OTEVŘEL, Jan, David ŠVESTKA a Pavel BOBÁĽ. Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones. ORGANIC & BIOMOLECULAR CHEMISTRY. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2019, roč. 17, č. 21, s. 5244-5248. ISSN 1477-0520. Dostupné z: https://dx.doi.org/10.1039/c9ob00884e. |
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@article{1726933, author = {Otevřel, Jan and Švestka, David and Bobáľ, Pavel}, article_location = {CAMBRIDGE}, article_number = {21}, doi = {http://dx.doi.org/10.1039/c9ob00884e}, keywords = {CATALYSTS; EFFICIENT; AMINES}, language = {eng}, issn = {1477-0520}, journal = {ORGANIC & BIOMOLECULAR CHEMISTRY}, title = {Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones}, url = {https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB00884E}, volume = {17}, year = {2019} }
TY - JOUR ID - 1726933 AU - Otevřel, Jan - Švestka, David - Bobáľ, Pavel PY - 2019 TI - Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones JF - ORGANIC & BIOMOLECULAR CHEMISTRY VL - 17 IS - 21 SP - 5244-5248 EP - 5244-5248 PB - ROYAL SOC CHEMISTRY SN - 14770520 KW - CATALYSTS KW - EFFICIENT KW - AMINES UR - https://pubs.rsc.org/en/content/articlelanding/2019/OB/C9OB00884E N2 - We have developed a catalytic system based on bianthrylbis (thiourea) for the asymmetric Henry reaction of fluoroketones and nitroalkanes that resulted from the screening of a library containing 31 chiral non-racemic organocatalysts. The corresponding adducts were isolated in up to 6 times shorter reaction time in comparison with the previously published organocatalysts. High levels of stereocontrol have been generally observed, with measured product enantiomeric excesses up to 97% and diastereomeric ratio 3 : 2 (anti/syn). The above-mentioned catalysts have been successfully applied to the total asymmetric synthesis of CF3-tethered (S)-halostachines, which has proved that this method constitutes an easy entry to similar enantiopure compounds. ER -
OTEVŘEL, Jan, David ŠVESTKA a Pavel BOBÁĽ. Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones. \textit{ORGANIC \&{} BIOMOLECULAR CHEMISTRY}. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2019, roč.~17, č.~21, s.~5244-5248. ISSN~1477-0520. Dostupné z: https://dx.doi.org/10.1039/c9ob00884e.
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