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@inproceedings{1722203, author = {Dobrovodský, Daniel and Daňhel, Aleš and Malíková, Jana and Fojta, Miroslav}, address = {PRAGUE}, booktitle = {PROCEEDINGS OF THE 15TH INTERNATIONAL STUDENTS CONFERENCE MODERN ANALYTICAL CHEMISTRY}, editor = {Nesmerak, K}, keywords = {cyclic voltammetry; G-quadruplex; hanging mercury drop electrode; porphyrins}, howpublished = {elektronická verze "online"}, language = {eng}, location = {PRAGUE}, isbn = {978-80-7444-068-7}, pages = {215-219}, publisher = {CHARLES UNIV, FAC SCIENCE}, title = {Electrochemical detection of G-quadruplex by interaction with porphyrin ligand}, year = {2019} }
TY - JOUR ID - 1722203 AU - Dobrovodský, Daniel - Daňhel, Aleš - Malíková, Jana - Fojta, Miroslav PY - 2019 TI - Electrochemical detection of G-quadruplex by interaction with porphyrin ligand PB - CHARLES UNIV, FAC SCIENCE CY - PRAGUE SN - 9788074440687 KW - cyclic voltammetry KW - G-quadruplex KW - hanging mercury drop electrode KW - porphyrins N2 - Porphyrins are well-known binders of DNA and can also specifically target guanine quadruplexes (G4). Interaction of a selected porphyrin (Cu-TMPyPP) with oligonucleotide sequences either forming or not forming G4 was studied using cyclic voltammetry at hanging mercury drop electrode. The interaction is shown to be detectable by cyclic voltammetry as potential shift of a characteristic peak of Cu-TMPyPP which is observed for G4, single stranded as well as double stranded DNA. Nevertheless, further changes of this peak resulting from application of cyclic potential scans to the studied DNA before interaction with Cu-TMPyPP can be used to clearly distinguish G4 DNA, which can be applied as analytical tool for its detection. ER -
DOBROVODSKÝ, Daniel, Aleš DAŇHEL, Jana MALÍKOVÁ and Miroslav FOJTA. Electrochemical detection of G-quadruplex by interaction with porphyrin ligand. Online. In Nesmerak, K. \textit{PROCEEDINGS OF THE 15TH INTERNATIONAL STUDENTS CONFERENCE MODERN ANALYTICAL CHEMISTRY}. PRAGUE: CHARLES UNIV, FAC SCIENCE, 2019, p.~215-219. ISBN~978-80-7444-068-7.
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