TGF-beta regulates Sca-1 expression and plasticity of
pre-neoplastic mammary epithelial stem cells

J 2020

TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells

REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO et. al.

Basic information

Original name

TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells

Authors

REMŠÍK, Ján (703 Slovakia, belonging to the institution), Markéta PÍCKOVÁ (203 Czech Republic, belonging to the institution), Ondřej VACEK (203 Czech Republic, belonging to the institution), Radek FEDR, Lucia BINO, Aleš HAMPL (203 Czech Republic, belonging to the institution) and Karel SOUČEK (203 Czech Republic, guarantor, belonging to the institution)

Edition

Scientific reports, London, Nature Publishing Group, 2020, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.379

RIV identification code

RIV/00216224:14310/20:00117612

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1038/s41598-020-67827-4

UT WoS

000548564900110

Keywords in English

Breast cancer; Cancer stem cells

Abstract

V originále

The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.

Links

EF16_025/0007381, research and development project

Name: Preklinická progrese nových organických sloučenin s cílenou biologickou aktivitou

Citovat

REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO, Aleš HAMPL and Karel SOUČEK. TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells. Scientific reports. London: Nature Publishing Group, 2020, vol. 10, No 1, p. 1-12. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-67827-4.

@article{1721656,
   author = {Remšík, Ján and Pícková, Markéta and Vacek, Ondřej and Fedr, Radek and Bino, Lucia and Hampl, Aleš and Souček, Karel},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-020-67827-4},
   keywords = {Breast cancer; Cancer stem cells},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific reports},
   title = {TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells},
   url = {https://doi.org/10.1038/s41598-020-67827-4},
   volume = {10},
   year = {2020}
}

TY  - JOUR
ID  - 1721656
AU  - Remšík, Ján - Pícková, Markéta - Vacek, Ondřej - Fedr, Radek - Bino, Lucia - Hampl, Aleš - Souček, Karel
PY  - 2020
TI  - TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells
JF  - Scientific reports
VL  - 10
IS  - 1
SP  - 1-12
EP  - 1-12
PB  - Nature Publishing Group
SN  - 20452322
KW  - Breast cancer
KW  - Cancer stem cells
UR  - https://doi.org/10.1038/s41598-020-67827-4
L2  - https://doi.org/10.1038/s41598-020-67827-4
N2  - The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection between cell surface markers and distinct cell phenotypes. We mechanistically dissected the TGF-beta family-driven regulation of Sca-1, one of the most commonly used adult stem cell markers. We further provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumor-initiating cells in pre-neoplastic cells.
ER  -

REMŠÍK, Ján, Markéta PÍCKOVÁ, Ondřej VACEK, Radek FEDR, Lucia BINO, Aleš HAMPL and Karel SOUČEK. TGF-beta regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells. \textit{Scientific reports}. London: Nature Publishing Group, 2020, vol.~10, No~1, p.~1-12. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-020-67827-4.

Detailed Information on Publication Record