Maternal Depressive Symptoms During Pregnancy and Brain Age in
Young Adult Offspring: Findings from a Prenatal Birth Cohort

J 2020

Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort

MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL, Y.S. NIKOLOVA et. al.

Basic information

Original name

Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort

Authors

MAREČKOVÁ, Klára (203 Czech Republic, guarantor, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Lenka ANDRÝSKOVÁ (203 Czech Republic, belonging to the institution), Milan BRÁZDIL (203 Czech Republic, belonging to the institution) and Y.S. NIKOLOVA

Edition

CEREBRAL CORTEX, CARY, OXFORD UNIV PRESS INC, 2020, 1047-3211

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 5.357

RIV identification code

RIV/00216224:14740/20:00117619

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1093/cercor/bhaa014

UT WoS

000574296400010

Keywords in English

anxiety; brain age gap; dysregulated mood; magnetic resonance imaging; maternal depression during pregnancy

Abstract

V originále

Maternal depression during pregnancy is associated with elevated risk of anxiety and depression in offspring, but the mechanisms are incompletely understood. Here we conducted a neuroimaging follow-up of a prenatal birth cohort from the European Longitudinal Study of Pregnancy and Childhood (n= 131; 53% women, age 23-24) to test whether deviations from age-normative structural brain development in young adulthood may partially underlie this link. Structural brain age was calculated based on previously published neuroanatomical age prediction models using cortical thickness maps from healthy controls aged 6-89. Brain age gap was computed as the difference between chronological and structural brain age. Participants also completed self-report measures of anxiety and mood dysregulation. Further, mothers of a subset of participants (n= 103, 54% women) answered a self-report questionnaire in 1990-1992 about depressive symptoms during pregnancy. Higher exposure to maternal depressive symptoms in utero showed a linear relationship with elevated brain age gap, which showed a quadratic relationship with anxiety and mood dysregulation in the young adult offspring. Our findings suggest that exposure to maternal depressive symptoms in utero may be associated with accelerated brain maturation and that deviations from age-normative structural brain development in either direction predict more anxiety and dysregulated mood in young adulthood.

Links

EF16_013/0001775, research and development project

Name: Modernizace a podpora výzkumných aktivit národní infrastruktury pro biologické a medicínské zobrazování Czech-BioImaging

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

90062, large research infrastructures

Name: Czech-BioImaging

Citovat

MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Y.S. NIKOLOVA. Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort. CEREBRAL CORTEX. CARY: OXFORD UNIV PRESS INC, 2020, vol. 30, No 7, p. 3991-3999. ISSN 1047-3211. Available from: https://dx.doi.org/10.1093/cercor/bhaa014.

@article{1721738,
   author = {Marečková, Klára and Mareček, Radek and Andrýsková, Lenka and Brázdil, Milan and Nikolova, Y.S.},
   article_location = {CARY},
   article_number = {7},
   doi = {http://dx.doi.org/10.1093/cercor/bhaa014},
   keywords = {anxiety; brain age gap; dysregulated mood; magnetic resonance imaging; maternal depression during pregnancy},
   language = {eng},
   issn = {1047-3211},
   journal = {CEREBRAL CORTEX},
   title = {Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort},
   url = {https://academic.oup.com/cercor/article-abstract/30/7/3991/5763075?redirectedFrom=fulltext},
   volume = {30},
   year = {2020}
}

TY  - JOUR
ID  - 1721738
AU  - Marečková, Klára - Mareček, Radek - Andrýsková, Lenka - Brázdil, Milan - Nikolova, Y.S.
PY  - 2020
TI  - Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort
JF  - CEREBRAL CORTEX
VL  - 30
IS  - 7
SP  - 3991-3999
EP  - 3991-3999
PB  - OXFORD UNIV PRESS INC
SN  - 10473211
KW  - anxiety
KW  - brain age gap
KW  - dysregulated mood
KW  - magnetic resonance imaging
KW  - maternal depression during pregnancy
UR  - https://academic.oup.com/cercor/article-abstract/30/7/3991/5763075?redirectedFrom=fulltext
L2  - https://academic.oup.com/cercor/article-abstract/30/7/3991/5763075?redirectedFrom=fulltext
N2  - Maternal depression during pregnancy is associated with elevated risk of anxiety and depression in offspring, but the mechanisms are incompletely understood. Here we conducted a neuroimaging follow-up of a prenatal birth cohort from the European Longitudinal Study of Pregnancy and Childhood (n= 131; 53% women, age 23-24) to test whether deviations from age-normative structural brain development in young adulthood may partially underlie this link. Structural brain age was calculated based on previously published neuroanatomical age prediction models using cortical thickness maps from healthy controls aged 6-89. Brain age gap was computed as the difference between chronological and structural brain age. Participants also completed self-report measures of anxiety and mood dysregulation. Further, mothers of a subset of participants (n= 103, 54% women) answered a self-report questionnaire in 1990-1992 about depressive symptoms during pregnancy. Higher exposure to maternal depressive symptoms in utero showed a linear relationship with elevated brain age gap, which showed a quadratic relationship with anxiety and mood dysregulation in the young adult offspring. Our findings suggest that exposure to maternal depressive symptoms in utero may be associated with accelerated brain maturation and that deviations from age-normative structural brain development in either direction predict more anxiety and dysregulated mood in young adulthood.
ER  -

MAREČKOVÁ, Klára, Radek MAREČEK, Lenka ANDRÝSKOVÁ, Milan BRÁZDIL and Y.S. NIKOLOVA. Maternal Depressive Symptoms During Pregnancy and Brain Age in Young Adult Offspring: Findings from a Prenatal Birth Cohort. \textit{CEREBRAL CORTEX}. CARY: OXFORD UNIV PRESS INC, 2020, vol.~30, No~7, p.~3991-3999. ISSN~1047-3211. Available from: https://dx.doi.org/10.1093/cercor/bhaa014.

Detailed Information on Publication Record