JURČEK, Ondřej, N. NONAPPA, Elina KALENIUS, Pia Yasmine JURČEK, Juha M. LINNANTO, Rakesh PUTTREDDY, Hennie VALKENIER, Nikolay HOUBENOV, Michal BABIAK, Miroslav PETEREK, Anthony P. DAVIS, Radek MAREK and Kari RISSANEN. Hexagonal Microparticles from Hierarchical Self-Organization of Chiral Trigonal Pd3L6 Macrotetracycles. Cell Reports Physical Science. Cell Press, vol. 2, No 1, p. 100303-100321. ISSN 2666-3864. doi:10.1016/j.xcrp.2020.100303. 2021.
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Basic information
Original name Hexagonal Microparticles from Hierarchical Self-Organization of Chiral Trigonal Pd3L6 Macrotetracycles
Authors JURČEK, Ondřej (203 Czech Republic, guarantor, belonging to the institution), N. NONAPPA (356 India), Elina KALENIUS (246 Finland), Pia Yasmine JURČEK (246 Finland, belonging to the institution), Juha M. LINNANTO (246 Finland), Rakesh PUTTREDDY (356 India), Hennie VALKENIER (56 Belgium), Nikolay HOUBENOV (246 Finland), Michal BABIAK (703 Slovakia, belonging to the institution), Miroslav PETEREK (203 Czech Republic, belonging to the institution), Anthony P. DAVIS (826 United Kingdom of Great Britain and Northern Ireland), Radek MAREK (203 Czech Republic, belonging to the institution) and Kari RISSANEN (246 Finland).
Edition Cell Reports Physical Science, Cell Press, 2021, 2666-3864.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10400 1.4 Chemical sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 7.832
RIV identification code RIV/00216224:14740/21:00118816
Organization unit Central European Institute of Technology
Doi http://dx.doi.org/10.1016/j.xcrp.2020.100303
UT WoS 000658759800020
Keywords in English Supramolecular Chemistry; Bile Acid; Palladium; Heterotopic Ligand; Transmetalation; Self-Assembly; Chirality; Surfactant; Self-Organization; Particle
Tags CF CRYO, CF NMR, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 25/2/2022 22:11.
Abstract
Construction of structurally complex architectures using inherently chiral, asymmetric, or multi-heterotopic ligands is a major challenge in metallosupramolecular chemistry. Moreover, the hierarchical self-organization of such complexes is unique. Here, we introduce a water-soluble, facially amphiphilic, amphoteric, chiral, asymmetric, and hetero-tritopic ligand derived from natural bile acid, ursodeoxycholic acid. We show that via the supramolecular transmetalation reaction, using nitrates of Cu(II) or Fe(III), and subsequently Pd(II), a superchiral Pd3L6 complex can be obtained. Even though several possible constitutional isomers of Pd3L6 could be formed, because of the ligand asymmetry and relative flexibility of carbamate-pyridyl moieties attached to the steroid scaffold, only a single product with C3 rotational symmetry was obtained. Finally, we demonstrate that these amphiphilic complexes can self-organize into hexagonal microparticles in aqueous media. This finding may lead to the development of novel self-assembled metal-organic functional materials made of natural, abundant, and relatively inexpensive steroidal compounds.
Links
EF18_070/0009846, research and development projectName: MSCAfellow2@MUNI
GA18-05421S, research and development projectName: Rozvoj paramagnetické NMR spektroskopie pro supramolekulární systémy (Acronym: SUPRAMAG)
Investor: Czech Science Foundation
LM2018127, research and development projectName: Česká infrastruktura pro integrativní strukturní biologii (Acronym: CIISB)
Investor: Ministry of Education, Youth and Sports of the CR
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR
5SA15055, interní kód MUName: Metal-Organic Materials for Pharmaceutical Applications (Acronym: MOPHARM)
Investor: South-Moravian Region
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