| MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Y.S. NIKOLOVA. Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort. CEREBRAL CORTEX. CARY: OXFORD UNIV PRESS INC, 2020, vol. 30, No 7, p. 3991-3999. ISSN 1047-3211. Available from: https://dx.doi.org/10.1093/cercor/bhaa014. |
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@article{1721738,
author = {Marečková, Klára and Mareček, Radek and Andrýsková, Lenka and Brázdil, Milan and Nikolova, Y.S.},
article_location = {CARY},
article_number = {7},
doi = {http://dx.doi.org/10.1093/cercor/bhaa014},
keywords = {anxiety; brain age gap; dysregulated mood; magnetic resonance imaging; maternal depression during pregnancy},
language = {eng},
issn = {1047-3211},
journal = {CEREBRAL CORTEX},
title = {Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort},
url = {https://academic.oup.com/cercor/article-abstract/30/7/3991/5763075?redirectedFrom=fulltext},
volume = {30},
year = {2020}
}
TY - JOUR
ID - 1721738
AU - Marečková, Klára - Mareček, Radek - Andrýsková, Lenka - Brázdil, Milan - Nikolova, Y.S.
PY - 2020
TI - Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort
JF - CEREBRAL CORTEX
VL - 30
IS - 7
SP - 3991-3999
EP - 3991-3999
PB - OXFORD UNIV PRESS INC
SN - 10473211
KW - anxiety
KW - brain age gap
KW - dysregulated mood
KW - magnetic resonance imaging
KW - maternal depression during pregnancy
UR - https://academic.oup.com/cercor/article-abstract/30/7/3991/5763075?redirectedFrom=fulltext
L2 - https://academic.oup.com/cercor/article-abstract/30/7/3991/5763075?redirectedFrom=fulltext
N2 - Maternal depression during pregnancy is associated with elevated risk of anxiety and depression in offspring, but the mechanisms are incompletely understood. Here we conducted a neuroimaging follow-up of a prenatal birth cohort from the European Longitudinal Study of Pregnancy and Childhood (n= 131; 53% women, age 23-24) to test whether deviations from age-normative structural brain development in young adulthood may partially underlie this link. Structural brain age was calculated based on previously published neuroanatomical age prediction models using cortical thickness maps from healthy controls aged 6-89. Brain age gap was computed as the difference between chronological and structural brain age. Participants also completed self-report measures of anxiety and mood dysregulation. Further, mothers of a subset of participants (n= 103, 54% women) answered a self-report questionnaire in 1990-1992 about depressive symptoms during pregnancy. Higher exposure to maternal depressive symptoms in utero showed a linear relationship with elevated brain age gap, which showed a quadratic relationship with anxiety and mood dysregulation in the young adult offspring. Our findings suggest that exposure to maternal depressive symptoms in utero may be associated with accelerated brain maturation and that deviations from age-normative structural brain development in either direction predict more anxiety and dysregulated mood in young adulthood.
ER -
MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Y.S. NIKOLOVA. Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort. \textit{CEREBRAL CORTEX}. CARY: OXFORD UNIV PRESS INC, 2020, vol.~30, No~7, p.~3991-3999. ISSN~1047-3211. Available from: https://dx.doi.org/10.1093/cercor/bhaa014.
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