| SVAČINOVÁ, Jana, Jana HRUŠKOVÁ, Juraj JAKUBÍK, Ksenia BUDINSKAYA, Simona HIDEGOVÁ, Martin FABŠÍK, Helena SIEGLOVÁ, Zuzana KAŠČÁKOVÁ, Jan NOVÁK and Zuzana NOVÁKOVÁ. Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge. Physiological Research. Prague: ACAD SCIENCES CZECH REPUBLIC, 2020, vol. 69, Supplement 3, p. "S433"-"S441", 9 pp. ISSN 0862-8408. Available from: https://dx.doi.org/10.33549/physiolres.934594. |
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@article{1724896,
author = {Svačinová, Jana and Hrušková, Jana and Jakubík, Juraj and Budinskaya, Ksenia and Hidegová, Simona and Fabšík, Martin and Sieglová, Helena and Kaščáková, Zuzana and Novák, Jan and Nováková, Zuzana},
article_location = {Prague},
article_number = {Supplement 3},
doi = {http://dx.doi.org/10.33549/physiolres.934594},
keywords = {Pulse wave velocity; Variability; Diabetes mellitus; Arterial stiffness; Orthostasis},
language = {eng},
issn = {0862-8408},
journal = {Physiological Research},
title = {Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge},
url = {https://www.biomed.cas.cz/physiolres/pdf/2020/69_S433.pdf},
volume = {69},
year = {2020}
}
TY - JOUR
ID - 1724896
AU - Svačinová, Jana - Hrušková, Jana - Jakubík, Juraj - Budinskaya, Ksenia - Hidegová, Simona - Fabšík, Martin - Sieglová, Helena - Kaščáková, Zuzana - Novák, Jan - Nováková, Zuzana
PY - 2020
TI - Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge
JF - Physiological Research
VL - 69
IS - Supplement 3
SP - "S433"-"S441"
EP - "S433"-"S441"
PB - ACAD SCIENCES CZECH REPUBLIC
SN - 08628408
KW - Pulse wave velocity
KW - Variability
KW - Diabetes mellitus
KW - Arterial stiffness
KW - Orthostasis
UR - https://www.biomed.cas.cz/physiolres/pdf/2020/69_S433.pdf
L2 - https://www.biomed.cas.cz/physiolres/pdf/2020/69_S433.pdf
N2 - Diabetes mellitus 2 (DM2) is the seventh cause of death worldwide. One of the reasons is late diagnosis of vascular damage. Pulse wave velocity (PWV) has become an independent marker of arterial stiffness and cardiovascular risk. Moreover, the previous studies have shown the importance of beat-to-beat PWV measurement due to its variability among the heart cycle. However, variability of PWV (PWVv) of the whole body hasn't been examined yet. We have studied a group of DM II and heathy volunteers, to investigate the beat-to-beat mean PWV (PWVm) and PWVv in the different body positions. PWV of left lower and upper extremities were measured in DM2 (7 m/8 f, age 68±10 years, BP 158/90±19/9 mm Hg) and healthy controls (5 m/6 f, age 23±2 years, BP 117/76±9/5 mm Hg). Volunteers were lying in the resting position and of head-up-tilt in 45° (HUT) for 6 min. PWVv was evaluated as a mean power spectrum in the frequency bands LF and HF (0.04-0.15 Hz, 0.15-0.5 Hz). Resting PWVm of upper extremity was higher in DM2. HUT increased lower extremity PWVm only in DM2. Extremities PWVm ratio was significantly lower in DM2 during HUT compared to controls. LF and HF PWVv had the same response to HUT. Resting PWVv was higher in DM2. Lower extremity PWVv increased during HUT in both groups. PWVm and PWVv in DM2 differed between extremities and were significantly influenced by postural changes due to hydrostatic pressure. Increased resting PWVm and PWVv in DM2 is a marker of increased arterial stiffness.
ER -
SVAČINOVÁ, Jana, Jana HRUŠKOVÁ, Juraj JAKUBÍK, Ksenia BUDINSKAYA, Simona HIDEGOVÁ, Martin FABŠÍK, Helena SIEGLOVÁ, Zuzana KAŠČÁKOVÁ, Jan NOVÁK and Zuzana NOVÁKOVÁ. Variability of Peripheral Pulse Wave Velocity in Patients With Diabetes Mellitus Type 2 During Orthostatic Challenge. \textit{Physiological Research}. Prague: ACAD SCIENCES CZECH REPUBLIC, 2020, vol.~69, Supplement 3, p.~''S433''-''S441'', 9 pp. ISSN~0862-8408. Available from: https://dx.doi.org/10.33549/physiolres.934594.
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