KAYSER, S., M. A. ELLIOTT, M. LUSKIN, A. M. BRUNNER, M. KRAMER, Zdeněk RÁČIL, Zuzana NOVÁKOVÁ, P. CETKOVSKY, J. NOVAK, F. STOELZEL, C. THIEDE, C. MULLER-TIDOW, U. PLATZBECKER, C. ROLLIG, R. F. SCHLENK and M. J. LEVIS. Characteristics and Outcome of Patients with Core Binding Factor Acute Myeloid Leukemia and FLT3-ITD: Results from an International Collaboration. 2019. ISSN 0006-4971. Available from: https://dx.doi.org/10.1182/blood-2019-125317. |
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@proceedings{1718078, author = {Kayser, S. and Elliott, M. A. and Luskin, M. and Brunner, A. M. and Kramer, M. and Ráčil, Zdeněk and Nováková, Zuzana and Cetkovsky, P. and Novak, J. and Stoelzel, F. and Thiede, C. and MullerandTidow, C. and Platzbecker, U. and Rollig, C. and Schlenk, R. F. and Levis, M. J.}, doi = {http://dx.doi.org/10.1182/blood-2019-125317}, keywords = {Core Binding Factor Acute Myeloid Leukemia; FLT3-ITD}, language = {eng}, title = {Characteristics and Outcome of Patients with Core Binding Factor Acute Myeloid Leukemia and FLT3-ITD: Results from an International Collaboration}, url = {https://ashpublications.org/blood/article/134/Supplement_1/2693/423109/Characteristics-and-Outcome-of-Patients-with-Core}, year = {2019} }
TY - CONF ID - 1718078 AU - Kayser, S. - Elliott, M. A. - Luskin, M. - Brunner, A. M. - Kramer, M. - Ráčil, Zdeněk - Nováková, Zuzana - Cetkovsky, P. - Novak, J. - Stoelzel, F. - Thiede, C. - Muller-Tidow, C. - Platzbecker, U. - Rollig, C. - Schlenk, R. F. - Levis, M. J. PY - 2019 TI - Characteristics and Outcome of Patients with Core Binding Factor Acute Myeloid Leukemia and FLT3-ITD: Results from an International Collaboration KW - Core Binding Factor Acute Myeloid Leukemia KW - FLT3-ITD UR - https://ashpublications.org/blood/article/134/Supplement_1/2693/423109/Characteristics-and-Outcome-of-Patients-with-Core L2 - https://ashpublications.org/blood/article/134/Supplement_1/2693/423109/Characteristics-and-Outcome-of-Patients-with-Core N2 - Core binding factor acute myeloid leukemia (CBF-AML) is defined by the presence of either t(8;21)(q22;q22) or inv(16)(p13.1q22)/t(16;16)(p13.1;q22) and is associated with a favorable outcome, particularly if treated with repetitive cycles of high-dose cytarabine as post-remission therapy. Long-time 10-year overall survival (OS) rate was reported of 58% in FLT3-ITD negative patients (pts; Allen et al. Leukemia 2013). Nevertheless, 30-40% CBF-AML pts experience relapse. FLT3-ITD mutations occur in roughly 5-10% of adult CBF-AML. However, their prognostic relevance is still controversial. ER -
KAYSER, S., M. A. ELLIOTT, M. LUSKIN, A. M. BRUNNER, M. KRAMER, Zdeněk RÁČIL, Zuzana NOVÁKOVÁ, P. CETKOVSKY, J. NOVAK, F. STOELZEL, C. THIEDE, C. MULLER-TIDOW, U. PLATZBECKER, C. ROLLIG, R. F. SCHLENK and M. J. LEVIS. \textit{Characteristics and Outcome of Patients with Core Binding Factor Acute Myeloid Leukemia and FLT3-ITD: Results from an International Collaboration}. 2019. ISSN~0006-4971. Available from: https://dx.doi.org/10.1182/blood-2019-125317.
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