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@article{1721756,
author = {Vondráček, Jan and Pěnčíková, Kateřina and Ciganek, Miroslav and Pivnička, Jakub and Karasová, Martina and Hýžďalová, Martina and Strapáčová, Simona and Pálková, Lenka and Neča, Jiří and Matthews, Jason and Vojtíšek Lom, Michal and Topinka, Jan and Milcová, Alena and Machala, Miroslav},
article_location = {Oxford},
article_number = {November 2020},
doi = {http://dx.doi.org/10.1016/j.envpol.2020.115125},
keywords = {AhR; Carcinogenic PAHs; Anti-estrogenicity; Lung cell toxicity; Genotoxicity},
language = {eng},
issn = {0269-7491},
journal = {Environmental Pollution},
title = {Environmental six-ring polycyclic aromatic hydrocarbons are potent inducers of the AhR-dependent signaling in human cells},
url = {https://doi.org/10.1016/j.envpol.2020.115125},
volume = {266},
year = {2020}
}
TY - JOUR
ID - 1721756
AU - Vondráček, Jan - Pěnčíková, Kateřina - Ciganek, Miroslav - Pivnička, Jakub - Karasová, Martina - Hýžďalová, Martina - Strapáčová, Simona - Pálková, Lenka - Neča, Jiří - Matthews, Jason - Vojtíšek Lom, Michal - Topinka, Jan - Milcová, Alena - Machala, Miroslav
PY - 2020
TI - Environmental six-ring polycyclic aromatic hydrocarbons are potent inducers of the AhR-dependent signaling in human cells
JF - Environmental Pollution
VL - 266
IS - November 2020
SP - 1-13
EP - 1-13
PB - Elsevier
SN - 02697491
KW - AhR
KW - Carcinogenic PAHs
KW - Anti-estrogenicity
KW - Lung cell toxicity
KW - Genotoxicity
UR - https://doi.org/10.1016/j.envpol.2020.115125
L2 - https://doi.org/10.1016/j.envpol.2020.115125
N2 - The toxicities of many environmental polycyclic aromatic hydrocarbons (PAHs), in particular those of high-molecular-weight PAHs (with MW higher than 300), remain poorly characterized. The objective of this study was to evaluate the ability of selected environmentally relevant PAHs with MW 302 (MW302 PAHs) to activate the aryl hydrocarbon receptor (AhR), since this represents a major toxic mode of action of PAHs. A large number of the evaluated compounds exhibited strong AhR-mediated activities, in particular in human models. The studied MW302 PAHs also significantly contributed to the overall calculated AhR activities of complex environmental mixtures, including both defined standard reference materials and collected diesel exhaust particles. The high AhR-mediated activities of representative MW302 PAHs, e.g. naphtho[1,2-k]fluoranthene, corresponded with the modulation of expression of relevant AhR target genes in a human lung cell model, or with the AhR-dependent suppression of cell cycle progression/proliferation in estrogen-sensitive cells. This was in a marked contrast with the limited genotoxicity of the same compound(s). Given the substantial levels of the AhR-activating MW302 PAHs in combustion particles, it seems important to continue to investigate the toxic modes of action of this large group of PAHs associated with airborne particulate matter.
ER -
VONDRÁČEK, Jan, Kateřina PĚNČÍKOVÁ, Miroslav CIGANEK, Jakub PIVNIČKA, Martina KARASOVÁ, Martina HÝŽĎALOVÁ, Simona STRAPÁČOVÁ, Lenka PÁLKOVÁ, Jiří NEČA, Jason MATTHEWS, Michal VOJTÍŠEK LOM, Jan TOPINKA, Alena MILCOVÁ and Miroslav MACHALA. Environmental six-ring polycyclic aromatic hydrocarbons are potent inducers of the AhR-dependent signaling in human cells. \textit{Environmental Pollution}. Oxford: Elsevier, 2020, vol.~266, November 2020, p.~1-13. ISSN~0269-7491. Available from: https://dx.doi.org/10.1016/j.envpol.2020.115125.
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