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@article{1720297, author = {Strýček, Ondřej and Lamoš, Martin and Klimes, P. and Rektor, Ivan}, article_location = {SAN DIEGO}, article_number = {NOV}, doi = {http://dx.doi.org/10.1016/j.yebeh.2020.107409}, keywords = {Temporal lobe epilepsy; High-density EEG; Functional connectivity; Cognitive network}, language = {eng}, issn = {1525-5050}, journal = {EPILEPSY & BEHAVIOR}, title = {Cognitive task-related functional connectivity alterations in temporal lobe epilepsy}, url = {https://www.sciencedirect.com/science/article/pii/S1525505020305886?via%3Dihub}, volume = {112}, year = {2020} }
TY - JOUR ID - 1720297 AU - Strýček, Ondřej - Lamoš, Martin - Klimes, P. - Rektor, Ivan PY - 2020 TI - Cognitive task-related functional connectivity alterations in temporal lobe epilepsy JF - EPILEPSY & BEHAVIOR VL - 112 IS - NOV SP - 107409 EP - 107409 PB - ACADEMIC PRESS INC ELSEVIER SCIENCE SN - 15255050 KW - Temporal lobe epilepsy KW - High-density EEG KW - Functional connectivity KW - Cognitive network UR - https://www.sciencedirect.com/science/article/pii/S1525505020305886?via%3Dihub L2 - https://www.sciencedirect.com/science/article/pii/S1525505020305886?via%3Dihub N2 - Objective: We investigated cognitive task-related functional connectivity (FC) in patients with temporal lobe epilepsy (TLE). Using a visual three-stimulus paradigm (VTSP), we studied cognitive large-scale networks and the impact of TLE on connectivity outside the temporal lobe. Methods: High-density electroencephalography (EEG) was recorded during the paradigm from nineteen patients with epilepsy with hippocampal sclerosis (HS) and ten healthy controls (HCs). Scalp data were reconstructed into the source space, and FC was computed. Correlating with the neuropsychological data, possible compensatory mechanisms were investigated. Results: Significant changes were found in the EC of regions outside the epileptogenic network, particularly in the attentional network. These changes were more widespread in left TLE (LTLE). There were no significant differences in task performance (accuracy, time response) in comparison with HCs, implying that there must be some mechanism reducing the impact of connectivity changes on brain functions. When correlated with neuropsychological data, we found stronger compensatory mechanisms in right TLE (RILE). Significance: Our findings confirm the hypothesis that DIE is the more pervasive form of the disease. Even though the network alterations in TLE are severe, some mechanisms reduce the impact of epilepsy on cognitive functions; these mechanisms are more potent in RILE. We also suggest that there are maladaptive mechanisms in LTLE. (C) 2020 Elsevier Inc. All rights reserved. ER -
STRÝČEK, Ondřej, Martin LAMOŠ, P. KLIMES and Ivan REKTOR. Cognitive task-related functional connectivity alterations in temporal lobe epilepsy. \textit{EPILEPSY \&{}amp; BEHAVIOR}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020, vol.~112, NOV, p.~107409-107415. ISSN~1525-5050. Available from: https://dx.doi.org/10.1016/j.yebeh.2020.107409.
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