Sensory and pain modulation profiles of ongoing central
neuropathic extremity pain in multiple sclerosis

J 2021

Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis

SROTOVA, Iva, Jan KOČICA, Jan VOLLERT, Jan KOLČAVA, Monika HULOVÁ et. al.

Basic information

Original name

Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis

Authors

SROTOVA, Iva (203 Czech Republic), Jan KOČICA (203 Czech Republic, belonging to the institution), Jan VOLLERT, Jan KOLČAVA (203 Czech Republic, belonging to the institution), Monika HULOVÁ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Eva VLČKOVÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

European Journal of Pain, Hoboken, Wiley, 2021, 1090-3801

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.651

RIV identification code

RIV/00216224:14110/21:00120082

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1002/ejp.1695

UT WoS

000592953400001

Keywords in English

entral neuropathic extremity pain; multiple sclerosis

Abstract

V originále

Background Central neuropathic extremity pain (CNEP) is the most frequent type of pain in multiple sclerosis (MS). The aim of the present study was to evaluate sensory and pain modulation profiles in MS patients with CNEP. Methods In a single-centre observational study, a group of 56 CNEP MS patients was compared with 63 pain-free MS patients and with a sex- and age-adjusted control group. Standardized quantitative sensory testing (QST) and dynamic QST (dQST) protocols comprising temporal summation and conditioned pain modulation tests were used to compare sensory profiles. Results Loss-type QST abnormalities in both thermal and mechanical QST modalities prevailed in both MS subgroups and correlated significantly with higher degree of disability expressed as Expanded Disability Status Scale (EDSS). Comparison of sensory phenotypes disclosed a higher frequency of the 'sensory loss' prototypic sensory phenotype in the CNEP subgroup (30%) compared with pain-free MS patients (6%; p = .003). Conclusion The role of aging process and higher lesion load in the spinothalamocortical pathway might be possible explanation for pain development in this particular 'deafferentation' subtype of central neuropathic pain in MS. We were unable to support the role of central sensitization or endogenous facilitatory and inhibitory mechanisms in the development of CNEP in MS. Significance This article presents higher prevalence of the 'sensory loss' prototypic sensory phenotype in multiple sclerosis patients with central extremity neuropathic pain compared to pain-free patients. Higher degree of disability underlines the possible role of higher lesion load in the somatosensory pathways in this particular 'deafferentation' type of central neuropathic pain.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

MUNI/A/1325/2019, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)

Investor: Masaryk University, Category A

MUNI/A/1600/2020, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)

Investor: Masaryk University

NT13523, research and development project

Name: Specifické charakteristiky neuropatické bolesti centrálního a periferního typu

NV15-32133A, research and development project

Name: Predikce konverze klinicky izolovaného syndromu do roztroušené sklerózy pomocí pokročilých technik zobrazení magnetickou rezonancí

Citovat

SROTOVA, Iva, Jan KOČICA, Jan VOLLERT, Jan KOLČAVA, Monika HULOVÁ, Jiří JARKOVSKÝ, Ladislav DUŠEK, Josef BEDNAŘÍK and Eva VLČKOVÁ. Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis. European Journal of Pain. Hoboken: Wiley, 2021, vol. 25, No 3, p. 573-594. ISSN 1090-3801. Available from: https://dx.doi.org/10.1002/ejp.1695.

@article{1719076,
   author = {Srotova, Iva and Kočica, Jan and Vollert, Jan and Kolčava, Jan and Hulová, Monika and Jarkovský, Jiří and Dušek, Ladislav and Bednařík, Josef and Vlčková, Eva},
   article_location = {Hoboken},
   article_number = {3},
   doi = {http://dx.doi.org/10.1002/ejp.1695},
   keywords = {entral neuropathic extremity pain; multiple sclerosis},
   language = {eng},
   issn = {1090-3801},
   journal = {European Journal of Pain},
   title = {Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis},
   url = {https://onlinelibrary.wiley.com/doi/10.1002/ejp.1695},
   volume = {25},
   year = {2021}
}

TY  - JOUR
ID  - 1719076
AU  - Srotova, Iva - Kočica, Jan - Vollert, Jan - Kolčava, Jan - Hulová, Monika - Jarkovský, Jiří - Dušek, Ladislav - Bednařík, Josef - Vlčková, Eva
PY  - 2021
TI  - Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis
JF  - European Journal of Pain
VL  - 25
IS  - 3
SP  - 573-594
EP  - 573-594
PB  - Wiley
SN  - 10903801
KW  - entral neuropathic extremity pain
KW  - multiple sclerosis
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ejp.1695
L2  - https://onlinelibrary.wiley.com/doi/10.1002/ejp.1695
N2  - Background Central neuropathic extremity pain (CNEP) is the most frequent type of pain in multiple sclerosis (MS). The aim of the present study was to evaluate sensory and pain modulation profiles in MS patients with CNEP. Methods In a single-centre observational study, a group of 56 CNEP MS patients was compared with 63 pain-free MS patients and with a sex- and age-adjusted control group. Standardized quantitative sensory testing (QST) and dynamic QST (dQST) protocols comprising temporal summation and conditioned pain modulation tests were used to compare sensory profiles. Results Loss-type QST abnormalities in both thermal and mechanical QST modalities prevailed in both MS subgroups and correlated significantly with higher degree of disability expressed as Expanded Disability Status Scale (EDSS). Comparison of sensory phenotypes disclosed a higher frequency of the 'sensory loss' prototypic sensory phenotype in the CNEP subgroup (30%) compared with pain-free MS patients (6%; p = .003). Conclusion The role of aging process and higher lesion load in the spinothalamocortical pathway might be possible explanation for pain development in this particular 'deafferentation' subtype of central neuropathic pain in MS. We were unable to support the role of central sensitization or endogenous facilitatory and inhibitory mechanisms in the development of CNEP in MS. Significance This article presents higher prevalence of the 'sensory loss' prototypic sensory phenotype in multiple sclerosis patients with central extremity neuropathic pain compared to pain-free patients. Higher degree of disability underlines the possible role of higher lesion load in the somatosensory pathways in this particular 'deafferentation' type of central neuropathic pain.
ER  -

SROTOVA, Iva, Jan KOČICA, Jan VOLLERT, Jan KOLČAVA, Monika HULOVÁ, Jiří JARKOVSKÝ, Ladislav DUŠEK, Josef BEDNAŘÍK and Eva VLČKOVÁ. Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis. \textit{European Journal of Pain}. Hoboken: Wiley, 2021, vol.~25, No~3, p.~573-594. ISSN~1090-3801. Available from: https://dx.doi.org/10.1002/ejp.1695.

Detailed Information on Publication Record