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@article{1718936,
author = {Cibula, David and Slama, Jiri and Dostalek, Lukas and Fischerova, Daniela and Germanova, Anna and Fruhauf, Filip and Dundr, Pavel and Nemejcova, Kristyna and Jarkovský, Jiří and Sebestova, Silvie and Burgetova, Andrea and Borcinova, Martina and Kocian, Roman},
article_location = {London},
article_number = {6},
doi = {http://dx.doi.org/10.1038/s41416-020-01204-w},
keywords = {cervical cancer; novel prognostic marker},
language = {eng},
issn = {0007-0920},
journal = {British journal of cancer},
title = {Tumour-free distance: a novel prognostic marker in patients with early-stage cervical cancer treated by primary surgery},
url = {https://www.nature.com/articles/s41416-020-01204-w},
volume = {124},
year = {2021}
}
TY - JOUR
ID - 1718936
AU - Cibula, David - Slama, Jiri - Dostalek, Lukas - Fischerova, Daniela - Germanova, Anna - Fruhauf, Filip - Dundr, Pavel - Nemejcova, Kristyna - Jarkovský, Jiří - Sebestova, Silvie - Burgetova, Andrea - Borcinova, Martina - Kocian, Roman
PY - 2021
TI - Tumour-free distance: a novel prognostic marker in patients with early-stage cervical cancer treated by primary surgery
JF - British journal of cancer
VL - 124
IS - 6
SP - 1121-1129
EP - 1121-1129
PB - Nature Publishing Group
SN - 00070920
KW - cervical cancer
KW - novel prognostic marker
UR - https://www.nature.com/articles/s41416-020-01204-w
L2 - https://www.nature.com/articles/s41416-020-01204-w
N2 - Background Models predicting recurrence risk (RR) of cervical cancer are used to tailor adjuvant treatment after radical surgery. The goal of our study was to compare available prognostic factors and to develop a prognostic model that would be easy to standardise and use in routine clinical practice. Methods All consecutive patients with early-stage cervical cancer treated by primary surgery in a single referral centre (01/2007-12/2016) were eligible if assessed by standardised protocols for pre-operative imaging and pathology. Fifteen prognostic markers were evaluated in 379 patients, out of which 320 lymph node (LN)-negative. Results The best predictive model for the whole cohort entailed a combination of tumour-free distance (TFD) <= 3.5 mm and LN positivity, which separated two subgroups with a substantially distinct RR 36% and 6.5%, respectively. In LN-negative patients, a combination of TFD <= 3.5 mm and adenosquamous tumour type separated a group of nine patients with RR 33% from the rest of the group with 6% RR. Conclusions A newly identified prognostic marker, TFD, surpassed all traditional tumour-related markers in the RR assessment. Predictive models combining TFD, which can be easily accessed on pre-operative imaging, with LN status or tumour type can be used in daily practice and can help to identify patients with the highest RR.
ER -
CIBULA, David, Jiri SLAMA, Lukas DOSTALEK, Daniela FISCHEROVA, Anna GERMANOVA, Filip FRUHAUF, Pavel DUNDR, Kristyna NEMEJCOVA, Jiří JARKOVSKÝ, Silvie SEBESTOVA, Andrea BURGETOVA, Martina BORCINOVA and Roman KOCIAN. Tumour-free distance: a novel prognostic marker in patients with early-stage cervical cancer treated by primary surgery. \textit{British journal of cancer}. London: Nature Publishing Group, 2021, vol.~124, No~6, p.~1121-1129. ISSN~0007-0920. Available from: https://dx.doi.org/10.1038/s41416-020-01204-w.
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