Detailed Information on Publication Record
2020
Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge
SVAČINOVÁ, Jana, Jana HRUŠKOVÁ, Juraj JAKUBÍK, Ksenia BUDINSKAYA, Simona HIDEGOVÁ et. al.Basic information
Original name
Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge
Authors
SVAČINOVÁ, Jana (203 Czech Republic, guarantor, belonging to the institution), Jana HRUŠKOVÁ (203 Czech Republic, belonging to the institution), Juraj JAKUBÍK (703 Slovakia, belonging to the institution), Ksenia BUDINSKAYA (643 Russian Federation, belonging to the institution), Simona HIDEGOVÁ (203 Czech Republic), Martin FABŠÍK (703 Slovakia, belonging to the institution), Helena SIEGLOVÁ (203 Czech Republic, belonging to the institution), Zuzana KAŠČÁKOVÁ (703 Slovakia, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution) and Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution)
Edition
Physiological Research, Prague, ACAD SCIENCES CZECH REPUBLIC, 2020, 0862-8408
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Denmark
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 1.881
RIV identification code
RIV/00216224:14110/20:00117671
Organization unit
Faculty of Medicine
UT WoS
000610191500007
Keywords in English
Pulse wave velocity; Variability; Diabetes mellitus; Arterial stiffness; Orthostasis
Tags
International impact, Reviewed
Změněno: 26/2/2021 10:25, Mgr. Tereza Miškechová
Abstract
V originále
Diabetes mellitus 2 (DM2) is the seventh cause of death worldwide. One of the reasons is late diagnosis of vascular damage. Pulse wave velocity (PWV) has become an independent marker of arterial stiffness and cardiovascular risk. Moreover, the previous studies have shown the importance of beat-to-beat PWV measurement due to its variability among the heart cycle. However, variability of PWV (PWVv) of the whole body hasn't been examined yet. We have studied a group of DM II and heathy volunteers, to investigate the beat-to-beat mean PWV (PWVm) and PWVv in the different body positions. PWV of left lower and upper extremities were measured in DM2 (7 m/8 f, age 68±10 years, BP 158/90±19/9 mm Hg) and healthy controls (5 m/6 f, age 23±2 years, BP 117/76±9/5 mm Hg). Volunteers were lying in the resting position and of head-up-tilt in 45° (HUT) for 6 min. PWVv was evaluated as a mean power spectrum in the frequency bands LF and HF (0.04-0.15 Hz, 0.15-0.5 Hz). Resting PWVm of upper extremity was higher in DM2. HUT increased lower extremity PWVm only in DM2. Extremities PWVm ratio was significantly lower in DM2 during HUT compared to controls. LF and HF PWVv had the same response to HUT. Resting PWVv was higher in DM2. Lower extremity PWVv increased during HUT in both groups. PWVm and PWVv in DM2 differed between extremities and were significantly influenced by postural changes due to hydrostatic pressure. Increased resting PWVm and PWVv in DM2 is a marker of increased arterial stiffness.
Links
MUNI/A/1307/2019, interní kód MU |
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MUNI/A/1403/2019, interní kód MU |
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ROZV/28/LF18/2020, interní kód MU |
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