J 2020

Rapid Eye Movement Sleep Sawtooth Waves Are Associated with Widespread Cortical Activations

FRAUSCHER, Birgit, Nicolas VON ELLENRIEDER, Irena DOLEŽALOVÁ, Sarah BOUHADOUN, Jean GOTMAN et. al.

Basic information

Original name

Rapid Eye Movement Sleep Sawtooth Waves Are Associated with Widespread Cortical Activations

Authors

FRAUSCHER, Birgit (124 Canada), Nicolas VON ELLENRIEDER (124 Canada), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Sarah BOUHADOUN (124 Canada), Jean GOTMAN (124 Canada) and Laure PETER-DEREX (124 Canada, guarantor)

Edition

JOURNAL OF NEUROSCIENCE, WASHINGTON, SOC NEUROSCIENCE, 2020, 0270-6474

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 6.167

RIV identification code

RIV/00216224:14110/20:00117696

Organization unit

Faculty of Medicine

DOI

UT WoS

000590386800008

Keywords in English

gamma; polysomnography; REM; signal analysis; sleep; stereo-EEG

Tags

Tags

International impact, Reviewed
Změněno: 12/1/2021 10:47, Mgr. Tereza Miškechová

Abstract

V originále

Sawtooth waves (STW) are bursts of frontocentral slow oscillations recorded in the scalp electroencephalogram (EEG) during rapid eye movement (REM) sleep. Little is known about their cortical generators and functional significance. Stereo-EEG per-formed for presurgical epilepsy evaluation offers the unique possibility to study neurophysiology in situ in the human brain. We investigated intracranial correlates of scalp-detected STW in 26 patients (14 women) undergoing combined stereo-EEG/ polysomnography. We visually marked STW segments in scalp EEG and selected stereo-EEG channels exhibiting normal activity for intracranial analyses. Channels were grouped in 30 brain regions. The spectral power in each channel and frequency band was computed during STW and non-STW control segments. Ripples (80-250 Hz) were automatically detected during STW and control segments. The spectral power in the different frequency bands and the ripple rates were then compared between STW and control segments in each brain region. An increase in 2-4 Hz power during STW segments was found in all brain regions, except the occipital lobe, with large effect sizes in the parietotemporal junction, the lateral and orbital frontal cortex, the anterior insula, and mesiotemporal structures. A widespread increase in high-frequency activity, including ripples, was observed concomitantly, involving the sensorimotor cortex, associative areas, and limbic structures. This distribution showed a high spatiotemporal heterogeneity. Our results suggest that STW are associated with widely distributed, but locally regulated REM sleep slow oscillations. By driving fast activities, STW may orchestrate synchronized reactivations of multifocal activities, allowing tagging of complex representations necessary for REM sleep-dependent memory consolidation.