J 2020

Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge

SVAČINOVÁ, Jana, Jana HRUŠKOVÁ, Juraj JAKUBÍK, Ksenia BUDINSKAYA, Simona HIDEGOVÁ et. al.

Basic information

Original name

Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge

Authors

SVAČINOVÁ, Jana (203 Czech Republic, guarantor, belonging to the institution), Jana HRUŠKOVÁ (203 Czech Republic, belonging to the institution), Juraj JAKUBÍK (703 Slovakia, belonging to the institution), Ksenia BUDINSKAYA (643 Russian Federation, belonging to the institution), Simona HIDEGOVÁ (203 Czech Republic), Martin FABŠÍK (703 Slovakia, belonging to the institution), Helena SIEGLOVÁ (203 Czech Republic, belonging to the institution), Zuzana KAŠČÁKOVÁ (703 Slovakia, belonging to the institution), Jan NOVÁK (203 Czech Republic, belonging to the institution) and Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution)

Edition

Physiological Research, Prague, ACAD SCIENCES CZECH REPUBLIC, 2020, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Denmark

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.881

RIV identification code

RIV/00216224:14110/20:00117671

Organization unit

Faculty of Medicine

UT WoS

000610191500007

Keywords in English

Pulse wave velocity; Variability; Diabetes mellitus; Arterial stiffness; Orthostasis

Tags

International impact, Reviewed
Změněno: 26/2/2021 10:25, Mgr. Tereza Miškechová

Abstract

V originále

Diabetes mellitus 2 (DM2) is the seventh cause of death worldwide. One of the reasons is late diagnosis of vascular damage. Pulse wave velocity (PWV) has become an independent marker of arterial stiffness and cardiovascular risk. Moreover, the previous studies have shown the importance of beat-to-beat PWV measurement due to its variability among the heart cycle. However, variability of PWV (PWVv) of the whole body hasn't been examined yet. We have studied a group of DM II and heathy volunteers, to investigate the beat-to-beat mean PWV (PWVm) and PWVv in the different body positions. PWV of left lower and upper extremities were measured in DM2 (7 m/8 f, age 68±10 years, BP 158/90±19/9 mm Hg) and healthy controls (5 m/6 f, age 23±2 years, BP 117/76±9/5 mm Hg). Volunteers were lying in the resting position and of head-up-tilt in 45° (HUT) for 6 min. PWVv was evaluated as a mean power spectrum in the frequency bands LF and HF (0.04-0.15 Hz, 0.15-0.5 Hz). Resting PWVm of upper extremity was higher in DM2. HUT increased lower extremity PWVm only in DM2. Extremities PWVm ratio was significantly lower in DM2 during HUT compared to controls. LF and HF PWVv had the same response to HUT. Resting PWVv was higher in DM2. Lower extremity PWVv increased during HUT in both groups. PWVm and PWVv in DM2 differed between extremities and were significantly influenced by postural changes due to hydrostatic pressure. Increased resting PWVm and PWVv in DM2 is a marker of increased arterial stiffness.

Links

MUNI/A/1307/2019, interní kód MU
Name: Kardiovaskulární systém od A do Z (Acronym: KAVASAZ)
Investor: Masaryk University, Category A
MUNI/A/1403/2019, interní kód MU
Name: Diferenciální diagnostika a odhad prognózy interních nemocí 4 (Acronym: DIDIPRON 4)
Investor: Masaryk University, Category A
ROZV/28/LF18/2020, interní kód MU
Name: Analýza odpovědi parametrů kardiovaskulárního systému na ortostatickou zátěž
Investor: Ministry of Education, Youth and Sports of the CR, Internal development projects