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@article{1725776,
author = {Andršová, Irena and Hnatkova, Katerina and Šišáková, Martina and Toman, Ondřej and Smetana, Peter and Huster, Katharina M. and Barthel, Petra and Novotný, Tomáš and Schmidt, Georg and Malík, Marek},
article_location = {Basel},
article_number = {12},
doi = {http://dx.doi.org/10.3390/diagnostics10121096},
keywords = {QT variability; RR variability; QT variability index; underlying heart rate; sequential analysis of regression variance},
language = {eng},
issn = {2075-4418},
journal = {Diagnostics},
title = {Heart Rate Influence on the QT Variability Risk Factors},
url = {https://www.mdpi.com/2075-4418/10/12/1096},
volume = {10},
year = {2020}
}
TY - JOUR
ID - 1725776
AU - Andršová, Irena - Hnatkova, Katerina - Šišáková, Martina - Toman, Ondřej - Smetana, Peter - Huster, Katharina M. - Barthel, Petra - Novotný, Tomáš - Schmidt, Georg - Malík, Marek
PY - 2020
TI - Heart Rate Influence on the QT Variability Risk Factors
JF - Diagnostics
VL - 10
IS - 12
SP - 1-16
EP - 1-16
PB - MDPI
SN - 20754418
KW - QT variability
KW - RR variability
KW - QT variability index
KW - underlying heart rate
KW - sequential analysis of regression variance
UR - https://www.mdpi.com/2075-4418/10/12/1096
L2 - https://www.mdpi.com/2075-4418/10/12/1096
N2 - QT interval variability, mostly expressed by QT variability index (QTVi), has repeatedly been used in risk diagnostics. Physiologic correlates of QT variability expressions have been little researched especially when measured in short 10-second electrocardiograms (ECGs). This study investigated different QT variability indices, including QTVi and the standard deviation of QT interval durations (SDQT) in 657,287 10-second ECGs recorded in 523 healthy subjects (259 females). The indices were related to the underlying heart rate and to the 10-second standard deviation of RR intervals (SDRR). The analyses showed that both QTVi and SDQT (as well as other QT variability indices) were highly statistically significantly (p < 0.00001) influenced by heart rate and that QTVi showed poor intra-subject reproducibility (coefficient of variance approaching 200%). Furthermore, sequential analysis of regression variance showed that SDQT was more strongly related to the underlying heart rate than to SDRR, and that QTVi was influenced by the underlying heart rate and SDRR more strongly than by SDQT (p < 0.00001 for these comparisons of regression dependency). The study concludes that instead of QTVi, simpler expressions of QT interval variability, such as SDQT, appear preferable for future applications especially if multivariable combination with the underlying heart rate is used.
ER -
ANDRŠOVÁ, Irena, Katerina HNATKOVA, Martina ŠIŠÁKOVÁ, Ondřej TOMAN, Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ, Georg SCHMIDT and Marek MALÍK. Heart Rate Influence on the QT Variability Risk Factors. \textit{Diagnostics}. Basel: MDPI, 2020, vol.~10, No~12, p.~1-16. ISSN~2075-4418. Available from: https://dx.doi.org/10.3390/diagnostics10121096.
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