the enamel organ seems to be a plesiomorphic character for all squamate reptiles, while symmetrical and precisely orchestrated deposition of hard tissue during tooth formation in acrodont dentitions probably represents a novelty in the Acrodonta clade.
ER  -

KAVKOVÁ, M., Marie ŠULCOVÁ, Jana DUMKOVÁ, O. ZAHRADNÍČEK, J. KAISER, A. S. TUCKER, T. ZIKMUND and Marcela BUCHTOVÁ. Coordinated labio-lingual asymmetries in dental and bone development create a symmetrical acrodont dentition. \textit{Scientific Reports}. Berlin: Nature Research, 2020, vol.~10, No~1, p.~1-16. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-78939-2.

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